Relationship between neutron yield rate of tokamak plasmas and spectrometer measured flux for different sight lines.

A parametric relationship between total neutron yield rate and collimated fluxes related to the brightness (B) of plasma chords (λ) is developed for different emissivity distributions of tokamak plasmas. Specifically, the brightness was expressed as a function of chord coordinates of radial position using a simple model for the emissivity profiles of width parameter w. The functional brightness dependence B(λ,w) was calculated to examine the relationship between measured flux and deduced yield rate, and its plasma profile dependence.

Lung cancer mortality trend by birth cohort in men, Tuscany, 1971-2006.

Aims And Background: In Tuscany, lung cancer mortality in men has shown a decreasing geographical trend over the last 3 decades from the most industrialized north-western coastal areas (Massa-Carrara, Viareggio) to the south-eastern areas (Arezzo, Siena), following the path of the development of industrial activities. The aim of the study was to evaluate lung cancer mortality in males by birth cohort in order to verify whether there was also a decreasing birth cohort trend in male lung cancer mortality rates between north-western and south-eastern Tuscan areas.

Methods: Lung cancer deaths that occurred in men resident in Tuscany, 1971-2006, were analyzed by birth cohort, age group and local health authority area.

Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.

Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its consequences. Diverse therapeutic interventions can be developed through identification of reliable biomarkers for this disorder and new pharmacological targets for its treatment.

New developments in the diagnostics for the fusion products on JET in preparation for ITER (invited).

Notwithstanding the advances of the past decades, significant developments are still needed to satisfactorily diagnose “burning plasmas.” D–T plasmas indeed require a series of additional measurements for the optimization and control of the configuration: the 14 MeV neutrons, the isotopic composition of the main plasma, the helium ash, and the redistribution and losses of the alpha particles. Moreover a burning plasma environment is in general much more hostile for diagnostics than purely deuterium plasmas.

Neutron spectrometry of JET discharges with ICRH-acceleration of helium beam ions.

Recent experiments at JET aimed at producing 4He ions in the MeV range through third harmonic ion cyclotron resonance heating (ICRH) acceleration of 4He beams in a 4He dominated plasma. MeV range D was also present through parasitic ICRH absorption on residual D. In this contribution, we analyze TOFOR neutron spectrometer data from these experiments.

Energy resolution of gamma-ray spectroscopy of JET plasmas with a LaBr3 scintillator detector and digital data acquisition.

A new high efficiency, high resolution, fast γ-ray spectrometer was recently installed at the JET tokamak. The spectrometer is based on a LaBr3(Ce) scintillator coupled to a photomultiplier tube. A digital data acquisition system is used to allow spectrometry with event rates in excess of 1 MHz expected in future JET DT plasmas.

The 12C(3He,pγ)14N reaction cross section for γ-ray spectroscopy simulation of fusion plasmas.

High resolution γ-ray spectroscopy measurements were performed in JET (3He)D plasmas with high energy ion populations driven by radio-frequency (RF) heating. One of the first reactions investigated was 12C(3He,pγ)14N, which was observed at low 3He concentrations. In order to interpret the measurements in this work, cross section data for the 12C(3He,pγ)14N reaction are evaluated.

Development of novel fuel ion ratio diagnostic techniques.

To overcome the challenge of measuring the fuel ion ratio in the core (ρ<0.3) of ITER, a coordinated effort aiming at developing diagnostic techniques has been initiated. The investigated techniques are novel uses or further development of existing methods such as charge exchange recombination spectrometry, neutron spectrometry, and collective Thomson scattering.

A neutron resonance capture analysis experimental station at the ISIS spallation source.

Neutron resonance capture analysis (NRCA) is a nuclear technique that is used to determine the elemental composition of materials and artifacts (e.g., bronze objects) of archaeological interest.

Occupational exposure to electromagnetic fields and sex-differential risk of uveal melanoma.

Objectives: The association between occupational exposure to electromagnetic fields (EMF) and the risk of uveal melanoma was investigated in a case-control study in nine European countries.

Methods: Incident cases of uveal melanoma and population as well as hospital controls were included and frequency matched by country, 5-year birth cohort and sex. Subjects were asked whether they had worked close to high-voltage electrical transmission installations, computer screens and various electrical machines, or in complex electrical environments.

Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case-control study in Europe.

Objectives: Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment.

Association between genetic polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT genes and radiosensitivity in breast cancer patients.

Purpose: Clinical radiosensitivity varies considerably among patients, and radiation-induced side effects developing in normal tissue can be therapy limiting. Some single nucleotide polymorphisms (SNPs) have been shown to correlate with hypersensitivity to radiotherapy. We conducted a prospective study of 87 female patients with breast cancer who received radiotherapy after breast surgery.

Comparative evaluation of eight commercial human cytomegalovirus IgG avidity assays.

Background: The interpretation of a positive IgM antibody result to human cytomegalovirus (HCMV) in a pregnant woman is of major importance for the correct management of the pregnancy. Determination of HCMV-specific IgG avidity is considered an useful approach for distinguishing IgM antibody due to primary HCMV infection from IgM antibody elicited during non-primary infection.

