Vertical bone augmentation using collagenated or non-collagenated bone substitute materials with or without recombinant human bone morphogenetic protein-2 in a rabbit calvarial model.

Purpose: The aim of this study was to determine 1) the bone-regenerative effect of porcine bone block materials with or without collagen matrix incorporation, 2) the effect of a collagen barrier, and 3) the effect of adding recombinant human bone morphogenetic protein-2 (rhBMP-2) to the experimental groups.

Methods: Four treatment modalities were applied to rabbit calvaria: 1) deproteinized bovine bone mineral blocks (DBBM), 2) porcine bone blocks with collagen matrix incorporation (PBC), 3) porcine bone blocks alone without collagen matrix incorporation (PB), and 4) PBC blocks covered by a collagen membrane (PBC+M). The experiments were repeated with the addition of rhBMP-2.

Soft-tissue dimensional change following guided bone regeneration on peri-implant defects using soft-type block or particulate bone substitutes: 1-year outcomes of a randomized controlled clinical trial.

Aim: To compare the peri-implant soft-tissue dimensional changes following guided bone regeneration between particulate (particle group) and collagenated soft-block-type (block group) biphasic calcium phosphate (BCP).

Materials And Methods: This study investigated 35 subjects: 18 in the particle group and 17 in the block group. Cone-beam computed tomography obtained at 6 months post surgery and optical impressions taken periodically (before surgery, 6 months post surgery, and 1 year post surgery) were superimposed.

Randomized controlled clinical trial comparing guided bone regeneration of peri-implant defects with soft-type block versus particulate bone substitutes: Six-month results of hard-tissue changes.

Aim: To test whether soft-type block bone substitute used for guided bone regeneration (GBR) of peri-implant defects leads to a different dimension of the augmented hard tissue than particulate bone substitute.

Materials And Methods: In 40 patients, 40 two-piece dental implants were placed >2 months after tooth extraction. Following random allocation, 20 peri-implant bone dehiscences were grafted with a soft-type block made of synthetic biphasic calcium phosphate (BCP) + collagen and 20 bone dehiscences with particulate BCP.

Effect of collagen membrane and of bone substitute on lateral bone augmentation with titanium mesh: An experimental in vivo study.

Aim: The aim of this study was to identify the additional effects of collagen membrane (CM) and of synthetic bone substitute (BS) on lateral bone augmentation of chronic peri-implant defect with titanium mesh (TM).

Materials And Methods: Atrophic alveolar ridge was induced in six canine mandibles, and 5 peri-implant defects were achieved in each hemi-mandible. Bone augmentation was attempted using the following randomly allocated modalities: (1) Control: no treatment, (2) TM only group: blood clot covered by TM, (3) TM+BS group: BS covered by TM, (4) TM+CM group: blood clot covered by TM and CM, and (5) TM+BS+CM group: BS covered by TM and CM.

Effectiveness of xenogeneic and synthetic bone-block substitute materials with/without recombinant human bone morphogenetic protein-2: A preclinical study using a rabbit calvarium model.

Aim: To investigate new bone (NB) formation by using bone-block substitute materials with/without recombinant human bone morphogenetic protein-2 (rhBMP-2).

Materials And Methods: Three synthetic bone-block substitute materials [biphasic calcium phosphate (BCP); nanostructured hydroxyapatite (NH); 3D-printed tricalcium phosphate/hydroxyapatite (3DP)] and one xenogeneic deproteinized bovine bone mineral (DBBM) block substitute were affixed to rabbit calvarium using osteosynthesis screws, either with rhBMP-2 (n = 12) or without rhBMP-2 (n = 16). At 2 or 12 weeks (n = 6 with rhBMP-2 and n = 8 without rhBMP-2 for each week), histologic, histomorphometric and microcomputed tomography analyses were performed.

Trueness of ten intraoral scanners in determining the positions of simulated implant scan bodies.

