Usability of consumer product self-assembly instructions - a historical review of ergonomics research to create an international standard.

Selling products in kit form to consumers benefits both manufacturers and consumers - provided the instructions enable the customer to assemble the components correctly and safely. Poor usability of some self-assembly instructions is a continuing cause of consumer complaints- but the subject of only occasional ergonomics research interest. Relevant studies are widely dispersed across the literature - and across decades - but their findings generally agree on what makes some self-assembly illustrations more effective than others.

A reusable QCR aptasensor for the detection of Brevetoxin-2 in shellfish.

Brevetoxins (BTX) are pharmacologically active, lipid soluble cyclic polyether neurotoxins that are known to cause a wide range of neurological symptoms in humans.Harvesting and consumption of infected molluscs provide an entry point for BTXs into, the food chain, causing long-term health effects on accumulation for individuals, commonly in people with a compromised immune system and existing allergies. This study is an acoustic assay that has been constructed using a 9 MHz AT-cut quartz crystal resonator modified by attaching a specific single-stranded DNA aptamer.

Antiproliferative activity of Ontario grown onions against colorectal adenocarcinoma cells.

Cancer is the leading cause of mortality in Canada and other industrialized nations; the development of new/improved cancer therapies is desperately needed and continues to be a major focus of cancer research. Flavonoids, which are found in high levels in onions, have been shown to exert antiproliferative and potentially anti-cancer activities. To test their therapeutic potential, we assessed the antiproliferative, cytotoxic, apoptosis-inducing, and anti-migratory activities of five onion varieties grown in Ontario against human adenocarcinoma (Caco-2) cells.

Enhancing the bandwidth of piezoelectric composite transducers for air-coupled non-destructive evaluation.

This paper details the development of a novel method for increasing the operational bandwidth of piezocomposites without the need for lossy backing material, the aim being to increase fractional bandwith by geometrical design. Removing the need for lossy backing materials, should in turn increase the transmit efficiency in the desired direction of propagation. Finite element analysis has been employed to determine the mode of operation of the new piezocomposite devices and shows good correlation with that derived experimentally.

A simultaneous assessment metric for MAb quantity and glycan quality.

As a critical quality attribute, glycosylation represents an important consideration when analyzing the success of a glycoprotein production process. Though critical, glycosylation is not the only measure of culture success; other factors, including culture size, maintenance, and productivity, are also critical. A new metric was developed to address both product quality, as measured through glycosylation, and product quantity, as measured through product concentration.

Time-of-flight measurement techniques for airborne ultrasonic ranging.

Airborne ultrasonic ranging is used in a variety of different engineering applications for which other positional metrology techniques cannot be used, for example in closed-cell locations, when optical line of sight is limited, and when multipath effects preclude electromagnetic-based wireless systems. Although subject to fundamental physical limitations, e.g.

Ultrasound nondestructive evaluation (NDE) imaging with transducer arrays and adaptive processing.

This paper addresses the challenging problem of ultrasonic non-destructive evaluation (NDE) imaging with adaptive transducer arrays. In NDE applications, most materials like concrete, stainless steel and carbon-reinforced composites used extensively in industries and civil engineering exhibit heterogeneous internal structure. When inspected using ultrasound, the signals from defects are significantly corrupted by the echoes form randomly distributed scatterers, even defects that are much larger than these random reflectors are difficult to detect with the conventional delay-and-sum operation.

Properties of photocured epoxy resin materials for application in piezoelectric ultrasonic transducer matching layers.

This paper describes the acoustic properties of a range of epoxy resins prepared by photocuring that are suitable for application in piezoelectric ultrasonic transducer matching layers. Materials, based on blends of diglycidyl ether of Bisphenol A and 1,4-cyclohexanedimethanol diglycidyl ether, are described. Furthermore, in order to vary the elastic character of the base resin, samples containing polymer microspheres or barium sulfate particles are also described.

