Publications by authors named "Gonzalo Valenzuela"
Unlabelled: Extubation failure (EF) after cardiac surgery is associated with poorer outcomes. Approximately 50% of children with Down syndrome (DS) have congenital heart disease. Our primary aim was to describe the frequency of EF and identify risk factors for its occurrence in a population of patients with DS after cardiac surgery.
View Article and Find Full Text PDFBackground: Obesity increases the severity of coronavirus disease 2019 illness in adults. The role of obesity in short-term complications and post-acute sequelae in children is not well defined.
Objective: To evaluate the relationship between obesity and short-term complications and post-acute sequelae of SARS-CoV-2 infection in hospitalized paediatric patients.
Background: A major challenge of the SARS-CoV-2 pandemic is to better define "protective thresholds" to guide the global response. We aimed to characterize the longitudinal dynamics of the antibody responses in naturally infected individuals in Chile and compared them to humoral responses induced after immunization with CoronaVac-based on an inactivated whole virus -or the BNT162b2- based on mRNA-vaccines. We also contrasted them with the respective effectiveness and efficacy data available for both vaccines.
View Article and Find Full Text PDFObjectives: To: 1. Describe the frequency of viral RNA detection in stools in a cohort of patients infected with SARS-CoV-2, and 2. Perform a systematic review to assess the clearance time in stools of SARS-CoV-2.
View Article and Find Full Text PDFArticle Synopsis
- Patients previously infected with SARS-CoV-2 develop strong neutralizing antibody (nAb) responses, peaking around 3-4 weeks after symptom onset, and these responses can last for up to 12 months.
- Vaccination can significantly boost nAb levels in individuals who were previously infected, with two doses of CoronaVac or one dose of BNT162b2 strengthening the immune response, although some groups, like obese individuals, may not respond as well.
- Naïve individuals receiving the same vaccine doses achieve nAb levels comparable to those of recovered patients months after natural infection, highlighting the need for two doses of CoronaVac for effective immunity in both groups.
Background: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome virus (SARS-CoV-2) is challenging global public health, due to an increasing demand for testing and the shortage of diagnostic supplies. Nasopharyngeal swab (NPS) is considered the optimal sample for SARS-CoV2 diagnosis and sputum (SPT) has been proposed as an economic alternative. However, the temporal concordance of diagnosis in NPS and SPT has not been addressed.
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