Publications by authors named "Gonzalez-Gutierrez J"

The hydration shell of a protein is so important and an integral part of it, that protein's structure, stability and functionality cannot be conceived in its absence. This layer has unique properties not found in bulk water. However, ions, always present in the protein environment, disturb the hydration shell depending on their nature and concentration.

View Article and Find Full Text PDF

Introduction: Measuring social value has always been a challenge for organizations that generate such value, including foundations, NGOs, social enterprises, and governmental entities. Often, the benefits of these initiatives are perceived as intangible or long-term, making them difficult to quantify. Assessing social value demonstrates the impact of investments and accountability to stakeholders.

View Article and Find Full Text PDF
Article Synopsis
  • Myval technology is a new balloon-expandable option for treating heart valve issues, emerging after the established Edwards system, and its usage is increasing despite some debated points.
  • A thorough literature review covering studies from December 2016 to May 2024 showed Myval to be effective for native aortic stenosis with low mortality and complication rates, and its performance compares favorably to other devices.
  • The findings also indicate that Myval is safe for various off-label uses, achieving high success rates across different heart valve procedures, although more extensive studies are needed to confirm these results.
View Article and Find Full Text PDF
Article Synopsis
  • User-friendly assessment tools for malnutrition are essential, and this study focused on a personalized nutrition intervention using a new oral nutritional supplement and AI technology to track outcomes in malnourished patients.
  • The study included 65 patients and showed significant improvements over three months, with weight loss decreasing, and a drop in the prevalence of malnutrition and severe malnutrition.
  • Additionally, older patients experienced gains in muscle thickness, strength, and function, indicating that tailored interventions can effectively enhance nutrition and combat malnutrition in patients with disease-related issues.
View Article and Find Full Text PDF
Article Synopsis
  • The study evaluated the effectiveness of the Vasopressor test (VPT) in patients with functional mitral regurgitation (MR) and left ventricular dysfunction undergoing transcatheter edge-to-edge repair (TEER).* -
  • Out of 1115 patients, those who underwent VPT had higher rates of significant MR and greater overall mortality at one year compared to those who did not undergo the test, indicating a potentially higher risk profile.* -
  • Despite the increased mortality rates in the VPT group, other key outcomes like heart failure readmissions and cardiovascular mortality showed no significant differences, suggesting VPT can aid in managing high-risk patients without worsening long-term outcomes.*
View Article and Find Full Text PDF
Article Synopsis
  • ALS is a progressive neurodegenerative disease associated with high rates of malnutrition, which can affect patient outcomes; this study aims to evaluate the effectiveness of muscle ultrasonography in identifying malnutrition and predicting prognosis in ALS patients.
  • The study analyzed 37 ALS patients using various methods to assess nutritional status, including anthropometric measurements and electrical bioimpedance analysis, alongside muscle ultrasonography of the quadriceps to evaluate both muscle mass and quality.
  • Results found that nearly 46% of patients were malnourished according to established criteria, with significant correlations between muscle mass measured by ultrasound and various markers of body composition, indicating the potential usefulness of muscle ultrasonography in ALS management.
View Article and Find Full Text PDF

Objective: Cognitive reappraisal and distraction modulate pain; however, little is known about their effectiveness at different levels of pain intensity. Thus, the aim of this study has been to analyze the differential efficacy of both strategies to reduce perceived pain intensity and pain unpleasantness in low and moderate pain levels.

Method: 3 (emotion regulation strategy: cognitive reappraisal, distraction, and control) × 2 (intensity of the painful stimuli: low and moderate intensity) × 2 (time: pretest and posttest) mixed factorial design.

View Article and Find Full Text PDF

Background: Progression diets after bariatric surgery (BS) are restricted in calories and protein, and they may induce a worsening of body composition. The aim of this study was to evaluate the effect of a modified diet with an oral nutritional supplement that is hyperproteic and normocaloric over the body composition.

Methods: A two-arm ambispective observational cohort study was designed.

View Article and Find Full Text PDF

The analysis of structures in dried droplets has made it possible to detect the presence and conformational state of macromolecules in relevant biofluids. Therefore, the implementation of novel drying strategies for pattern formation could facilitate the identification of biomarkers for the diagnosis of pathologies. We present an experimental study of patterns formed by evaporating water-diluted blood droplets on a vertical surface.

