The delayed effects of irreversible electroporation ablation on nerves.

Objective: To evaluate the delayed effects of irreversible electroporation (IRE) ablation on nerves.

Methods: The study was approved by the institutional animal care and use committee. CT-guided IRE-ablation (electric field per distance, 1,500 V/cm; pulse length, 70 μs; number of pulses, 90) of 6 sciatic nerves was performed in 6 pigs that were euthanized 2 months after ablation.

Irreversible electroporation adjacent to the rectum: evaluation of pathological effects in a pig model.

Purpose: To evaluate the effects of irreversible electroporation (IRE) on the rectum wall after IRE applied adjacent to the rectum.

Material And Methods: CT-guided IRE adjacent to the rectum wall was performed in 11 pigs; a total of 44 lesions were created. In five pigs, ablations were performed without a water-filled endorectal coil (group A); in six pigs, ablation was performed with the coil to avoid displacement of the rectum wall (group B).

Acute and subacute effects of irreversible electroporation on nerves: experimental study in a pig model.

Purpose: To evaluate whether irreversible electroporation (IRE) has the potential to damage nerves in a porcine model and to compare histopathologic findings after IRE with histopathologic findings after radiofrequency ablation (RFA).

Materials And Methods: This study was approved by the institutional animal care and use committee. Computed tomography (CT)-guided IRE of 11 porcine sciatic nerves was performed in nine pigs, and histopathologic analysis was performed on the day of ablation or 3, 6, or 14 days after ablation.

Percutaneous irreversible electroporation lung ablation: preliminary results in a porcine model.

Objective: Irreversible electroporation (IRE) uses direct electrical pulses to create permanent "pores" in cell membranes to cause cell death. In contrast to conventional modalities, IRE has a nonthermal mechanism of action. Our objective was to study the histopathological and imaging features of IRE in normal swine lung.

Irreversible electroporation near the heart: ventricular arrhythmias can be prevented with ECG synchronization.

Objective: Irreversible electroporation is a nonthermal ablative tool that uses direct electrical pulses to create irreversible membrane pores and cell death. The ablation zone is surrounded by a zone of reversibly increased permeability; either zone can cause cardiac arrhythmias. Our purpose was to establish a safety profile for the use of irreversible electroporation close to the heart.

Renal tissue ablation with irreversible electroporation: preliminary results in a porcine model.

Objectives: To evaluate the histopathologic and computed tomography imaging features associated with irreversible electroporation (IRE) ablation performed in normal porcine kidneys. IRE is a nonthermal ablative tool that uses direct electrical pulses to create permanent "pores" in cell membranes and cell death. It does not affect the extracellular matrix.