Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332).

The characterization of an isolate of swine infertility and respiratory syndrome (SIRS) virus (ATCC VR-2332) is reported. A commercial cell line (CL2621) was used for the propagation of the virus for all assays. Laboratory studies indicate that this isolate is a fastidious, nonhemagglutinating, enveloped RNA virus.

Experimental reproduction of swine infertility and respiratory syndrome in pregnant sows.

The purpose of this study was to experimentally reproduce swine infertility and respiratory syndrome (SIRS). Six multiparous sows were intranasally inoculated at 93 days of gestation with lung homogenates from clinically affected pigs, and 3 additional sows were similarly inoculated with a virus isolated in cell culture from the lung homogenate (SIRS virus, isolate ATCC VR-2332). Inoculated sows developed transient anorexia, farrowed up to 7 days prematurely, and delivered a mean of 5.

The immune response of allophenic mice to the synthetic polymer GL phi. III. Allotype analysis of anti-GL phi antibody.

Allophenic mice produced by aggregating 8-cell embryos from a low responder (CBA) and a high responder (DBA/1) strain to the synthetic amino acid polymer GL phi.. In some strains of mice the immune response to this polymer is controlled by two genes, alpha and beta, which map to the IE/C and IA subregions of the H-2 complex, respectively.