Publications by authors named "Goran van der Weiden"
Background: Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in serum levels for N-terminal (NT) SIRT1 vs. C-terminal (CT) SIRT1, indicative of early signs of OA. Here we tested NT/CT SIRT1 levels as well as a novel formulated sandwich assay to simultaneously detect both domains of SIRT1 in a manner that may inform us about the levels of full-length SIRT1 in the circulation (flSIRT1) of clinical cohorts undergoing knee joint distraction (KJD).
View Article and Find Full Text PDFArticle Synopsis
- - Osteochondritis dissecans (OCD) is a rare knee condition where a piece of bone separates from the surrounding bone, potentially causing joint issues; the exact cause remains unclear, though various biological and mechanical factors are thought to contribute.
- - A study analyzed data from 236 patients with OCD to understand its prevalence and influencing factors, revealing that most lesions occurred in the medial femoral condyle and were linked to sports activity, particularly high-impact sports.
- - The study established a scoring system to assess the risk of instability in OCD patients based on factors like age, smoking, sports involvement, and past injuries, highlighting the need for further exploration into the disorder's causes.
Background: Osteochondritis dissecans (OCD) is a disorder originating in the subchondral bone, leading to focal lesions with risk of fragmentation and secondary damage of the articular cartilage. It remains controversial if surgical treatment of such lesions is equally successful in skeletally immature and mature patients.
Purpose: To determine (1) the long-term clinical success rate after internal fixation of unstable OCD in skeletally immature and mature patients based on physeal status, (2) if patient-specific and procedural variables influence the risk of failure, and (3) patient-reported outcome measures over time.