View Article and Find Full Text PDF
Article Synopsis
  • * Case presentations highlight two women who experienced severe hair tangling, leading to matted and dirty-appearing hair masses, often after using certain products or due to scalp conditions.
  • * Diagnosis is aided by trichoscopy, and treatment typically involves cutting the matted hair, with early intervention sometimes allowing for manual separation of the tangles.
View Article and Find Full Text PDF
Article Synopsis
  • * In trials involving 44 patients, mostly older women, 95.5% showed clinical improvement, with significant gains in quality of life scores, functional class, and walking distance, while serious complications were rare.
  • * After one year, the treatment led to a sustained reduction in symptoms and improved heart function, with 63.8% of patients experiencing complete relief from caval backflow, which is linked to lower levels of heart failure-related biomarkers.
View Article and Find Full Text PDF

Additive manufacturing (AM) nowadays has become a supportive method of traditional manufacturing. In particular, the medical and healthcare industry can profit from these developments in terms of personalized design and batches ranging from one to five specimens overall. In terms of polymers, polyolefins are always an interesting topic due to their low prices, inert chemistry, and crystalline structure resulting in preferable mechanical properties.

View Article and Find Full Text PDF

Background: Transcatheter aortic valve replacement (TAVR) in non-calcified aortic regurgitation (NCAR) is an off-label procedure. The balloon-expandable Myval includes extra-large sizes (30.5 mm and 32 mm) of interest in this setting.

View Article and Find Full Text PDF

The current study presents the effect of the backbone as an important binder component on the mechanical, rheological, and thermal properties of Aluminium (Al) alloy feedstocks. A thermoplastic elastomer (TPE) main binder component was blended with either polypropylene (PP), grafted-maleic anhydride-PP (PPMA), or grafted-maleic anhydride-PPwax (PPMAwax) plus PP, as the backbone. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) tests were performed to investigate the thermal properties of binder systems and feedstocks.

View Article and Find Full Text PDF

Triple-shape polymers can memorize two independent shapes during a controlled recovery process. This work reports the 4D printing of electro-active triple-shape composites based on thermoplastic blends. Composite blends comprising polyester urethane (PEU), polylactic acid (PLA), and multiwall carbon nanotubes (MWCNTs) as conductive fillers were prepared by conventional melt processing methods.

View Article and Find Full Text PDF

Powder injection molding (PIM) is a well-known technique to manufacture net-shaped, complicated, macro or micro parts employing a wide range of materials and alloys. Depending on the pressure applied to inject the feedstock, this process can be separated into low-pressure (LPIM) and high-pressure (HPIM) injection molding. Although the LPIM and HPIM processes are theoretically similar, all steps have substantial differences, particularly feedstock preparation, injection, and debinding.

View Article and Find Full Text PDF

This work aims to better understand the type of thermoplastic binders required to produce highly loaded copper filaments that can be successfully printed via low-cost filament-based material extrusion (MEX). Compounding feedstock material with 55 vol.% of copper and three multi-component binder systems has been performed.

View Article and Find Full Text PDF

Within this work, we demonstrate in-situ alignment of the easy axis single-crystal magnetic particles inside a polymer matrix using fused filament fabrication. Two different magnetic materials are investigated: (i) Strontium hexaferrite inside a PA6 matrix, fill grade: 49 vol% and (ii) Samarium iron nitride inside a PA12 matrix, fill grade: 44 vol%. In the presence of the external alignment field, the strontium hexaferrite particles inside the PA6 matrix can be well aligned with a ratio of remnant magnetization to saturation magnetization in an easy axis of 0.

View Article and Find Full Text PDF

Fibromyalgia is a chronic pain syndrome characterized by dysfunctional processing of nociceptive stimulation. Neuroimaging studies have pointed out that pain-related network functioning seems to be altered in these patients. It is thought that this clinical symptomatology may be maintained or even strengthened because of an enhanced expectancy for painful stimuli or its forthcoming appearance.

View Article and Find Full Text PDF

The vast majority of transcatheter valve-in-valve (ViV) mitral procedures have been reported with the SAPIEN family. We aimed to report the preliminary experience with the Myval balloon-expandable device in this setting. Multicenter retrospective study of high-risk surgical patients with mitral bioprosthesis degeneration undergoing transcatheter ViV implantation with Myval device.

View Article and Find Full Text PDF