Autoimmune pancreatitis: an underdiagnosed autoimmune disease with clinical, imaging and serological features.

Since Sarles et al. [Sarles H, Sarles JC, Muratore R, Guien C. Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease? Am J Dig Dis 1961; 6: 688-698.

Hereditary pancreatitis: clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSS1) in six Spanish families.

Context: Hereditary pancreatitis is an autosomal dominant disease which is caused by mutations in the PRSS1 gene.

Objective: The aim of our study was to describe the penetrance and phenotype-genotype correlations of the c.346C>T (p.

Pancreatic fibrosis in rats and its response to antioxidant treatment.

Context: Oxidative stress plays a role in the development of pancreatic fibrosis.

Objectives: In the present study, we hypothesized that the administration of an antioxidant complex could ameliorate cerulein and cyclosporin A pancreatic fibrosis, assessed by changes in oxidative stress and a histopathological study in an experimental rat model.

Animals: Four groups of ten rats each.

[Screening of celiac disease in first-degree relatives].

Background And Objective: Our aim was to analyze the prevalence of celiac disease (CD) in first-degree relatives of patients diagnosed with this disorder in Cantabria (Northern Spain).

Subjects And Method: A questionnaire was administered and a complete biologic study was performed in 184 relatives. When serum CD-related antibodies were detected, relatives were asked to undergo a jejunal biopsy to confirm the diagnosis.