Simulation of ultrasonic lamb wave generation, propagation and detection for a reconfigurable air coupled scanner.

A computer simulator, to facilitate the design and assessment of a reconfigurable, air-coupled ultrasonic scanner is described and evaluated. The specific scanning system comprises a team of remote sensing agents, in the form of miniature robotic platforms that can reposition non-contact Lamb wave transducers over a plate type of structure, for the purpose of non-destructive evaluation (NDE). The overall objective is to implement reconfigurable array scanning, where transmission and reception are facilitated by different sensing agents which can be organised in a variety of pulse-echo and pitch-catch configurations, with guided waves used to generate data in the form of 2-D and 3-D images.

Theoretical analysis of ultrasonic vibration spectra from multiple particle-plate impacts.

Many industrial processes involve particles in a carrier fluid, and it is often of interest to monitor the size of these particles noninvasively. The aim of this paper is to develop a theoretical model of multiple particle-wall impact vibrations that can be used to recover the particle size from experimental data. These vibrations have been measured by an ultrasonic transducer attached to the exterior of a vessel containing a stirred-particle-laden fluid.

Estimating particle concentration using passive ultrasonic measurement of impact vibrations.

A method of obtaining particle size and concentration information, from ultrasonic transducer measurements of particle-wall interactions in a particle laden fluid, is presented. A mathematical model of the flexural vibrations of the vessel wall due to the particle impact is constructed. The key component of this model is the derivation of an analytic expression for the impact force amplitude.

Simplex optimization of acoustic assay for plasminogen activators.

This article discusses the optimization of a newly developed method for measuring the activity of plasminogen activators using a thickness-shear-mode acoustic sensor. A variable-size simplex algorithm was used for optimization. Preliminary tests were performed to design the first simplex.

Acoustic determination of performance and equivalence of plasminogen activators.

A reliable method for the measurement of different plasminogen activators is of great interest for both manufacturing and clinical medicine. A one-step assay based on a thickness shear mode acoustic sensor has been developed for this purpose. Two separate mixtures of substrates (fibrinogen and plasminogen) and enzymes (thrombin and the plasminogen activator) were mixed, and placed on the acoustic sensor surface.

One-step thickness shear mode acoustic assay for plasminogen activators.

A new procedure is presented for the measurement of plasminogen activators using a thickness shear mode sensor and a modified version of the fibrin plate assay at the micro-scale. Separate, well-mixed solutions of the substrates fibrinogen and plasminogen, and enzymes thrombin and the plasminogen activator sample were mixed together and placed on the sensor surface. The temperature and evaporation were controlled during the assay.

Harmonic analysis of lossy, piezoelectric composite transducers using the plane wave expansion method.

Periodic composite ultrasonic transducers offer many advantages but the periodic pillar architecture can give rise to unwanted modes of vibration which interfere with the piston like motion of the fundamental thickness mode. In this paper, viscoelastic loss is incorporated into a three-dimensional plane wave expansion model (PWE) of these transducers. A comparison with experimental and finite element data is conducted and a design to damp out these lateral modes is investigated.

Finite element technique for the assessment of 3-1 and "super 1-3" connectivity piezoelectric composite transducers.

This paper describes the use of finite element (FE) technique in the assessment of new types of multilayered piezoelectric composite structure using the PZFlex code. The background information leading to model configuration, including materials properties and boundary conditions, is discussed. This is coupled with an experimental program of model corroboration via a number of key stage prototypes to achieve a model-build-test methodology.

Theoretical modelling of frequency dependent elastic loss in composite piezoelectric transducers.

The large number of degrees of freedom in the design of piezoelectric transducers requires a theoretical model that is computationally efficient so that a large number of iterations can be performed in the design optimisation. The materials used are often lossy, and indeed loss can be used to enhance the operational characteristics of these designs. Motivated by these needs, this paper extends the one-dimensional linear systems model to incorporate frequency dependent elastic loss.

A theoretical analysis of a piezoelectric ultrasound device with an active matching layer.

