Accuracy of intra-operative frozen section analysis of ovarian tumours.

During operative treatment for ovarian tumours assistance is frequently required to make decisions regarding malignancy status and the extent of the ensuing procedure. Intra-operative frozen section analysis may be useful, provided there is adequate acquaintance with the correlation between using frozen sections and permanent histopathological sections for diagnosis at the institution where the operation is being undertaken. This retrospective study aimed to determine this correlation.

The role of procalcitonin in gynaecological surgery.

We evaluated postoperative concentrations of inflammatory indicators, including procalcitonin, after gynaecological operations for benign and malignant tumours in patients with a normal postoperative course and assessed the utility of procalcitonin in differentiating between non-bacterial inflammation and bacteraemic complications in the postoperative period. This prospective study included 99 patients: 47 after a standard gynaecological operation (Piver I) and no postoperative infectious complications (group 1), 35 after a major procedure (Piver II or III) and no postoperative infectious complications (group 2), and five with postoperative sepsis after Piver II or III procedures (group 3). We also studied serum procalcitonin concentrations in a group of 12 patients (group 4) with terminal forms of gynaecological cancer who were hospitalized for palliative treatment but did not undergo surgery.

Quality of life and the effect on social status among Slovenian women after breast cancer treatment.

This study investigated whether the type of surgical procedure used to treat breast cancer (mastectomy versus breast-conserving lumpectomy) had any effect on the quality of life and social status of women. The prospective analysis included 382 women newly diagnosed with non-metastatic breast cancer who had undergone a surgical intervention for breast carcinoma at our institution: 198 patients had undergone mastectomy with axillary lymphadenectomy and 184 patients had undergone breast-conserving lumpectomy with local axillary lympha-denectomy. The post-mastectomy women reported significantly more financial problems, a lowered social status and more physical symptoms compared with the breast-conserving post-lumpectomy patients.

Serum CA 125 levels and lymph node metastasis in patients with endometrial cancer.

The aim of this study was to evaluate the correlation of preoperative serum CA 125 levels and lymph node metastasis in patients with endometrial cancer. Preoperative levels of serum CA 125 were determined in 64 patients with endometrial cancer treated with total abdominal hysterectomy with a lymph node dissection as initial therapy. Lymph node status, determined by histopathology, was correlated with both normal and elevated CA 125 levels, determined preoperatively.

Primary breast cancer of the vulva: a case report and review of the literature.

Since 1872, 40 cases of ectopic mammary gland tissue in the vulva have been reported in the literature. Out of these, 12 had a primary cancer in the ectopic breast tissue. Seven metastases of an orthotopic breast cancer have been found in this location.

User friendly inquiry and computer program for following patients with ovarian malignancy.

The establishing of a correct diagnosis in patients with ovarian malignancy requires the combination of a variety of methods of examination. An inquiry for following of malignoma patients has been compiled, accompanied by an adequate computer program. Beside general information regarding the patient, diagnosis and treatment, the inquiry also includes the case history, data regarding clinical, ultrasonographic and preoperative examinations, surgery, histologic findings and follow-up after termination of treatment.

Cold knife conization and loop excision for cervical intraepithelial neoplasia.

Aims And Background: Our aim was to investigate whether loop excision is an acceptable alternative to traditional cold knife conization of the cervix.

Patients And Methods: 240 with cervical intraepithelial neoplasia (CIN) were randomly assigned to loop excision (n = 120) or cold knife conization (n = 120). Success and complication rates of both methods were analysed.

Pelvic actinomycosis.

Pelvic actinomycosis is a rare chronic infection caused by bacteria of the family Actinomycetaceae. Prolonged use of an intrauterine contraceptive device (IUD) is a well known risk factor. We report six patients with pelvic actinomycosis, all of whom had an IUD inserted for over six years.

Chlamydia trachomatis infection in women with and without cervical intraepithelial neoplasia.

The aim of the study was to compare the frequency of Chlamydia trachomatis infection in patients with cervical intraepithelial neoplasia (CIN) and in women without cervical pathology. In a study group of 423 patients with histologically proven CIN and in 108 controls with normal cervical smear, cytological material for direct immunofluorescence analysis was obtained. Among 423 patients, 24 (5.

The frequency of Chlamydia trachomatis infection in women with intraepithelial neoplasia of the uterine cervix.

Objective: To evaluate the frequency of Chlamydia trachomatis (CT) infection in patients with cervical intraepithelial neoplasia (CIN) referred for conisation.

Methods: 423 patients with histologically proven CIN were included in this study. Before conisation, cytological material for direct immunofluorescence analysis was obtained.

[The thrombocytopenia syndrome caused by heparin].

Heparin represents the basis for drug treatment and prevention of thrombosis. However, heparin itself may produce side effects, among others two types of heparin-induced thrombocytopenia (HIT). The more frequent type 1 occurs in about 10% of patients within the first days of the treatment and disappears spontaneously without sequelae.

