Publications by authors named "Gopireddy Venkata Subba Reddy"
Since 2018, N-nitrosamine impurities have become a widespread concern in the global regulatory landscape of pharmaceutical products. This concern arises due to their potential for contamination, toxicity, carcinogenicity, and mutagenicity and their presence in many active pharmaceutical ingredients, drug products, and other matrices. N-Nitrosamine impurities in humans can lead to severe chemical toxicity effects.
View Article and Find Full Text PDFEthyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates: Silica supported bismuth(III)triflate catalyzed synthesis and antioxidant activity.
Bioorg Chem
December 2022
Article Synopsis
- A novel class of compounds called ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates was synthesized using a one-pot Biginelli reaction involving aryl aldehydes, ethyl acetoacetate, and urea/thiourea with a green catalyst.
- The synthesized compounds showed high yields and short reaction times, were characterized using various spectroscopic methods, and 4i, 4j, 4h, and 4f were identified as having potential antioxidant properties through in vitro tests.
- Molecular docking studies revealed that these compounds interact strongly with a specific amino acid in a key enzyme, suggesting their
The foremost objective of the present study was to develop and validate a new LC-QTOF-MS/MS method for the identification and quantitative determination of 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine (DPP) genotoxic impurity through the derivatization process in ticagrelor active pharmaceutical ingredient (API). Owing to the low response of DPP at the specification level, DPP was converted to 4,6-dibenzylamino-5-nitro-2-(propylthio)pyrimidine (DPP derivative) by addition of benzyl amine, then analyzed using mass spectrometry with a time-of-flight analyzer, and good separation was accomplished under the experimental conditions described. The effective separation of DPP derivative was achieved using an Acquity UPLC BEH C reverse-phase column (100 × 4.
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