Publications by authors named "Gopi K Sirineni"

Adrenal incidentalomas occur in 5% of adults and can produce autonomous cortisol secretion that increases the risk of metabolic syndrome and cardiovascular disease. The objective of our study was to evaluate the relationship between adrenal nodule size measured on CT and autonomous cortisol secretion. In a prospective study of 73 patients 22-87 years old with incidentalomas, unilateral in 52 patients and bilateral in 21 patients, we measured maximum nodule diameter on CT and serum cortisol levels at 8:00 am, 60 minutes after the adrenocorticotropic hormone stimulation test, and after the dexamethasone suppression test.

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Background: We evaluated the incremental diagnostic value of fusion images of coronary computed tomography angiography (CTA) and myocardial perfusion imaging (MPI) over MPI alone or MPI and CTA side-by-side to identify obstructive coronary artery disease (CAD > 50% stenosis) using invasive coronary angiography (ICA) as the gold standard.

Methods: 50 subjects (36 men; 56 +/- 11 years old) underwent rest-stress MPI and CTA within 12-26 days of each other. CTAs were performed with multi-detector CT-scanners (31 on 64-slice; and 19 on 16-slice).

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Coronary artery calcium (CAC) accumulation, a marker of atherosclerosis burden, differs significantly among patients of different ethnicities. It has been proposed that CAC scores can be used to assess the number of life years lost or gained by an individual with a given amount of coronary artery calcium. Therefore, we sought to develop a method to calculate the coronary age of an individual based on the extent of CAC in this subject compared to that of individuals of the same race, age and sex.

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Methods of noninvasive evaluation of coronary artery disease-including multidetector row computed tomography, electron beam computed tomography, magnetic resonance imaging, and nuclear studies (single photon emission computed tomography, positron emission tomography)-are reviewed.

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Cardiac computed tomography (CT) scans can produce enormous datasets (>3,000 images), making traditional axial image interpretation un-workable. Previously existing and new techniques including multiplanar reformats, volume rendering, maximum intensity projections, curved multiplanar reformats, and "4D" (time-resolved) methods have all been used to increase diagnostic accuracy and reduce interpretation times. The methods and applications of these techniques to cardiac anatomy will be reviewed and discussed with an eye toward practical film interpretation.

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Introduction: To evaluate effect of different kVp, reconstruction kernels and contrast concentrations on stent luminal diameter measurements and luminal contrast attenuation values.

Methods: Two metallic coronary stents (2.75 mm and 3.

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