Publications by authors named "Gonzalez-Sansegundo C"

Article Synopsis
  • The study explores how the timing of androgen-deprivation therapy (ADT) relative to radiotherapy (RT) affects outcomes for prostate cancer, particularly comparing prostate-only RT (PORT) and whole-pelvis RT (WPRT).
  • Researchers analyzed data from 12 randomized trials involving 7,409 patients and utilized advanced statistical methods to assess the impact of ADT sequencing on metastasis-free survival and overall survival.
  • Findings indicated that for patients receiving PORT, concurrent/adjuvant ADT resulted in better metastasis-free survival and lower rates of prostate cancer-specific mortality, whereas WPRT showed no significant differences in outcomes based on ADT timing.
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Purpose: We compared biochemical control and quality of life with intermittent (6 months) versus continuous (36 months) androgen deprivation therapy (ADT) in a non-inferiority randomized phase 3 trial in patients with biochemical failure (BF) after external beam radical radiotherapy (EBRT).

Materials And Methods: Patients were stratified according to the Gleason score (GS) and were classified as low risk with a GS < 6 and 7 (3 + 4) and high risk with a GS of 7 (4 + 3) and >7. Patients were followed with PSA determinations and quality-of-life assessments (QLQ C-30 and QLQ PR-25) every 6 months for a period of 3 years.

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Purpose: The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC).

Patients And Methods: From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed.

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Objective: To analyze prognostic factors in patients treated with intraoperative electrons containing resective surgical rescue of locally recurrent gynecological cancer (LRGC).

Methods: From January 1995 to December 2012, 35 patients with LRGC [uterine cervix (57%), endometrial (20%), ovarian (17%), vagina (6%)] underwent extended [multiorgan (54%), bone (9%), soft tissue (54%), vascular (14%)] surgery and intraoperative electron-beam radiation therapy [IOERT (10-15 Gy)] to the pelvic recurrence tumor bed. Sixteen (46%) patients also received external beam radiation therapy [EBRT (30.

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Cases: We present four cases of ocular melanosis. Choroidal melanoma was detected in all of them. Three eyes had decreased visual acuity and were enucleated because of their large, active tumours.

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