Rapid and automated design of two-component protein nanomaterials using ProteinMPNN.

The design of protein-protein interfaces using physics-based design methods such as Rosetta requires substantial computational resources and manual refinement by expert structural biologists. Deep learning methods promise to simplify protein-protein interface design and enable its application to a wide variety of problems by researchers from various scientific disciplines. Here, we test the ability of a deep learning method for protein sequence design, ProteinMPNN, to design two-component tetrahedral protein nanomaterials and benchmark its performance against Rosetta.

Police Decisions in a Rape Scenario: The Effect of Trauma Response, Forensic Evidence, Stranger-Perpetrators, and Rape Mythology.

This study examined the direct effect of "classic rape" characteristics, and how they were moderated by rape myth endorsement, on the likelihood of arrest, perceived district attorney charge acceptance, and perceived suspect conviction using a formal rape disclosure among a sample of 468 police participants from a sizeable municipal law enforcement agency in one of the fifth largest and most diverse U.S. cities.

Rapid and automated design of two-component protein nanomaterials using ProteinMPNN.

The design of novel protein-protein interfaces using physics-based design methods such as Rosetta requires substantial computational resources and manual refinement by expert structural biologists. A new generation of deep learning methods promises to simplify protein-protein interface design and enable its application to a wide variety of problems by researchers from various scientific disciplines. Here we test the ability of a deep learning method for protein sequence design, ProteinMPNN, to design two-component tetrahedral protein nanomaterials and benchmark its performance against Rosetta.

Academic Training in Oral and Maxillofacial Surgery - when and how to enter the pathway.

Entering into surgical academia can seem a daunting prospect for an oral and maxillofacial surgery (OMFS) trainee. However, the streamlining of academic training by the NIHR to create the integrated academic training (IAT) pathway has simplified academic training and more clearly defined academic positions and entry points for trainees. In this article we review the current NIHR IAT pathway and the various grades and entry points available to OMF surgeons, both pre- and post-doctoral.

Police Officers' Attributions of Victim Culpability in Scenarios of Same-Sex Intimate Partner Violence.

Intimate partner violence (IPV) has garnered the attention of scholars, policymakers, and social justice actors for several decades. Shortcomings in police response to IPV may be related to police attributions of victim culpability. A dearth of research has assessed police officers' assignment of blame, responsibility, and causality directed toward IPV victims, particularly those who identify as LGBTQ+.

Accuracy and cost effectiveness of a waferless osteotomy approach, using patient specific guides and plates in orthognathic surgery: a systematic review.

The aim of this systematic review is to evaluate the accuracy of waferless osteotomy procedures in orthognathic surgery with a secondary aim to determine the cost-effectiveness of the procedure. A literature search was conducted on the databases PubMed and Scopus, with PRISMA guidelines followed. An initial yield of 4149 articles were identified, ten of which met the desired inclusion criteria.

Surgical tumour margins and their significance in oral squamous cell carcinoma.

There are many prognostic indicators used to predict tumour recurrence and overall prognosis in oral squamous cell carcinoma (OSCC). Most of these biological factors cannot be directly influenced by clinicians managing these heterogeneous group of tumours. Excision margins can potentially be increased at the time of surgery by including more normal tissue than the commonly accepted 1 cm resection distance from the macroscopic tumour edge.

Blending Linear and Cyclic Block Copolymers to Manipulate Nanolithographic Feature Dimensions.

Block copolymers (BCPs) consist of two or more covalently bound chemically distinct homopolymer blocks. These macromolecules have emerging applications in photonics, membrane separations, and nanolithography stemming from their self-assembly into regular nanoscale structures. Theory suggests that cyclic BCPs should form features up to 40% smaller than their linear analogs while also exhibiting superior thin-film stability and assembly dynamics.

Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex.

