Publications by authors named "Gopinath Ramalingam"
Introduction: The coronavirus disease 2019 (COVID-19) is a viral infection characterized by respiratory and gastrointestinal symptoms. The causative agent of this infection is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The genomic study helps in understanding the pathogenesis, epidemiology, and the development of therapeutic and preventive strategies in the combat against COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- The research focuses on the virulence factors of Pseudomonas aeruginosa (P. aeruginosa), a pathogen that can cause serious infections, especially in the eyes, by releasing various harmful proteins and enzymes.
- It involved examining clinical isolates from both ocular (146 samples) and non-ocular (54 samples) sources to determine how common these virulence factors are and how they function.
- Key findings showed high prevalence of specific virulence genes in ocular isolates, suggesting a link between these factors and eye infections, thereby enhancing our understanding of P. aeruginosa's role in ocular disease.
According to the World Health Organization, infectious diseases, particularly those caused by multidrug-resistant bacteria (MDR), are projected to claim the lives of 15 million people by 2050. Septicemia carries a higher morbidity and mortality rate than infections caused by susceptible Pseudomonas aeruginosa, and MDR-mediated ocular infections can lead to impaired vision and blindness. To identify and develop a potential drug against MDR P.
View Article and Find Full Text PDFThe lack of a sensitive diagnostic tool for tuberculosis (TB) is the main reason for increasing cause of death in many developing countries. The routine diagnostic tests are either time-consuming or equivocal in terms of results. Hence, there is a need for quicker and accurate diagnostic tests.
View Article and Find Full Text PDFBackground: Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) kits have been reliably employed for the diagnosis of coronavirus disease 2019 (COVID-19) by the detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA since the beginning of the disease outbreak. In consideration of reliable diagnosis, apart from RT-PCR, the isothermal nucleic acid amplification-based point-of-care automated kits have also been tagged as a simpler and rapid alternative to the conventional techniques. Currently, the availability of a better diagnostic method for COVID-19 when compared to RT-PCR is nil.
View Article and Find Full Text PDF