Hemoglobin targeting potential of aminocarb pesticide: Investigation into dynamics, conformational stability, and energetics in solvent environment.

Aminocarb (AMC), a carbamate pesticide, due to its prevalent usage exhibits increased accumulation in the environment affecting both insects and humans. It enters the human body via food grains and be transported through bloodstream. AMC's chemical structure, containing specific molecular frameworks and functional groups, enables it to bind with proteins like albumin and hemoglobin.

NHEJ is promoted by the phosphorylation and phosphatase activity of PTEN via regulation of DNA-PKcs.

DNA double-strand breaks (DSBs) are considered one of the most harmful forms of DNA damage. These DSBs are repaired through non-homologous end joining (NHEJ) and homologous recombination (HR) pathways and defects in these processes can lead to genomic instability and promote tumorigenesis. Phosphatase and Tensin homolog (PTEN) are crucial in HR repair.

Insights on the comparative affinity of ribonucleic acids with plant-based beta carboline alkaloid, harmine: Spectroscopic, calorimetric and computational evaluation.

Small molecules as ligands target multifunctional ribonucleic acids (RNA) for therapeutic engagement. This study explores how the anticancer DNA intercalator harmine interacts various motifs of RNAs, including the single-stranded A-form poly (rA), the clover leaf tRNA, and the double-stranded A-form poly (rC)-poly (rG). Harmine showed the affinity to the polynucleotides in the order, poly (rA) > tRNA > poly (rC)·poly (rG).

Improving load frequency controller tuning with rat swarm optimization and porpoising feature detection for enhanced power system stability.

Load frequency control (LFC) plays a critical role in ensuring the reliable and stable operation of power plants and maintaining a quality power supply to consumers. In control engineering, an oscillatory behavior exhibited by a system in response to control actions is referred to as "Porpoising". This article focused on investigating the causes of the porpoising phenomenon in the context of LFC.

Biology of Variola Virus.

Variola virus is an anthroponotic agent that belongs to the orthopoxvirus family. It is an etiological agent of smallpox, an ancient disease that caused massive mortality of human populations. Twentieth century has witnessed the death of about 300 million people due to the unavailability of an effective vaccine.

Performance and robustness analysis of V-Tiger PID controller for automatic voltage regulator.

This paper presents a comprehensive study on the implementation and analysis of PID controllers in an automated voltage regulator (AVR) system. A novel tuning technique, Virtual Time response-based iterative gain evaluation and re-design (V-Tiger), is introduced to iteratively adjust PID gains for optimal control performance. The study begins with the development of a mathematical model for the AVR system and initialization of PID gains using the Pessen Integral Rule.

Biophysical and structural characterization of tetramethrin serum protein complex and its toxicological implications.

Tetramethrin (TMT) is a commonly used insecticide and has a carcinogenic and neurodegenerative effect on humans. The binding mechanism and toxicological implications of TMT to human serum albumin (HSA) were examined in this study employing a combination of biophysical and computational methods indicating moderate binding affinity and potential hepato and renal toxicity. Fluorescence quenching experiments showed that TMT binds to HSA with a moderate affinity, and the binding process was spontaneous and predominantly enthalpy-driven.

Structure and energetics of serum protein complex of tea adulterant dye Bismarck brown Y using experimental and computational methods.

Tea, a widely consumed aromatic beverage, is often adulterated with dyes such as Bismarck brown Y (C.I. 21000) (BBY), Prussian blue, and Plumbago, which pose potential health risks.

Acoustic resonance therapy is safe and effective for the treatment of nasal congestion in rhinitis: A randomized sham-controlled trial.

Background: Acoustic resonance therapy (ART) is a novel vibrational treatment that delivers patient-specific resonant frequency acoustic energy to the sinonasal cavities. In a pilot study, ART was effective for the acute treatment of nasal congestion. We conducted a sham-controlled randomized trial to validate the efficacy of ART when administered daily for 2 weeks.

Cyanobacterial compound Tolyporphine K as an inhibitor of Apo-PBP (penicillin-binding protein) in and its ADME assessment.

Antibiotic-resistant Acinetobacter baumannii, is a common pathogen found in hospital settings and has become nosocomial due to its high infection-causing tendency amongst ICU patients. The present study explores the cyanocompoundswhich were capable to inhibit the Penicillin Binding Protein of A. baumannii through molecular docking, ADMET, and molecular dynamicssimulation strategy.

Binding studies of sertraline hydrochloride with CT-DNA using experimental and computational techniques.

Sertraline Hydrochloride (STH) is an antidepressant drug that belongs to the selective serotonin reuptake inhibitor family (SSRIs), which inhibits serotonin uptake in presynaptic nerve fibers. The use of these medications without a legitimate prescription might result in adverse effects, and in rare circumstances, death. The interaction mechanism and binding mode of STH with duplex DNA were extensively investigated using spectroscopic and modeling techniques at different temperatures.

A comparative study on DNA and protein binding properties of thymol and thymoquinone.

Two phytochemicals, thymol and thymoquinone obtained from () and seed, respectively. Both the phytochemicals show several biochemical activities like anticancer, antimicrobial etc. In this paper, we studied the affinities of thymol and thymoquinone towards calf thymus DNA (CT-DNA) and protein (bovine serum albumin).

