Publications by authors named "Goretta Baldo"
Article Synopsis
- The study aimed to investigate the presence of different types of lipoprotein(a) [Lp(a)] isoforms and apo B in atherosclerotic plaque taken from patients undergoing carotid endarterectomy due to severe stenosis, analyzing differences based on gender and plaque stability.
- Researchers measured lipid levels, apo B, and Lp(a) in both serum and plaque samples from 80 participants and classified apo(a) isoforms by their kringle IV repeat structure.
- Findings revealed that female patients exhibited higher Lp(a) levels and lower apo B levels compared to males, with unstable plaques showing particularly elevated Lp(a) in females, alongside a distinct pattern of apo(a) isoform accumulation in plaque versus serum.
Background: Our aim was to identify the pancreatic cancer diabetogenic peptide.
Methods: Pancreatic tumor samples from patients with (n=15) or without (n=7) diabetes were compared with 6 non-neoplastic pancreas samples using SDS-PAGE.
Results: A band measuring approximately 1500 Da was detected in tumors from diabetics, but not in neoplastic samples from non-diabetics or samples from non-neoplastic subjects.
Background: Diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. Clinical, epidemiological, and experimental data indicate that pancreatic cancer causes diabetes mellitus by releasing soluble mediators which interfere with both beta-cell function and liver and muscle glucose metabolism.
Methods: We analysed, by matrix-assisted laser desorption ionization time of flight (MALDI-TOF), a series of pancreatic cancer cell lines conditioned media, pancreatic cancer patients' peripheral and portal sera, comparing them with controls and chronic pancreatitis patients' sera.
A rapid method to determine plasma homocysteine concentration and enrichment by gas chromatography/mass spectrometry.
Rapid Commun Mass Spectrom
March 2005
Homocysteine is an independent risk factor for cardio- and/or cerebrovascular diseases. Many methods are used to measure plasma homocysteine levels in physiological fluids. Current gas chromatographic/mass spectrometric (GC/MS) methods allow determination not only of plasma homocysteine concentration, but also of its turnover.
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