Objective: Comparative evaluation of eight commercial HCMV IgG avidity assays currently available in Europe.

Hormonal exposures and the risk of uveal melanoma.

Objectives: Several studies suggest that hormonal mechanisms may be associated with the development of uveal melanoma. Therefore, the association between the risk of uveal melanoma and exposure to hormonal exposures was investigated in a case-control study from nine European countries.

Methods: Incident cases of uveal melanoma were frequency-matched to population and hospital controls by country, age, and sex.

Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.

In every synapse, a large number of proteins interact with other proteins in order to carry out signaling and transmission in the central nervous system. In this study, we used interaction proteomics to identify novel synaptic protein interactions in mouse cortical membranes under native conditions. Using immunoprecipitation, immunoblotting, and mass spectrometry, we identified a number of novel synaptic protein interactions involving soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), calcium-activated potassium channel (BKCa) alpha subunits, and dynamin-1.

[Workplace health promotion interventions: ongoing projects and evaluation of their effectiveness].

Background: The Italian law of January 2005 that banned smoking in enclosed public places, also banned smoking in the workplace.

Results: This law led to the elimination of exposure to passive smoking for non-smokers, more smokers who gave up smoking, and a fall in the number of cigarettes smoked per day among smokers. Enforcement of the ban needs to be strengthened in discotheques and at the workplace and in outdoor smoking premises.

A silicon photomultiplier readout for time of flight neutron spectroscopy with gamma-ray detectors.

The silicon photomultiplier (SiPM) is a recently developed photosensor used in particle physics, e.g., for detection of minimum ionizing particles and/or Cherenkov radiation.

On the relationship between smoking bans and incidence of acute myocardial infarction.

During the last few years several studies have reported a substantial reduction of acute myocardial infarction (AMI) in the general population few months after the enforcement of comprehensive smoking bans. We reviewed the consistency and plausibility of this association, investigating the effect of the Italian law, entered into force on January 10, 2005. We compared the AMI incidence on the first year after the ban with the period before (2000-2004) in the Tuscany population aged 30-64 years.

Gain stabilization control system of the upgraded magnetic proton recoil neutron spectrometer at JET.

Burning plasma experiments such as ITER and DEMO require diagnostics capable of withstanding the harsh environment generated by the intense neutron flux and to maintain stable operating conditions for times longer than present day systems. For these reasons, advanced control and monitoring (CM) systems will be necessary for the reliable operation of diagnostics. This paper describes the CM system of the upgraded magnetic proton recoil neutron spectrometer installed at the Joint European Torus focusing in particular on a technique for the stabilization of the gain of the photomultipliers coupled to the neutron detectors.

Exposure to benzene and risk of breast cancer among shoe factory workers in Italy.

Aims And Background: Evidence of the association between leukemia and benzene exposure has been provided by several epidemiological studies. An increased risk of breast cancer among women exposed to benzene has also been suggested. The aim of this study was to analyze breast cancer risk in a cohort of 1,002 women exposed to benzene in a shoe factory in Florence, Italy, where an excess of leukemia in men was reported.

Chronic vagus nerve stimulation induces neuronal plasticity in the rat hippocampus.

Vagus nerve stimulation (VNS) is used to treat pharmacotherapy-resistant epilepsy and depression. However, the mechanisms underlying the therapeutic efficacy of VNS remain unclear. We examined the effects of VNS on hippocampal neuronal plasticity and behaviour in rats.

Prevalence of second-hand smoke exposure after introduction of the Italian smoking ban: the Florence and Belluno survey.

Aims And Background: A law banning smoking in enclosed public places was implemented in Italy on January 10, 2005. The aim of this paper is to present a cross-sectional survey on two representative samples of non-smokers of two Italian towns (Florence and Belluno), conducted one year after the introduction of the ban, in order to assess prevalence of second-hand smoke exposure, to record the attitudes towards the ban, and the perception about its compliance in a representative sample of non-smokers.

Methods: Computer-assisted telephone interviews were carried out in March 2006, from a random sample of households from telephone registries.

Gastric cancer mortality trends in Tuscany, Italy, 1971-2004.

Unlabelled: AIMS, BACKGROUND, AND METHODS: In Tuscany, Italy, gastric cancer mortality has been decreasing since 1950, although with relevant geographical variability across the region. In Eastern Tuscan areas close to the mountains (high risk areas), gastric cancer mortality has been and is still significantly higher than that recorded in Western coastal areas and in the city of Florence (low risk areas). High-risk areas also showed higher Helicobacter pylori seroprevalence.

Towards a common disability assessment framework: theoretical and methodological issues for providing public services and benefits using ICF.

Purpose: To report on the preliminary results of an Italian project on the implementation of an ICF-based protocol for providing public services and benefits for persons with disabilities.

Methods: The UN Convention on the Rights of persons with disabilities (UNC) was mapped to the ICF, and core elements were implemented in an ICF-based evaluation protocol. A person-environment interaction classification (PEIC) tree was also developed for defining evaluation outputs.