Human papillomavirus 16 and 18 infection of the uterine cervix in women with different grades of cervical intraepithelial neoplasia (CIN).

Objective: To evaluate the frequency of human papillomavirus (HPV) 16 and 18 infection in patients with different grades of cervical intraepithelial neoplasia (CIN).

Method: Five-hundred and five patients with CIN, referred for conization, were included in this study. Before conization, cytological material for in situ hybridization was obtained from the uterine cervix to detect the presence of HPV 16 and 18 infection.

C-reactive protein and the treatment of pelvic inflammatory disease.

Objective: The significance of C-reactive protein (CRP) in assessing the treatment of pelvic inflammatory disease (PID) was established and compared with body temperature (BT), erythrocyte sedimentation rate (ESR) and serum leukocyte concentration (L).

Method: In 51 patients with PID, 20 (39%) of them with tubo-ovarial abscess (TOA), measurement of BT and laboratory investigations were carried out on admission and during treatment on days 3-4, 6-8 and 18-21. The changes in these values were compared with the changes in clinical condition.

Malignant acanthosis nigricans and tripe palms in a patient with endometrial adenocarcinoma--a case report and review of literature.

Background: In the world literature, uterine carcinoma associated with paraneoplastic malignant acanthosis nigricans and tripe palms has been mentioned in two review articles. Endometrial adenocarcinoma associated with malignant acanthosis nigricans without tripe palms has been cited in three case reports, and endometrial adenocarcinoma associated with tripe palms without malignant acanthosis nigricans has been cited in one case report. We present the case of a patient with endometrial adenocarcinoma associated with acanthosis nigricans and tripe palms which we have been following for the past 7 years.

Preoperative value of CA 125 as a reflection of tumor grade in epithelial ovarian cancer.

A retrospective study of 60 patients with invasive epithelial ovarian cancer was conducted. The significance of preoperative serum CA 125 level with respect to tumor grade and tumor stage was determined. Tumor grade bears a strong influence on the preoperative CA 125 level; the correlation is high and statistically significant (r = 0.

Low doses of heparin and heparin dihydergot in postoperative thromboprophylaxis in gynaecological patients.

A prospective study of postoperative thromboembolic prophylaxis involving 500 gynaecological patients was performed to compare the effectiveness and safety of low doses of heparin (LDH) and heparin-dihydergot (HDHE). In the LDH group 255 patients (51%) aged 26-84 were included, in the HDHE group there were 245 patients (49%) aged 34-86. Both groups were well matched with respect to risk factors, duration of surgery, type of operation, volume of blood transfused and duration of prophylaxis.

Prevention of postoperative thromboembolism in gynaecological malignancy.

A prospective randomized clinical trial compared the efficacy of low doses of heparin (LDH) and heparin plus dihydroergotamine mesylate (HDHE) in the prevention of thromboembolism in gynaecological patients with malignancy undergoing major surgery. One hundred and fifty-five patients, with a mean age 54.5 years were allocated to receive 5,000 IU unfractionated heparin or 5,000 IU unfractionated heparin +0.

[Reconstruction after radical vulvectomy].

From 1981-85, 29 patients with vulvar cancer were operated on. In 19 patients transplants and the transposition and rotation of local flaps were used. Merely in two patients was there minimal dehiscence and the average period of hospitalization amounted to 29 days.

[Diagnosis of breast cancer in the gynecology department].

Breast examinations were performed in 4199 women by a simultaneous carrying out of clinical investigation, thermography and mammography, and, if needed, also by ultrasonic examination and aspiration cytology. A total of 169 women were referred to treatment and biopsy. Among them, 78 had breast cancer.

[Breast cysts--diagnosis and therapy].

The authors present the results of the diagnosis of 1405 cases of macroscopically evident breast cysts. Only 15% patients were younger than 40 and only 6% older than 55 years. All lesions were cytologically analysed.

[The effect of hormonal therapy on the breast in the climacteric syndrome in women].

The author observed three groups of women during their receiving hormonal therapy for the climacteric syndrome. They underwent clinical investigation, mammography and thermography. The first group (n = 31) received 10 mg estradiolmonobenzoate every 6 weeks, the second group (n = 33) 2.

[The role of clinical examination in the diagnosis of breast cancer].

In Slovenia and Croatia breast cancer is registered as the most frequent kind of cancer in women. In 2951 women clinical findings were compared to those obtained by mammography, thermography, palpation and cytology. The analysis showed a statistically significant difference between them.

[Cancer of the uterus treated at the Maribor Hospital from 1961 to 1978].

From 1961-1978, 218 patients with the carcinoma of the corpus uteri were treated in the hospital of Maribor . They were on average 60 years old. In most of the cases (87%) the disease was classified as stage I.