Epstein-Barr virus infection controls the concentration of the intracellular antioxidant glutathione by upregulation of the glutamate transporter EAAT3 in tumor cells.

Epstein-Barr virus or human herpesvirus 4 (EBV/HHV-4) is an omnipresent oncovirus etiologically associated with various B-cell lymphomas and epithelial cancers. The malignant transformation associated with the persistent expression of viral proteins often deregulates the host cellular machinery and EBV infection is coupled to elevated levels of reactive oxygen species. Here, we investigated the role that the glutamate transporter EAAT3 plays in regulating the antioxidant system as a protective mechanism of EBV-infected cells against the virus-induced oxidative stress.

Thermodynamic and structural profiles of multi-target binding of vinblastine in solution.

Structural information about drug-receptor interactions is paramount in drug discovery and subsequent optimization processes. Drugs can bind to multiple potential targets as they contain common chemical entities in their structures. Understanding the details of such interactions offer possibilities for repurposing and developing potent inhibitors of disease pathways.

Structural aspects of SARS-CoV-2 mutations: Implications to plausible infectivity with ACE-2 using computational modeling approach.

Some of the SARS-CoV-2 variants are said to be more infectious than the previous others and are causing panic around the globe. Cases related to Delta plus (δ+) and omicron (ο) variants are on the rise worldwide. This sudden surge warrants an investigation into the reasons for its binding with ACE-2.

Structural aspects of formetanate hydrochloride binding with human serum albumin using spectroscopic and molecular modeling techniques.

Formetanate Hydrochloride (FMT), a highly potent chemical, acts as an insecticide, acaricide, and miticide to protect various fruits and vegetables. The widespread use elevates concern about its presence in the ecosystem, impact upon human health via interaction with biological receptors. Spectroscopic and molecular modeling techniques at different temperatures were used to investigate the binding of FMT with Human serum albumin (HSA) at the molecular level.

High-performance electrochemical sensing of hazardous pesticide Paraoxon using BiVO nano dendrites equipped catalytic strips.

Paraoxon is one of the pesticide that can induce toxicity to nervous system of living organisms. In this work, we focused on synthesizing the catalyst Bismuth Vanadate with the properties that can sense the presence of organophosphorus compounds and characterized them with various characterization methods. The structural studies done by XRD, UV spectroscopy and FTIR spectroscopy.

SARS-Coronavirus 2, A Metabolic Reprogrammer: A Review in the Context of the Possible Therapeutic Strategies.

Novel coronavirus, SARS-CoV-2, is advancing at a staggering pace to devastate the health care system and foster concerns over public health. In contrast to the past outbreaks, coronaviruses are not clinging themselves as a strict respiratory virus. Rather, becoming a multifaceted virus, it affects multiple organs by interrupting a number of metabolic pathways leading to significant rates of morbidity and mortality.

Amperometric determination of ecotoxic N-methyl-p-aminophenol sulfate in photographic solution and river water samples based on graphene oxide/CeNbO nanocomposite catalyst.

The electronic conductivity of the metal oxides is generally increased by hybridization of highly conductive carbon supportive materials. In this present work, we have demonstrated a novel one-pot preparation of cerium niobate (CeNbO) nanoparticles embedded with graphene oxide (GO/CeNbO) composite, for ultrasensitive detection of the photographic developing agent, metol (MTL). The as-prepared GO/CeNbO was analyzed by various characterization techniques.

Tailoring of bismuth vanadate impregnated on molybdenum/graphene oxide sheets for sensitive detection of environmental pollutants 2, 4, 6 trichlorophenol.

In the present work, we reported a one pot simple colloidal-gel synthesis of molybdenum bismuth vanadate (MoBiVO). The charge transfer property of MoBiVO was improved by developing a composite with graphene oxide (GO) through sonochemical technique. The optical and morphological analysis revealed that successful formation of GO-MoBiVO composite without any other filth.

Electrochemical sensing base for hazardous herbicide aclonifen using gadolinium niobate (GdNbO) nanoparticles-actual river water and soil sample analysis.

The present work scrutinized the voltammetric analysis of hazardous herbicide aclonifen (ACF) in actual soil and river water samples utilizing the electrochemical method. The electrochemical sensing device was fabricated for the determination of ACF using gadolinium niobate (GdNbO) nanoparticles modified glassy carbon electrode (GCE). The novel GdNbO sensing material was prepared via a simple co-precipitation method.

Unicentric Castleman's Disease as a Localized Retroperitoneal Mass: A Case Report and Review of Literature.

Castleman's disease (CD) is a rare disorder characterized by proliferation of the lymphoid tissue. Clinically, it presents in two forms either a unicentric (UC) or multicentric. Mediastinum is the most common location.

Spindle cell sarcoma of thyroid: a case report.

Spindle cell sarcoma of thyroid represents a rare entity that may arise primarily from thyroid gland as a variant of thyroid cancer or as metastatic. We report a case of 60 year old man who presented with 2 months history of rapidly growing thyroid enlargement with no obstructive features and preliminary diagnosis of spindle cell lesion of thyroid was made with cytological examination. He underwent total thyroidectomy and histological examination revealed spindle cell sarcoma of thyroid confirmed by immunohistochemical reactions.