THE RELATIONSHIP BETWEEN SERUM LEVEL OF MALONDIALDEHYDE AND PROGRESSION OF COLORECTAL CANCER.

- The purpose of the study was to assess the level of serum malondialdehyde (MDA) concentration and its association with the stage and histopathologic sizes of colorectal cancer (CRC). One hundred and two patients having undergone surgical treatment of CRC between January 2014 and December 2015 were included in this cross-sectional study. The patients were divided into four groups (stage I-IV) according to the TNM classification.

The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer.

Background: Tumor development and growth are driven in many cases by inflammatory cells, which can produce cytokines and other factors that can stimulate the development of the malignant process. The aim of this study was to evaluate interleukin-6 (IL-6), C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9), serum levels in patients with colorectal cancer (CRC), and their association with the stage of CRC.

Methods: IL-6, MMP-9, and CRP serum levels were measured in 75 patients with CRC just before surgical treatment, as well as in 20 healthy individuals as controls.

The association between the serum levels of matrix metalloproteinase 9 and colorectal cancer.

Aim To determine the serum levels of matrix metalloproteinase 9 (MMP-9) concentration and their association with the stage and histopathologic sizes of colorectal cancer (CRC). Methods One hundred and two patients with clinically diagnosed and histologically confirmed colorectal cancer ready for surgical treatment were included in the study. In each patient, preoperative peripheral venous blood samples were taken for determination of the concentration of MMP-9 using ELISA immunoassay test.

Evaluation of Risk Factors of Surgical Wound Dehiscence in Adults After Laparotomy.

Objectives: The percentage of patients with difficult and prolonged healing of the wound is still high, while the immediate complications such as wound dehiscence occurs in up to 3 % of all treated patients in abdominal surgery. The aim of study was to analyze the risk factors and comorbidities in the group patients undergoing laparotomy and associated with early postoperative wound dehiscence.

Methods: The retrospective study included all patients treated surgically at Clinic of General and Abdominal surgery, Clinical Center of the University of Sarajevo in the period from January 1, 2013 until January 1, 2016, with clinically verified surgical wound dehiscence.

Relationship Between Chronic Inflammation and the Stage and Histopathological Size of Colorectal Carcinoma.

Objectives: The association of inflammatory reactions with almost all types of cancer supports the concept that inflammation is a critical component of tumor progression. The present study aimed to evaluate the relationship of serum markers of chronic inflammation with the stage of and histopathological size of colorectal carcinoma (CRC).

Methods: This cross-sectional study included 90 patients of both sexes, mean age 66.

Evaluation of standardized and applied variables in predicting treatment outcomes of polytrauma patients.

Introduction: Polytrauma is defined as an injury where they are affected by at least two different organ systems or body, with at least one life-threatening injuries. Given the multilevel model care of polytrauma patients within KCUS are inevitable weaknesses in the management of this category of patients.

Objective: To determine the dynamics of existing procedures in treatment of polytrauma patients on admission to KCUS, and based on statistical analysis of variables applied to determine and define the factors that influence the final outcome of treatment, and determine their mutual relationship, which may result in eliminating the flaws in the approach to the problem.

[Broad indications for cephalic duodenopancreatoctomy].

Carcinoma pancreas takes fourth place based on the representation of carcinoma digestive methodology. Morbidity is about 16% of total morbidity carcinoma digestive system. Early discovery is relatively tough and resection in comparison to discovered cases amounts only 2-5% cases, and in the last period it increased from 10-15%.

[Early surgical complications after treatment of malignant diseases of the colon and rectum].

Operations malignity on the colon and rectum belong into a group of risky operational treatment, which has a high percentage of early postoperational complications in comparison to the other operational treatments in digestive surgery. To determine the precentage of the postoperational complication of the resectional treatment on the colon and rectum, obtained results compare with the experience of the other authors. Analysed 439 patients operated from malignity on the colon and rectum in five year period (1998-2002).

[Incidence of malignancies of the colon treated at the Clinic for Abdominal Surgery at the University Clinical Center in Sarajevo in the prewar (1987-1991) and postwar (1996-2000) period].

Malignant tumours are important health problems today. In most countries they are second cause of death in general population. In this work it was presented epidemiology of rectal cancer which are treated in Abdominal Surgery Department at University Clinical Center in Sarajevo of Bosnia and Herzegovina.