Few investigations have evaluated the 3-dimensional (3D) accuracy of digital implant scans. The aim of this study was to evaluate the performance of 10 intraoral scanners (IOSs) (CEREC Omnicam, CEREC Primescan, CS 3600, DWIO, i500, iTero Element, PlanScan, Trios 2, Trios 3, and True Definition) in obtaining the accurate positions of 6 cylinders simulating implant scan bodies. Digital scans of each IOS were compared with the reference dataset obtained by means of a coordinate measuring machine.

Trueness of intraoral scanners in digitizing specific locations at the margin and intaglio surfaces of intracoronal preparations.

Statement Of Problem: Studies evaluating the trueness of intraoral scanners (IOSs) at anatomic locations within an intracoronal preparation are lacking.

Purpose: The purpose of this in vitro study was to evaluate the trueness of digital scans obtained by IOSs at the margin and intaglio surfaces of intracoronal preparations.

Material And Methods: Six IOSs (CEREC Omnicam, E4D, FastScan, iTero, TRIOS, Zfx IntraScan) were used to obtain digital scans of various intracoronal preparations.

Prosthetic outcomes and clinical performance of CAD-CAM monolithic zirconia versus porcelain-fused-to-metal implant crowns in the molar region: 1-year results of a RCT.

Objective: To investigate the clinical performance of monolithic zirconia implant crowns as compared to porcelain-fused-to-metal (PFM) implant crowns.

Materials And Methods: Seventy-six healthy patients received reduced diameter implants in the molar region. Following random allocation, either a monolithic zirconia crown (Mono-ZrO ) or a (PFM) was inserted.

Histologic Outcomes After Guided Bone Regeneration of Peri-implant Defects Comparing Individually Shaped Block Versus Particulate Bone Substitutes.

Peri-implant bone dehiscences were grafted either with deproteinized bovine bone mineral (DBBM) block or with particulate DBBM, both covered with a collagen membrane and stabilized with resorbable pins. After 6 months, 17 biopsy samples were included for histologic assessment. Block and particulate DBBM rendered successful tissue integration.

Trueness of digital intraoral impression in reproducing multiple implant position.

The aim of this study was to evaluate the trueness of 5 intraoral scanners (IOSs) for digital impression of simulated implant scan bodies in a partially edentulous model. A 3D printed partially edentulous mandible model made of Co-Cr with a total of 6 bilaterally positioned cylinders in the canine, second premolar, and second molar area served as the study model. Digital scans of the model were made with a reference scanner (steroSCAN neo) and 5 IOSs (CEREC Omnicam, CS3600, i500, iTero Element, and TRIOS 3) (n = 10).

Hard tissue changes after guided bone regeneration of peri-implant defects comparing block versus particulate bone substitutes: 6-month results of a randomized controlled clinical trial.

Objectives: To test whether block bone substitute used for guided bone regeneration (GBR) of peri-implant defects leads to different thickness of the augmented hard tissue than particulate bone substitute.

Material And Methods: In 24 patients, 24 two-piece dental implants were placed >4 months after tooth extraction. Following random allocation, 12 peri-implant bone dehiscences were grafted with an individually shaped block of deproteinized bovine-derived bone mineral (DBBM) and 12 bone dehiscences with particulate DBBM.

Load-bearing capacities of ultra-thin occlusal veneers bonded to dentin.

Objectives: To test whether the load-bearing capacity of occlusal veneers made of ceramic or hybrid materials bonded to dentin does differ from those of porcelain-fused-to metal or lithium disilicate glass ceramic crowns.

Material And Methods: In 80 human molars, occlusal tooth substance was removed so that the defects extended into dentin, simulating defects caused by attrition/erosion. Restorations at a standardized thickness of either 0.

Ultra-thin occlusal veneers bonded to enamel and made of ceramic or hybrid materials exhibit load-bearing capacities not different from conventional restorations.

