Tuberculous meningitis: do modern diagnostic tools offer better prognosis prediction?

Background: The British Medical Research Council (BMRC) staging has been extensively used to evaluate the disease severity and establish the approximate prognosis of tuberculous meningitis.

Aims: This study aimed at analyzing the predictive accuracy for mortality and neurological sequelae of a set of clinical features, laboratory tests and imaging.

Methods: We compared the British Medical Research Council (BMRC) staging with a new scoring proposal to predict the prognosis of patients with Central Nervous System Tuberculosis.

Tuberculous meningitis: does lowering the treatment threshold result in many more treated patients?

Objective: To determine how many more patients would be treated when lowering the treatment threshold for tuberculous meningitis.

Methods: From 1989 to 2004 findings of patients with symptoms lasting more than 1 week and inflammatory changes of cerebrospinal fluid (CSF) were collected. Several models of latent class analysis were tested.