[Oxidative stress, rRNA genes, and antioxidant enzymes in pathogenesis of schizophrenia and autism: modeling and clinical advices].

Ribosomal genes (RG), or genes for rRNA, are represented by multiple tandem repeats in eukaryotic genomes, and just a part of them is transcriptionally active. The quantity of active copies is a stable genome feature which determines the cell's capability for rapid synthesis of proteins, necessary to cope with stress conditions. Low number of active RG copies leads to reduced stress resistance and elevated risk of multifactorial disorders (MFD).

[Differences in the EEG synchrony between healthy children and adolescents and patients with schizophrenia].

In this paper, we have used a method for EEG synchrony estimation (an analysis of correlation synchrony of EEG. EEG recording was performed in a group of children and adolescents, aged 8-15 years, normal group (n=40) and schizophrenic group (n=30). One of the basic features of the integrated EEG picture is the presence of a pathology of extended zones of sharply lowered EEG-synchrony dividing the local and isolated areas in frontal and occipital regions, mainly of normal or sometimes raised synchrony.

[The importance of biological and social factors in school success].

Three groups of children with learning difficulties (a total of 62 children) are dealt with in this study according to their cognitive and psychological special features. In the first group the difficulties are a symptom of the FMR1-gene dysfunction. In the second group the poor school performance is associated with social interaction problems and high intelligence level.

[Variations of heterochromatic chromosomal regions and chromosome abnormalities in children with autism: identification of genetic markers in autistic spectrum disorders].

In the present study, the cytogenetic and molecular cytogenetic analysis of 90 children with autism and their mothers (18 subjects) was carried out. Chromosome fragility and abnormalities were found in four cases: mos 47,XXX[98]/ 46,XX[2]; 46,XY,r(22)(p11q13); 46,XY,inv(2)(p11.2q13),16qh-; 46Y,fra(X)(q27.

[Segmental structure of the EEG alpha activity in adolescents with disorders of schizophrenic spectrum].

The EEG records of 39 healthy adolescents and 45 age-matched schizophrenic patients were analyzed. The broad-band EEG spectral analysis and segmental analysis of the alpha-activity revealed significant differences between the groups. Schizophrenics differed in a decreased spectral power for the alpha2 and betal frequency bands and increased power for the delta and theta bands.

[Quantitative EEG correlates of the human frontal lobe dysfunction].

Increased central-parietal EEG theta-2 activity (about 6.5 per sec) was found in children with cognitive disorders (in Rett's syndrome, fragile X-syndrome, infantile autism) and in elderly patients with Alzheimer-type dementia (with prevalence of neuropsychological "frontal" disorders) in the presence of suppressed alpha rhythm. This theta-activity was closely associated with cognitive deficits and possessed a specific functional topography, namely it focused in the parietal region and suppressed by both visual stimulation and motor tests.

[Speech and motor disorders in Rett syndrome].

Rett syndrome (RS) is a severe genetically conditioned disorder of an early childhood with an definite clinical phenotype in girls. Motor and speech disturbances are noted as the essential part of RS clinical picture. The variability of motor dysfunction and degree of speech deterioration were noted at different stages of the illness.

[Brain bioelectrical activity in patients with the fragile X-chromosome syndrome and in their mothers].

30 patients (4-22 years old) and their 12 mothers were examined by means of method of electroencephalography (EEG). Healthy individuals of corresponding age were included in the control group. EEG changes of the same type were observed in all the patients with syndrome of fragile X-chromosome: reduction of occipital alpha-rhythm, prevalence of theta-rhythm in central-parietal and central frontal regions as well as epileptoid activity in parietal and central-parietal cortical regions.

[An elevation in the level of autoantibodies to nerve-growth factor in the blood serum of schizophrenic children].

The level of autoantibodies (AAB) to nerve growth factor (NGF) was examined in blood of mentally healthy children, children with early children schizophrenia as well as with Kanner's and Asperger's syndromes too. The elevated titer of AAB to NGF was determined in blood of children with acute, active state of disease; meanwhile the same titer wasn't changed in the state of stable remission or steady defective state as compared with control group. The correlation was found between the level of AAB to NGF and the degree of disease progression.

[The clinical, neurophysiological and differential diagnostic aspects in a study of severe forms of early childhood autism].

Clinical, pathopsychological and neurophysiological studies have been carried out in 85 children with infantile autistic psychosis and in 38 girls with Rett's syndrome. New improved differential diagnostic criteria between these two forms of early childhood autism have been suggested. EEG spectral density values in alpha-1, alpha-2, beta and theta subbands are established to be their neurophysiological markers.

[The clinical and neurophysiological aspects of Rett's syndrome].

36 children with Rett's syndrome were examined in respect to the illness stage and psychopathologic trends. It is supposed that relationship of EEG abnormalities to clinical stages reflects gradual involvement of different brain structures in the pathological process. Possibility of temporary interruptions in the disease progression is demonstrated.

[Various neurophysiological aspects of examination of children with Gilles de la Tourette's syndrome].

EEG mapping was used to study the ECG and brain electric activity in 45 normal children and in 33 patients with Gilles de la Tourette's syndrome. Significant differences were discovered in the test parameters in groups of patients and normal children as well as in subgroups of patients with different varieties of the syndrome. Analysis of the ECG has shown that 78% of children with typical Tourette's syndrome manifest neurovegetative regulation impairment in the form of bradycardia and cardiac arrhythmia.

[Dynamics of the development of EEG responses in school age boys and girls (data of observations over 9 years)].

The EEGs were recorded four times with an interval of 3 years in 25 children. There were 13 boys and 12 girls aged 8 to 17 years (forms 1-10). During data processing, use was made of the frequency and amplitude analysis of the EEG.

[Neuropsychological study of memory in the complex clinical, psychological and neurophysiologic examination of children with schizophrenia].

Combined clinical, psychologic and neurophysiological investigation was conducted in children with slow-progredient schizophrenia: with dominant affective disorders and hypomaniac states (Group I, 14 patients), and with predominant neurosis-like and psychopathy-like pathology (Group II, 12 patients). The patients distinctly differed in not only the clinical course of the disease but also according to neuropsychological investigations of memory, pathopsychological and EEG studies. These data are reliably intercorrelated.