Complete pathologic response rate to neoadjuvant chemotherapy increases with increasing HER2/CEP17 ratio in HER2 overexpressing breast cancer: analysis of the National Cancer Database (NCDB).

Background: HER2-positive breast cancer is an aggressive subtype of breast cancer that overexpresses human epidermal growth factor receptor 2 promoting cancer cell growth. Monoclonal antibodies targeting the HER2 receptor have improved survival for this patient population. Achieving pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) has correlated with disease-free survival in multiple trials, but we do not know why some HER2-positive tumors respond better to these therapies.

Assessment of aggressiveness of prostate cancer: correlation of apparent diffusion coefficient with histologic grade after radical prostatectomy.

Objective: The purpose of this article is to evaluate the relationship between apparent diffusion coefficient (ADC) values, tumor volume, and total Gleason grade in patients with prostate cancer before radical prostatectomy.

Materials And Methods: A total of 110 patients with prostate cancer who had undergone endorectal prostate MRI at 1.5 T before radical prostatectomy were included.

Extension of ovarian tissue into the infundibulopelvic ligament beyond visual margins.

Objective: The purpose of our study was to identify microscopic margins of the ovary and possible extension of the ovarian tissue beyond visual margins into the infundibulopelvic (IP) tissue to formulate recommendations for adequate salpingo-oophorectomy.

Methods: An observational study was conducted with thirty female patients who underwent bilateral salpingo-oophorectomy (BSO) as part of their procedure at Bethesda North Hospital between September 2007 and May 2008.

Results: Thirty patients underwent BSO as part of their primary procedure.