Objectives: The objective of this study was to test whether or not the load-bearing capacity of occlusal veneers bonded to enamel and made of ceramic or hybrid materials does differ from those of porcelain-fused-to-metal or lithium disilicate glass ceramic crowns.

Material And Methods: In 80 human molars occlusal enamel was removed without extending into the dentin in order to mimic substance defects caused by attrition. The restorations were digitally designed at a standardized thickness of either 0.

Randomized controlled clinical trial of digital and conventional workflows for the fabrication of zirconia-ceramic fixed partial dentures. Part III: Marginal and internal fit.

Statement Of Problem: Trials comparing the overall performances of digital and conventional workflows in restorative dentistry are lacking.

Purpose: The purpose of the third part of this clinical study was to test whether the fit of zirconia 3-unit frameworks for fixed partial dentures fabricated with fully digital workflows differed from that of metal frameworks fabricated with the conventional workflow.

Material And Methods: In each of 10 participants, 4 fixed-partial-denture frameworks were fabricated for the same abutment teeth according to a randomly generated sequence.

Assessment of peri-implant defects at titanium and zirconium dioxide implants by means of periapical radiographs and cone beam computed tomography: An in-vitro examination.

Objective: To test the accuracy of measurement of interproximal peri-implant bone defects at titanium (Ti) and zirconium dioxide (ZrO ) implants by digital periapical radiography (PR) and cone beam computed tomography (CBCT).

Material And Methods: A total of 18 models, each containing one Ti and one ZrO implant, were cast in dental stone. Six models each were allocated to following defect groups: A-no peri-implant defect, B-1 mm width defect, C-1.

Clinical quality and efficiency of monolithic glass ceramic crowns in the posterior area: digital compared with conventional workflows.

Purpose: The aim of this clinical study was to test whether or not digital workflows for the fabrication of crowns render different clinical outcomes from the conventional pathway with respect to (1) crown quality, and (2) time efficiency.

Material And Methods: For each of the 10 patients in need of one tooth-supported crown, five monolithic crowns were produced out of lithium disilicate reinforced glass ceramic. Four different optical impression and associated computer-aided design/computer-aided manufacturing (CAD/CAM) systems were used for crown fabrication (digital workflows): (1) Lava C.

A Randomized Controlled Clinical Trial Comparing Conventional and Computer-Assisted Implant Planning and Placement in Partially Edentulous Patients. Part 1: Clinician-Related Outcome Measures.

The objectives of this study were to compare conventional and computer-assisted implant planning and placement (CAIPP) protocols regarding surgical planning predictability, intraoperative complications, and patient-centered outcomes. Partially edentulous patients (N = 73) were randomly allocated to one of three treatment groups: control (C, n = 26), with preoperative planning based on conventional radiography and freehand implant placement; and test 1 (T1, n = 24) and test 2 (T2, n = 23), with two different CAIPP protocols. The clinicians' predictions of the bony morphology, materials needed for surgery, and surgery duration were matched with intrasurgical findings using kappa tests.

Randomized controlled clinical trial of digital and conventional workflows for the fabrication of zirconia-ceramic posterior fixed partial dentures. Part II: Time efficiency of CAD-CAM versus conventional laboratory procedures.

Statement Of Problem: Clinical trials are needed to evaluate the digital and conventional fabrication technology for providing fixed partial dentures (FPDs).

Purpose: The purpose of the second part of this clinical study was to compare the laboratory production time for tooth-supported, 3-unit FPDs by means of computer-aided design and computer-aided manufacturing (CAD-CAM) systems and a conventional workflow. In addition, the quality of the 3-unit framework of each treatment group was evaluated clinically.

Randomized controlled clinical trial of digital and conventional workflows for the fabrication of zirconia-ceramic fixed partial dentures. Part I: Time efficiency of complete-arch digital scans versus conventional impressions.

Statement Of Problem: Clinical trials are needed to evaluate digital and conventional technologies for providing fixed partial dentures.