The recollection of environmental cues associated with threat or reward allows animals to select the most appropriate behavioral responses. Neurons in the prelimbic (PL) cortex respond to both threat- and reward-associated cues. However, it remains unknown whether PL regulates threat-avoidance vs.

Police Response to Latina Immigrant Intimate Partner Violence Victims: A Qualitative Analysis.

While an increasing body of literature has assessed police response to intimate partner violence (IPV), a dearth of this research has examined police decision-making with formal reports of IPV among Latina immigrants. Using a LatCrit theoretical framework, the current study addressed this substantive gap through the systematic methods of the grounded theory approach to assess a sample of 36 police case files drawn from an agency located in one of the fifth most populous and diverse US cities. Results from the current study identified five themes related to shortcomings in police response to Latina immigrant IPV victims.

Printed titanium implants in UK craniomaxillofacial surgery. Part I: access to digital planning and perceived scope for use in common procedures.

This first part of a two-part study examines perceived applications for and barriers to using printed titanium in light of current caseloads, funding pathways, and use of digital planning. It aims to demonstrate the scope for printed titanium in modern practice and to guide industry about the needs of UK surgeons. A cross-sectional study over 14 weeks was performed electronically with support from the British Association of Oral and Maxillofacial Surgeons (BAOMS) and a national trainee-led recruitment team.

Printed titanium implants in UK craniomaxillofacial surgery. Part II: perceived performance (outcomes, logistics, and costs).

This second part explores perceptions and understanding of clinical performance, turnaround, and costs for printed titanium implants or plates in common procedures, evaluating both 'in-house' and 'outsourced' CAD-CAM pathways. A cross-sectional study, supported by the British Association of Oral and Maxillofacial Surgeons (BAOMS) and a national trainee-led recruitment team, was conducted over 14 weeks. A total of 132 participants took part (demographic data is reported in Part I).

UNICORN Babies: Understanding Circulating and Cerebral Creatine Levels of the Preterm Infant. An Observational Study Protocol.

Creatine is an essential metabolite for brain function, with a fundamental role in cellular (ATP) energy homeostasis. It is hypothesized that preterm infants will become creatine deplete in the early postnatal period, due to premature delivery from a maternal source of creatine and a limited supply of creatine in newborn nutrition. This potential alteration to brain metabolism may contribute to, or compound, poor neurological outcomes in this high-risk population.

Crime Victim Service Providers' Needs and Barriers: Rurality and "High Need".

The crime victims' rights movement has led to the development of advocacy, rights, and services for crime victims. A growing body of research has examined victim service provision using victim/client samples and complementary research has utilized service provider samples. The latter have focused on crime victim service providers' (VSPs) perceptions regarding clients' needs and barriers, as well as perceptions of service provision, needs, and barriers pertaining to their agency's operations.

Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF).

Left ventricular ejection fraction (LVEF) is an important prognostic indicator of cardiovascular outcomes. It is used clinically to determine the indication for several therapeutic interventions. LVEF is most commonly derived using in-line tools and some manual assessment by cardiologists from standardized echocardiographic views.

Help-Seeking Behaviors of Intimate Partner Violence Victims: A Cross-National Analysis in Developing Nations.

There is a dearth of research on help-seeking behaviors of intimate partner violence (IPV) victims, especially within developing nations. The current study uses the nationally representative population-based Demographic and Health Surveys (DHS) of 31 nations to address this gap in the literature. Specifically, the study (a) assesses the extent to which IPV victims sought help in developing nations, (b) investigates from whom IPV victims sought help, and (c) evaluates individual and national factors that influence the likelihood of help seeking among IPV victims in developing nations.

The Rural/Urban Divide: Examining Different Types of Assault Through a Social Disorganization Lens.

Most studies of social disorganization theory focus on urban communities. In addition, these studies largely ignore more intimate crimes, such as intimate partner violence. Yet, results from extant studies are often generalized to explain all types of crime in all types of communities, thus potentially ignoring the dynamics surrounding intimate crimes and rurality.