Association of Orai1 and Peizo1 genes expression with cellular proliferation, metastasis and angiogenesis biomarkers in colon tumor biopsies of CRC patients.

Colon cancer is a complex malignancy characterized by intricate molecular interactions that influence its progression. This study investigates the role of calcium channel gene expression (ORAI1 and Piezo1) and their interplay with angiogenesis-related genes (VEGFA, CCL3, and NF-KB1) in colon cancer tissue biopsies. Additionally, we explore the mutation profiles of pivotal oncogenes (KRAS, PI3KCA, and BRAF) and their potential correlations with calcium channel and angiogenesis-related gene expression.

Lack of association between the rs1800779 (A/G) polymorphism and the myocardial infarction incidence among the Iraqi Kurdish population.

Objectives: The genetic polymorphisms of the endothelial nitric oxide synthase () gene are strongly associated with several cardiovascular diseases (CVDs) in various populations. The current study aimed to investigate the association of the rs1800779 (A/G) polymorphism with the progress of myocardial infarction (MI).

Methods: Eighty-five healthy subjects and 80 patients with MI admitted to the Erbil Cardiac Centre in the Kurdistan Region of Iraq were enrolled in the study.

Recent findings on the role of wild-type and mutant p53 in cancer development and therapy.

The p53 protein is a tumor suppressor encoded by the TP53 gene and consists of 393 amino acids with four main functional domains. This protein responds to various cellular stresses to regulate the expression of target genes, thereby causing DNA repair, cell cycle arrest, apoptosis, metabolic changes, and aging. Mutations in the TP53 gene and the functions of the wild-type p53 protein (wtp53) have been linked to various human cancers.

Nanoformulation of Polyphenol Curcumin Enhances Cisplatin-Induced Apoptosis in Drug-Resistant MDA-MB-231 Breast Cancer Cells.

Triple Negative Breast Cancer (TNBC) is the aggressive and lethal type of breast malignancy that develops resistance to current therapies. Combination therapy has proven to be an effective strategy on TNBC. We aimed to study whether the nano-formulation of polyphenolic curcumin (Gemini-Cur) would affect the cisplatin-induced toxicity in MDA-MB-231 breast cancer cells.

Vitamin K1 As A Potential Molecule For Reducing Single-Walled Carbon Nanotubes-Stimulated α-Synuclein Structural Changes And Cytotoxicity.

Aims: Different kinds of vitamins can be used as promising candidates to mitigate the structural changes of proteins and associated cytotoxicity stimulated by NPs. Therefore, the structural changes of α-syn molecules and their associated cytotoxicity in the presence of SWCNTs either alone or co-incubated with vitamin K1 were studied by spectroscopic, bioinformatical, and cellular assays.

Methods: Intrinsic and ThT fluorescence, CD, and Congo red absorption spectroscopic approaches as well as TEM investigation, molecular docking, and molecular dynamics were used to explore the protective effect of vitamin K1 on the structural changes of α-syn induced by SWCNTs.