This paper investigates the use of magnetically active materials in the matching layer of a piezoelectric transducer. This then allows the performance of the device to be dynamically altered by applying an external field. The effect that this new matching layer has on the performance of a typical device is theoretically investigated here.

Comparison of the frequency and physical nature of the lowest order parasitic mode in single crystal and ceramic 2-2 and 1-3 piezoelectric composite transducers.

This work describes an investigation into the first order parasitic mode (i.e., that closest to the fundamental thickness mode) that can occur in 2-2 and 1-3 thickness drive piezoelectric composite transducers.

A block diagram model of the thickness mode piezoelectric transducer containing dual oppositely polarized piezoelectric zones.

A unidimensional, linear systems, block diagram model of a two-layer thickness mode piezoelectric transducer is presented. The layers are subject to opposing piezoelectric polarization and the device is assumed to be loaded by semi-infinite isotropic media at the two principal faces. Block diagram representations of the transducer acting as both a generator and a receiver of ultrasound are developed in conjunction with the equivalent model of the electrical admittance.

Determination of lamb wave dispersion data in lossy anisotropic plates using time domain finite element analysis. Part II: application to 2-2 and 1-3 piezoelectric composite transducer arrays.

The use of finite element modeling, combined with optical generation and detection of Lamb waves in plate structures, was extended to encompass periodic ceramic-polymer materials typical of those encountered in 1-3 and 2-2 piezoelectric composite array transducers. The resultant dispersion data was employed to predict the occurrence of Lamb wave-induced cross talk in composite monolithic arrays. The finite element modeling method was then used to simulate the dispersion behavior of two array structures that were subsequently manufactured: a 1-D 45% volume fraction linear array coupon and a 2-D 35% volume fraction array coupon.

Determination of lamb wave dispersion data in lossy anisotropic plates using time domain finite element analysis. Part I: theory and experimental verification.

A theoretical and experimental approach for extraction of guided wave dispersion data in plate structures is described. Finite element modeling is used to calculate the surface displacement data (in-plane and out-of-plane) when the plate is subject to either symmetrical or antisymmetrical impulsive force stimulation at one or both of the parallel faces. Fourier transformation of the resultant space-time displacement histories is then employed to obtain phase velocity as a function of frequency.

Factors affecting broadband acoustic emission measurements of a heterogeneous reaction.

Broadband acoustic emission signals were obtained by attaching a piezoelectric transducer, sensitive up to 750 kHz, to the external wall of a 1 L jacketed glass reactor. Measurements were acquired of itaconic acid particles mixing in toluene; the total area of the acoustic emission signal from 55-500 kHz increased when the particle concentration, particle size or stir rate were increased. Signals at frequencies above 200 kHz were less sensitive to changes in particle size than those at lower frequencies.

A flexible piezoelectric transducer design for efficient generation and reception of ultrasonic Lamb waves.

This paper describes the development of a flexible piezoelectric transducer for the generation and detection of ultrasonic symmetrical Lamb waves in plate-like structures. This piezoplatelet transducer structure comprises an array of miniature piezoceramic plates embedded within a soft setting polymer filler material, combining the efficiency of the active piezoceramic phase with a degree of flexibility, which is a function of the platelet/polymer dimensions. For many condition-monitoring applications, the generation of ultrasonic Lamb waves is often appropriate, and this was achieved by incorporating interdigital design techniques via the transducer electrode pattern.

Improving the thermal stability of 1-3 piezoelectric composite transducers.

The effect of temperature on the behavior of 1-3 piezoelectric composites manufactured using various polymeric materials was assessed experimentally through electrical impedance analysis and laser vibrometry. Device behavior varied with temperature irrespective of the polymer filler. Most significant changes in the piezoelectric composites were recorded around the glass transition temperature (Tg) of the polymer; movement to lower fundamental resonant frequencies and higher values of electrical impedance minima were observed at higher temperatures.