Publications by authors named "Gordon Sidlow"
Article Synopsis
- Testosterone is primarily produced in the testes and is found in trace amounts in geldings due to adrenal secretion; the International Federation of Horseracing Authorities established a urine threshold of 20 ng/mL for preventing testosterone misuse in 1996.
- Recent testing methods in blood have led to the development of a new liquid chromatography-mass spectrometry method to measure low levels of free testosterone in gelding plasma, establishing a rounded threshold of 100 pg/mL.
- The effectiveness of this new plasma threshold was confirmed through studies, showing similar detection times in plasma and urine, and it was officially adopted by the IFHA in October 2013.
Background: Fluid secretion by sweat glands in response to heat and exercise is underpinned by increases in intracellular calcium. In horses, this is primarily via β2-adrenoceptors, but studies in equine sweat gland cell lines have indicated a possible role for purinergic agonists. Knowledge of equine sweating stimulus-secretion mechanisms in intact glands from healthy animals would allow future comparison to determine whether these mechanisms are affected in equine anhidrosis.
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