Purpose: The purpose of the first part of this clinical study was to test whether complete-arch digital scans were similar to or better than complete-arch conventional impressions regarding time efficiency and participant and clinician perceptions.

Material And Methods: Ten participants in need of a posterior tooth-supported 3-unit fixed partial denture were included.

Clinical Performance of Dental Implants Following Sinus Floor Augmentation: A Systematic Review and Meta-Analysis of Clinical Trials with at Least 3 Years of Follow-up.

Purpose: The purpose of this systematic review was to assess the survival of implants placed in augmented sinuses on a medium- to long-term basis, and identify factors affecting implant survival such as surgical technique, bone grafts, and timing of implant placement.

Materials And Methods: A literature search up to July 2016 was performed to identify prospective clinical studies on sinus floor augmentation in conjunction with implant placement with a minimum follow-up of 3 years. Meta-analytic methods were implemented to calculate implant survival rates and relative risks (RR) for failure and the effect of surgical technique, use of bone graft, graft type, use of membrane, mean residual bone height, and timing of implant insertion.

A strain gauge analysis comparing 4-unit veneered zirconium dioxide implant-borne fixed dental prosthesis on engaging and non-engaging abutments before and after torque application.

This study quantified the strain development after inserting implant-borne fixed dental prosthesis (FDP) to various implant-abutment joints. Two bone-level implants (∅ = 4.1 mm, RC, SLA 10 mm, Ti, Straumann) were inserted in polyurethane models (N = 3) in the area of tooth nos 44 and 47.

Single-Tooth Replacement Using Dental Implants Supporting All-Ceramic and Metal-Based Reconstructions: Results at 18 Months of Loading.

The aim of this study was to compare customized zirconia and titanium abutments with respect to survival rates and technical, biologic, and esthetic outcomes. A total of 28 patients with single implants were randomly assigned to 12 customized zirconia (test, AC) and 16 customized titanium (control, MC) abutments. Technical, biologic, and esthetic outcomes were assessed after a mean follow-up time of 18 months.

Clinical and histologic evaluation of different approaches to gain keratinized tissue prior to implant placement in fully edentulous patients.

Objectives: This work aimed to investigate the effectiveness and predictability of different treatment modalities for gain of keratinized tissue (KT) in fully edentulous jaws prior to dental implant placement: apically positioned flap (APF), APF plus xenogeneic collagen matrix (XCM), and APF plus free gingival graft (FGG).

Materials And Methods: In fully edentulous patients with insufficient zones of KT at the prospective implant positions, four treatment modalities were performed in the lower jaw: APF, XCM, FGG, and an untreated control group (control). APF and XCM were applied in the first molar positions, FGG and control in the canine positions.

Effect of Different Intraradicular Posts on the Color of the Buccal Gingiva at Teeth Restored with Zirconia Crowns.

The purpose of this study was to test whether prosthetic treatment with different intraradicular posts influences the color of the buccal gingiva at teeth restored with zirconia crowns. A total of 31 patients in need of a full-coverage single crown at an endodontically treated premolar, canine, or incisor in the maxilla or the mandible were included. The patients were randomly assigned to receive composite build-ups using titanium (Ti), zirconia (Zi), or glass-fiber (Gf) posts or a build-up using no post at all (NP).

Volumetric and linear changes at dental implants following grafting with volume-stable three-dimensional collagen matrices or autogenous connective tissue grafts: 6-month data.

Objectives: The objective of this study was to test whether or not soft tissue augmentation with a volume-stable collagen matrix (VCMX) leads to similar volume gain around dental implants compared to autogenous subepithelial connective tissue graft (SCTG).

Materials And Methods: In 12 adult beagle dogs, immediate implants were placed with simultaneous guided bone regeneration. After 25-45 weeks, soft tissue augmentation was randomly performed using VCMX, SCTG, or a sham-operated control.