The impact of oral multinutrient supplementation on in vitro fertilisation or intracytoplasmic sperm injection outcomes: A prospective controlled study.

Introduction: Micronutrients influence female fertility, thus adequate levels are important for oocyte quality, maturation, fertilisation and implantation. This study prospectively evaluated the impact of oral multinutrient supplementation on fertility outcomes in In vitro fertilisation or Intracytoplasmic sperm injection (IVF/ICSI).

Materials And Methods: This was a pilot study of N=50 women, who were planning for IVF treatment in University Malaya Medical Centre, Kuala Lumpur, Malaysia from July to December 2023.

Clinicodemographic profile, management, and treatment outcomes in advanced retinoblastoma at a tertiary care center in North India.

Purpose: The study was undertaken to look into the clinicodemographic profile, management, and clinical outcomes of advanced retinoblastoma at a tertiary care center.

Methods: A prospective cohort study was conducted from Jan 2019 to Dec 2022. Forty-two patients of intraocular advanced retinoblastoma were assessed.

A review on extraction of polysaccharides from crustacean wastes and their environmental applications.

Disposal of biodegradable waste of seashells leads to an environmental imbalance. A tremendous amount of wastes produced from flourishing shell fish industries while preparing crustaceans for human consumption can be directed towards proper utilization. The review of the present study focuses on these polysaccharides from crustaceans and a few important industrial applications.

A multi-pronged approach to source attribution and apportionment of heavy metals in urban rivers.

Heavy metal (HM) contamination of water bodies is caused by both first generation (industries) and second generation (distributed sources, domestic sewage, sediments) sources. We applied a multi-pronged approach to quantify the contribution of first and second generation sources to the HM load in a stream located in an industrialised catchment. We found that, despite strict regulation, first generation sources contributed significantly to the HM load (60%-80%), showing the ineffectiveness of current regulation.

To Study the Incidence of Diabetic Retinopathy in Different Stages of Diabetic Nephropathy in Type 2 Diabetes Mellitus.

Unlabelled: India being a developing country and undergoing socioeconomic growth on fast pace is at a higher risk of catering diabetic population owing to the unhealthy lifestyle with a significant fraction belonging to the urban population. According to IDF, estimated population with diabetes in India as in 2019 is 77.0056 million which accounts for around 10.

To Study the Platelet Indices as a Predictor of Microvascular Complications in Type 2 Diabetes Mellitus.

Unlabelled: Diabetes mellitus, a prothrombotic state with enhanced platelet reactivity, presents with altered platelets indices. Increased platelet activation has been suggested to be involved in the pathogenesis of vascular complications of T2DM.

Material: This was a prospective observational study carried from December 2019 to June 2021, to evaluate the alteration in Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT) and Platelet Large Cells Ratio (P-LCR) among 150 patients with T2DM who were admitted in In Patient Department in Department of General Medicine in a tertiary care centre after taking their verbal consent.

Primary retroperitoneal extraovarian granulosa cell tumor.

Extraovarian granulosa cell tumors (GCTs) develop from ectopic gonadal tissue situated along the embryonal route of the genital ridge. Primary retroperitoneal tumors are extremely rare, with an incidence of 02% -06% and 80-85% probability of malignancy. Only eight such case reports have been published previously.

Ethanolic extract of Pyrus pashia buch ham ex. D. Don (Kainth): A bioaccessible source of polyphenols with anti-inflammatory activity in vitro and in vivo.

Ethnopharmacological Relevance: Pyrus pashia Buch ham ex. D. Don (Kainth) fruit from the Himalayan region is traditionally consumed by native people in the form of decoctions for various clinical conditions including inflammatory diseases.

Fractionation, characterization, and economic evaluation of alkali lignin from saw industry waste.

The present work was focused on the investigation of lignin isolation from saw industry biomass (sawdust (SD)) using alkali solution, and to perform economic analysis for 2000 kg/batch hypothetical plant using techno-economic analysis. The isolated lignin was fractionated using organic solvent to obtain purified lignin. FTIR and H NMR analysis were performed to examine the structural characteristics of lignin.

Lipid bioproduction from delignified native grass (Cyperus distans) hydrolysate by Yarrowia lipolytica.

In the present study, native grass (Cyperus distans) was utilized for the production of lipid using Yarrowia lipolytica MTCC 9519. Initially, pretreatment methods using hydrothermal and alkaline delignification were performed to obtain cellulose rich liquid fractions. Delignified native grass biomass was enzymatically hydrolyzed to convert non fermentable sugars in to fermentable sugars.

α-lipoic acid protects testis and epididymis against linuron-induced oxidative toxicity in adult rats.

Linuron is well known for its antiandrogenic property. However, the effects of linuron on testicular and epididymal pro- and antioxidant status are not well defined. On the other hand, α-lipoic acid is well known as universal antioxidant.

