Publications by authors named "Gonzalo E Astudillo"
Int J Mol Sci
November 2022
Article Synopsis
- Recent research highlights PSMD1 and PSMD3 as potential prognostic biomarkers in both chronic myeloid leukemia and various solid tumors.
- In acute myeloid leukemia (AML), higher levels of PSMD3 expression were linked to poorer overall survival in patients with FLT3 mutations, while knocking down PSMD3 in cell lines improved survival rates in experimental models.
- The study also uncovered additional proteasome subunits that were upregulated in FLT3-mutated AML patients, indicating a need to explore these components as prognostic indicators for AML and other cancers.
