Publications by authors named "Gorfil D"
Venous thromboembolic disease remains a leading cause of maternal morbidity and mortality. We report a case of a 30-year-old woman at 37 gestation with a history of thalassaemia intermedia and splenectomy. During pregnancy, she had been managed with frequent blood transfusions and enoxaparin.
View Article and Find Full Text PDFBackground: Cardiac surgery involving cardiopulmonary bypass induces a significant systemic inflammatory response, contributing to various postoperative complications, including pulmonary dysfunction, myocardial and kidney injuries.
Objective: To investigate the effect of Nitric Oxide delivery via the cardiopulmonary bypass circuit on various postoperative outcomes.
Design: A prospective, single-centre, double-blinded, randomised controlled trial.
Background: Adequate pain control following lung transplantation (LTx) surgery is paramount. Thoracic epidural analgesia (TEA) is the gold standard; however, the potential use of extracorporeal membrane oxygenation (ECMO) and consequent anticoagulation therapy raises safety concerns, prompting clinicians to seek safer alternatives. The utility of thoracic wall blocks in general thoracic surgery is well established; however, their role in the context of LTx has been poorly investigated.
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- The study analyzed the use of extracorporeal membrane oxygenation (ECMO) in pregnant women experiencing severe respiratory or circulatory failure across 10 hospitals in Israel over three years.
- Out of 540,234 live births, only 28 obstetric patients (5.2 per 100,000 births) were treated with ECMO, primarily for hypoxic respiratory failure due to conditions like ARDS, with COVID-19 being a significant factor.
- Despite the low incidence, ECMO resulted in high survival rates for both mothers (89.3%) and babies (100%), with complications being rare.
Article Synopsis
- - A study was conducted to validate a new automatic urine output monitoring device (Serenno Medical) against standard methods (urometer) in three ICUs, aiming to assess its accuracy in measuring urine output for evaluating fluid status and acute kidney injury (AKI).
- - The results showed that the Serenno device had a strong agreement with the camera-derived measurements, with a bias of -0.4 ml/h and a concordance rate of 92%, while the correlation with hourly nursing assessments was significantly poorer.
- - The findings indicated that the Serenno device could effectively monitor urine output with minimal supervision needed, and it highlighted issues with nursing staff missing severe oliguria events, suggesting it may enhance patient care in ICU settings.
Purpose: Vasopressin has become an important vasopressor drug while treating a critically ill patient to maintain adequate mean arterial pressure. Diabetes insipidus (DI) is a rare syndrome characterized by the excretion of a large volume of diluted urine, inappropriate for water homeostasis. We noticed that several COVID19 patients developed excessive polyuria suggestive of DI, with a concomitant plasma sodium-level increase and/or low urine osmolality.
View Article and Find Full Text PDFVentricular fibrillation, a life-threatening ventricular arrhythmia, may result in pulselessness, loss of consciousness and sudden cardiac death. In this case report, we describe our experience in managing a 54-year-old man with HeartMate3 left ventricular assist device (LVAD) as a bridge to transplantation due to dilated non-ischemic cardiomyopathy, presenting with incessant ventricular arrhythmia for 35 days despite multiple attempts to restore normal rhythm with external direct current cardioversion and anti-arrhythmic medications. The patient remained stable in ventricular arrhythmia with no progression to asystole, but hemodynamic collapse due to right heart failure occurred in the third week.
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- The published article contained errors in Table 1 due to issues during production.
- The specific errors involved incorrect values for FS and Body Weight in two different columns.
- The article has been updated to correct these errors and provide accurate information.
Article Synopsis
- Metabolic disorders like obesity and type 2 diabetes can lead to diabetic cardiomyopathy, characterized by heart muscle growth, mitochondrial dysfunction, and fibrosis influenced by angiotensin.
- In a study with diabetic mice, caloric restriction (CR) was shown to protect the heart against damage by reducing oxidative stress and inflammation, resulting in better cardiac health.
- The research found that CR preserved SIRT1 and PGC-1α activity, which are important for cellular defense, while inhibiting SIRT1 in heart cells decreased their protective effects, highlighting the role of these pathways in heart disease prevention.