Enhanced malic acid production using Aspergillus niger coupled with in situ product recovery.

In the present investigation, recovery of malic acid from the fermentation broth was performed by using in situ reactive extraction method employing different combination of amine and solvent systems. Totally six solvent mixtures were tested for toxicity on Aspergillus niger PJR1. Further, effect of solvent mixture concentration on separation of malic acid was investigated.

Out-of-Field Dose Calculation by a Commercial Treatment Planning System and Comparison by Monte Carlo Simulation for Varian TrueBeam.

Purpose: The calculation accuracy of treatment planning systems (TPSs) drops drastically when the points outside the field edges are considered. The real accuracy of a TPS and linear accelerator (linac) combination for regions outside the field edge is a subject which demands more study. In this study, the accuracy of out-of-field dose calculated by a TPS, used with a TrueBeam (TB) linac, is quantified.

A review on role of ATM gene in hereditary transfer of colorectal cancer.

Colorectal cancer found to be the most commonly occurring cancer worldwide which can be prevented by screening and its curable if diagnosed early. Lynch syndrome/HNPCC being an autosomal genetic disease and propensity in forming colorectal cancer is inherited wherein genomic instabilities and epigenetic changes are being the characteristic forms in hereditary cancers. It is very important to determine the polymorphism in several DNA repairing genes such as ATM, RAD51, XRCC2, XRCC3 and XRCC9 to study the risk exploring both the prognosis and the developing of colorectal cancer.

Concise Review on Clinical Applications of Conditioned Medium Derived from Human Umbilical Cord-Mesenchymal Stem Cells (UC-MSCs).

In recent years, mesenchymal stem cells have provoked much attentiveness in the field of regenerative medicine because of their differentiation potential and the capability to facilitate tissue repair via the emancipation of biologically active molecules. They have gained interest because of their distinctive curative properties. Mesenchymal stem cells are isolated from the Wharton's jelly part of umbilical cord possessing higher proliferation capacity, immunomodulatory activity, plasticity, as well as self-renewal capacity than the mesenchymal stem cells from various origins, and it is considered to be the best resource for allogeneic transplantation.

Results of Endovascular-First Approach for Treatment of Scalp Arteriovenous Malformations and the Effect of Simplified Angiographic Classification in Therapeutic Decision-Making and Outcomes.

Background: Scalp arteriovenous malformation (SAVM) is primarily treated by surgery and reports on endovascular treatment are scarce. We report the results of an endovascular-first approach in the treatment of SAVM. We also have proposed a simple dichotomized classification using the angiographically determined morphology findings and discussed its effect on therapeutic decision-making and outcomes.

Role of Hippo Pathway Effector Tafazzin Protein in Maintaining Stemness of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSC).

Tafazzin (TAZ) protein has been upregulated in various types of human cancers, although the basis for elevation is uncertain, it has been made definite that the effect of mutation in the hippo pathway, particularly when it is switched off, considerably activates tafazzin transcriptionally and thus this results in tissue or tumor overgrowth. Recent perceptions into the activity of tafazzin, have ascribed to it, a role as stem cell factor in mouse mesenchymal and as well as in neural stem cells. Being a downstream molecule in Hippo signalling, phosphorylation or dephosphorylation of tafazzin gene regulates its transcriptional activity and the stemness of mesenchymal stem cells.

Sustainable power generation from sewage and energy recovery from wastewater with variable resistance using microbial fuel cell.

Wastewater from sewage sources contribute significantly to water pollution from domestic waste; one way to recover energy from these sources while at the same time, treating the water is possible using Microbial Fuel Cell. In this work, a two chambered microbial fuel cell was designed and fabricated with carbon cloth electrodes and Nafion-117 membrane, having Platinum as the catalyst. Wastewater from an organic load of 820 ± 30 mg/l reduced to around 170 mg/l, with the change in pH from 7.

Evaluation of potential anti-cancer activity of cationic liposomal nanoformulated in colon cancer cells.

Research dealing with early diagnosis and efficient treatment in colon cancer to improve patient's survival is still under investigation. Chemotherapeutic agent result in high systemic toxicity due to their non-specific actions on DNA repair and/or cell replication. Traditional medicine such as (LC) has been claimed to have therapeutic potentials against cancer.

Health hazards of nanoparticles: understanding the toxicity mechanism of nanosized ZnO in cosmetic products.

In recent years, nanoparticles are being used extensively in personal healthcare products such as cosmetics, sunscreens, soaps, and shampoos. Particularly, metal oxide nanoparticles are gaining competence as key industrial constituents, progressing toward a remarkable rise in their applications. Zinc oxide and titanium oxide nanoparticles are the most commonly employed metal oxide nanoparticles in sunscreens, ointments, foot care, and over the counter topical products.