Publications by authors named "Gonzalo J Lopez"
Aims: The aim of this study was to study changes in coronary microcirculation status during and after several cycles of anthracycline treatment.
Methods And Results: Large-white male pigs (n=40) were included in different experimental protocols (ExPr.) according to anthracycline cumulative exposure [0.
Aims: Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC.
View Article and Find Full Text PDFArticle Synopsis
- Nonrevascularizable coronary artery disease often leads to hibernating myocardium, contributing to heart failure, but treatment options are limited.
- A new large animal model using Yucatan minipigs mimics the clinical features of hibernating myocardium with surgical obstruction of the LAD artery and extensive imaging to monitor heart condition.
- The model shows high rates of left ventricular systolic dysfunction and viability in at-risk heart tissue, making it a promising tool for testing new therapies before clinical trials for coronary artery disease and ischemic heart failure.
Aims: To assess whether R2* is more accurate than T2* for the detection of intramyocardial haemorrhage (IMH) and to evaluate whether T2' (or R2') is less affected by oedema than T2* (R2*), and thus more suitable for the accurate identification of post-myocardial infarction (MI) IMH.
Methods And Results: Reperfused anterior MI was performed in 20 pigs, which were sacrificed at 120 min, 24 h, 4 days, and 7 days. At each time point, cardiac magnetic resonance (CMR) T2- and T2*-mapping scans were recorded, and myocardial tissue samples were collected to quantify IMH and myocardial water content.
Background: Anthracycline-induced cardiotoxicity is a major clinical problem, and early cardiotoxicity markers are needed.
Objectives: The purpose of this study was to identify early doxorubicin-induced cardiotoxicity by serial multiparametric cardiac magnetic resonance (CMR) and its pathological correlates in a large animal model.
Methods: Twenty pigs were included.
Background: Left atrial (LA) remodeling after an acute myocardial infarction (MI) is poorly characterized regarding its determinants or its effect on ischemic mitral regurgitation (MR) development.
Objectives: The purpose of this study was: 1) to compare LA structural remodeling in experimental MI swine models recapitulating the effects of left ventricular (LV) dysfunction, ischemic MR, and left atrial infarction (LAI); and 2) to analyze how LA remodeling influences ischemic MR development.
Methods: Three models of MI were generated: 1) proximal left circumflex (LCx) coronary artery occlusion involving the LA branch (LAI group); 2) proximal LCx occlusion not involving the LA branch (LCx group); and 3) left anterior descending (LAD) occlusion (LAD group).