IL-17/il-23 and Chlamydia trachomatis.

Ch. trachomatis is a gram negative bacteria, infecting the most organs of the uro-genital tract and harming greatly the woman's or man's reproductive field. Moreover, as this is not the limit of its destructive nature, it can form a favorable ground for developing ulcer and tumor processes.

The nitric oxide production in monocytes and macrophages of the Chlamydia trachomatis-infected patients depends on the IFN gamma and tnf alpha amount.

We studied the NO production in the peripheral blood monocytes in the Chlamydia trachomatis infected patients and in the macrophages located in the Chlamydia-caused inflammation centers. With this aim we have investigated 132 patients with Chlamydios and 85 probands for control group. The infections were identified by IFA, IFU and PCR.

Primary chlamydial infection correlates with high level of serum interleukin 12 (IL-12).

According to the existing data, cytokines actively participate in the pathogenesis of Chlamydia infection. However, the role of IL-12 in Chlamydiosis development has not been studied yet. The aim of our research is to define the role of IL-12 in the pathogenesis of the disease.

[Clinical studies of a medicament fertilogen in some forms of autoimmune infertiliti].

It is considered that origins of the sterility in approximately 25% couples are immune factors. Among them, most important role has autoimmune factors. Unfortunately, many issues of their appearance, influence and especially treatment are not clear and investigated.

[The characteristics of hormonal contraception in women with hyperandrogenism].

One hundred and ten fertile women with such androgenism signs as seborrhea, acne, and hirsutism were examined to elucidate the contraceptive and therapeutic efficacy of hormonal contraceptive drugs anteovin, marvelon, and diane-35. The duration of pill administration for each women depended on her cycle duration. All the drugs had a 100% contraceptive efficacy and exerted a therapeutic effect on androgenism symptoms.

[Characteristics of growth hormone secretion in the hyperprolactinemia syndrome].

A low basal level of growth hormone (GH) was determined by radioimmunoassay in studying GH basal content, the circadian rhythm and the response to glucose load in patients with hyperprolactinemia. In subjects with hypophyseal adenoma, an anomalous GH response to glucose load and the disturbance of its circadian rhythm are seen. In patients not suffering from hypophyseal adenoma, the circadian curve of GH content is similar to the normal one on a lower level.