CPEB4-CLOCK crosstalk during temporal lobe epilepsy.

Objective: Posttranscriptional mechanisms are increasingly recognized as important contributors to the formation of hyperexcitable networks in epilepsy. Messenger RNA (mRNA) polyadenylation is a key regulatory mechanism governing protein expression by enhancing mRNA stability and translation. Previous studies have shown large-scale changes in mRNA polyadenylation in the hippocampus of mice during epilepsy development.

Effect of nutritional supplement based on melatonin on the intraocular pressure in normotensive subjects.

Purpose: To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects.

Patients And Methods: A short-term prospective study was designed. Sixty-seven normotensive subjects were recruited.