Enantioselective Synthesis of Dihydrobenzofurans, Dihydrobenzosulfones, and Dihydroindoles by Merging One-pot Intramolecular Heck-Matsuda Reactions from Anilines with Redox-Relay Process.

A one-pot tandem process was developed aiming at the concise and expeditious enantioselective synthesis of dihydrobenzofuran, dihydrobenzosulfone, and dihydroindole scaffolds under mild, and open-flask conditions. This process combines the in situ generation of aryldiazonium salt directly from the anilines in methanol telescoped to an intramolecular Heck-Matsuda reaction linked to a redox relay process to provide the final products as the dimethyl acetals. These Heck products were smoothly converted into the corresponding primary alcohols or esters.

Enantioselective synthesis of β-aryl-γ-lactam derivatives via Heck-Matsuda desymmetrization of -protected 2,5-dihydro-1-pyrroles.

We report herein an enantioselective palladium-catalyzed Heck-Matsuda reaction for the desymmetrization of -protected 2,5-dihydro-1-pyrroles with aryldiazonium salts, using the chiral ,-ligand ()-PyraBox. This strategy has allowed straightforward access to a diversity of 4-aryl-γ-lactams via Heck arylation followed by a sequential Jones oxidation. The overall method displays a broad scope and good enantioselectivity, favoring the () enantiomer.

[Global demographic problem and active aging (literature review)].

The article presents an overview of foreign sources devoted to the problems of population aging as a significant phenomenon that has become the most important medical and socio-demographic challenge in the world. The review provides global data on this problem and shows the need for elaborating and implementing active aging strategies, optimizing opportunities for health, participation and safety in order to improve the life quality as people age. The paper employs the method of content analysis of scientific publications retrieved in PubMed database by keywords - «aging», «population aging», «demographic trend», «longevity», and «life expectancy».

[DETERMINING THE LEVEL OF TECHNOLOGICAL READINESS OF DEVELOPMENTS IN MEDICINE BASED ON THE TRL METHODOLOGY].

The article discusses an approach to assessing the level of maturity of medical technologies based on the TRL (technology readiness level) methodology. The author presents a tool for planning scientific results and developments in the direction of «medical sciences» with a clear description of the expected results at each level of research and development. The levels of technological maturity of developments in the field of healthcare are described in detail, possible results and reporting forms for each level are presented, their differences are analyzed depending on the planned final product.

Get Noticed to Get Ahead: The Impact of Personal Branding on Career Success.

There is a growing amount of attention being brought to personal branding as an effective career behavior, but little is known about the factors that predict personal branding behaviors and their outcomes. In two studies ( = 477) across two distinctly different cultural contexts (Western and Asian) based on a newly developed and validated scale of personal branding, we have examined the antecedents and outcomes of personal branding. The findings confirm that personal branding leads to greater career satisfaction, fully mediated by perceived employability.

Steroidal N-Sulfonylimidates: Synthesis and biological evaluation in breast cancer cells.

Unique derivatives of androstene and estrane series containing N-sulfonylimidate pendants were prepared from 17α-ethynyl steroids via Cu-catalyzed azide-alkyne cycloaddition to tosyl azide in the presence of alcohols. The synthesized compounds were screened for cytotoxicity against human breast cancer cell lines and ERα agonist activity. The hit compound 3,17β-dimethoxy-17α-[iso-propyl-2'-N-tosylacetimidate]estra-1,3,5-triene (4n) had no ERα-mediated hormonal activity and was found to exhibit potent cytotoxic effect in an ERα-positive breast cancer cell line.

Personal Branding: Interdisciplinary Systematic Review and Research Agenda.

Personal branding has become an important concept in management literature in recent years. Yet, with more than 100 scholarly papers published on the concept to date, it has developed into a fragmented area of research with a diversity of definitions and conceptual boundaries. This paper posits that this heterogeneity of extant research impedes theoretical and empirical advancement.