Publications by authors named "Gonzalo Gomez-Campillos"
Article Synopsis
- Carbapenems are essential antibiotics but are losing effectiveness due to metallo-β-lactamases (MBLs), which are enzymes that break them down.
- Researchers discovered indole-2-carboxylates (InCs) as new inhibitors that can effectively target MBLs, maintaining activity against all major clinically relevant classes of these enzymes.
- In laboratory tests, InCs not only restored the effectiveness of carbapenems against drug-resistant Gram-negative bacteria but also demonstrated a good safety profile and strong efficacy when combined with the antibiotic meropenem in animal models of infection.
Org Biomol Chem
October 2018
Article Synopsis
- * Initial attempts to synthesize a modified tetrapeptide faced challenges, prompting a new approach involving the late introduction of (E)- and (Z)-dehydrobutyrines through selenoxide elimination.
- * The synthesis process involved creating advanced macrocyclic precursors using modified hexapeptides and dipeptidyl glycerates, while ensuring proper protection of specific functional groups during the reaction.
J Org Chem
September 2016
Article Synopsis
- Researchers have developed a method to selectively produce different types of nitrogen-containing compounds, specifically 2,5-dihydro-1H-pyrroles, 3,6-dihydro-2H-pyrans, and pyrroles, using metal-catalyzed reactions of specific amino alcohols.
- The process utilizes gold catalysts for one type of reaction that creates 2,5-dihydro-1H-pyrroles and palladium catalysts for another reaction that results in 3,6-dihydro-2H-pyrans through a selective cyclization method.
- The differences in product formation due to the type of catalyst and structural variations in the amino alcohols can be
Article Synopsis
- A new method for preparing fused δ-sultone derivatives without using metal catalysts has been created, starting from hydroxyallenynes.
- This process involves a sulfonylation and rearrangement using a specific sulfonyl chloride, leading to the production of 1,3-dien-2-yl arenesulfonates.
- The resulting enynes then undergo a radical cascade that allows for the synthesis of various compounds, including complex polycycles through stereoselective reactions, supported by both experimental and computational studies of the reaction mechanisms.
Article Synopsis
- - A new method for creating bicyclic azocine-β-lactams has been developed without using metals, marking a novel approach in chemical synthesis.
- - The process involves heating nonconjugated 2-azetidinone-tethered bis(allenes) using microwave irradiation to form eight-membered rings.
- - The researchers conducted experiments to analyze this reaction and also explored its underlying mechanism through Density Functional Theory (DFT) studies.
Chem Commun (Camb)
May 2014
Article Synopsis
- The study focuses on a gold-catalyzed reaction that combines specific compounds, resulting in the production of pyrazines.
- Researchers used deuterium labeling and computational methods to investigate the underlying mechanism of this chemical process.
- The findings contribute to a deeper understanding of how these reactions work at a molecular level.
Article Synopsis
- - Lactam-tethered allenols, derived from α-oxolactams, are used to react with selenenylating agents to create two different types of compounds: spirocyclic selenolactams and selenoquinolones, depending on the chosen reagents and starting materials.
- - The process involves either oxycyclization to form spirocyclic structures or ring expansion to produce quinolone structures, showcasing the versatility of these reactions.
- - Additionally, the newly synthesized compounds have been tested for their biological activity against four different human cancer cell lines, indicating potential therapeutic applications.
