Publications by authors named "Gonzalez-Sansegundo C"
Article Synopsis
- The study explores how the timing of androgen-deprivation therapy (ADT) relative to radiotherapy (RT) affects outcomes for prostate cancer, particularly comparing prostate-only RT (PORT) and whole-pelvis RT (WPRT).
- Researchers analyzed data from 12 randomized trials involving 7,409 patients and utilized advanced statistical methods to assess the impact of ADT sequencing on metastasis-free survival and overall survival.
- Findings indicated that for patients receiving PORT, concurrent/adjuvant ADT resulted in better metastasis-free survival and lower rates of prostate cancer-specific mortality, whereas WPRT showed no significant differences in outcomes based on ADT timing.
Purpose: We compared biochemical control and quality of life with intermittent (6 months) versus continuous (36 months) androgen deprivation therapy (ADT) in a non-inferiority randomized phase 3 trial in patients with biochemical failure (BF) after external beam radical radiotherapy (EBRT).
Materials And Methods: Patients were stratified according to the Gleason score (GS) and were classified as low risk with a GS < 6 and 7 (3 + 4) and high risk with a GS of 7 (4 + 3) and >7. Patients were followed with PSA determinations and quality-of-life assessments (QLQ C-30 and QLQ PR-25) every 6 months for a period of 3 years.
Purpose: The goal of the present study was to analyze prognostic factors in patients treated with external-beam radiation therapy (EBRT), surgical resection and intraoperative electron-beam radiotherapy (IOERT) for oligorecurrent gynecological cancer (ORGC).
Patients And Methods: From January 1995 to December 2012, 61 patients with ORGC [uterine cervix (52 %), endometrial (30 %), ovarian (15 %), vagina (3 %)] underwent IOERT (12.5 Gy, range 10-15 Gy), and surgical resection to the pelvic (57 %) and paraaortic (43 %) recurrence tumor bed.
Objective: To analyze prognostic factors in patients treated with intraoperative electrons containing resective surgical rescue of locally recurrent gynecological cancer (LRGC).
Methods: From January 1995 to December 2012, 35 patients with LRGC [uterine cervix (57%), endometrial (20%), ovarian (17%), vagina (6%)] underwent extended [multiorgan (54%), bone (9%), soft tissue (54%), vascular (14%)] surgery and intraoperative electron-beam radiation therapy [IOERT (10-15 Gy)] to the pelvic recurrence tumor bed. Sixteen (46%) patients also received external beam radiation therapy [EBRT (30.
Cases: We present four cases of ocular melanosis. Choroidal melanoma was detected in all of them. Three eyes had decreased visual acuity and were enucleated because of their large, active tumours.
View Article and Find Full Text PDF