Mechanochemical Reactions from Individual Impacts to Global Transformation Kinetics.

Typically induced by the mechanical processing of powders in ball mills, mechanochemical transformations are considered to result from the application of mechanical force to solid reactants. However, the undeniable deep connection between the dynamic compaction of powders during impacts and the overall transformation degree has yet to be disclosed. In the present work, we show that the square planar bis(dibenzoylmethanato)Ni coordination compound undergoes trimerization when its powder experiences even a single ball impact.

Mechanochemical vs Wet Approach for Directing CO Capture toward Various Carbonate and Bicarbonate Networks.

The distinct research areas related to CO capture and mechanochemistry are both highly attractive in the context of green chemistry. However, merger of these two areas, , mechanochemical CO capture, is still in an early stage of development. Here, the application of biguanidine as an active species for CO capture is investigated using both solution-based and liquid-assisted mechanochemical approaches, which lead to a variety of biguanidinium carbonate and bicarbonate hydrogen-bonded networks.

Using Desmotropes, Cocrystals, and Salts to Manipulate Reactivity in Mechanochemical Organic Reactions.

Performing reactions in the solid state offers the largely unexplored possibility of influencing reactivity by manipulating the solid form of the starting reactants. In this work, we explore the use of various solid forms of barbituric acid and its effect on reaction paths and kinetics in a Knoevenagel condensation reaction with vanillin. Modifications of barbituric acid included the use of its desmotrope, a cocrystal, and a salt as the starting reactant.

Stereochemistry of Hexacoordinated Zn(II), Cu(II), Ni(II), and Co(II) Complexes with Iminodiacetamide Ligands.

Metal complexes of iminodiacetamide () ligands and metal ions Zn(II), Cu(II), Ni(II), and Co(II) were prepared using eight ligands (-) substituted with groups of different steric and electronic properties on the central amine N atom (H atom, methyl, isopropyl, and benzyl) and the para position of the phenyl rings (nitro and dimethylamino). The effect of these substituents on the stoichiometry ( and ), geometry, and stereochemistry (, -, -) of the complexes was studied in the solid state, in solution, and by density functional theory calculations. Single-crystal and powder X-ray diffraction, thermogravimetry, and IR spectroscopy showed that in the solid state ligands preferentially form - complexes, with the exception of the - complex .

[Successful treatment of polymedicamentous poisoning with metoprolol, diltiazem and cilazapril].

Introduction: Poisoning caused by drugs with cardiodepressive effects is an urgent condition in medicine which is associated with high mortality rate regardless of modern therapeutic methods. Accidental or intentional poisoning whit these drugs produces heart activity depression and cardiovascular collapse as consequences. Current therapy for severe poisoning caused by beta-blockers and calcium channel blockers includes both unspecific and specific antidote therapy whit glucagon, as well as application of adrenergic drugs, calcium, phosphodiesterase inhibitors and hyperinsulinemia/euglycemia therapy.