Chronic viral mimicry induction following p53 loss promotes immune evasion.

Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood.

Positive secular trend in excess body weight in adolescents: A comparative study of 2007 and 2017/2018 data.

Background: This study aimed to compare the prevalence of excess weight in adolescents living in Florianópolis, Santa Catarina, Brazil, from 2007 to 2017/2018 and assess associations with physical activity level, screen time, muscle strength, and cardiorespiratory fitness.

Methods: Two cross-sectional surveys were conducted with adolescents (14 to 19 years old). The body mass index was calculated from measurements of body weight (kg) and height (m2).

Efficient photoelectrochemical real textile wastewater detoxification using photoanodes of CN-BiVO.

Photoelectrochemical systems utilizing solar energy have garnered significant attention for their sustainability in remediating contaminated water. This study focuses on advancing photoanode development through the utilization of carbon nitrides (CN) and bismuth vanadate (BiVO), two promising semiconductor materials renowned for their efficient electron-hole pair separation leading to enhanced photocatalytic activity. Four distinct materials were synthesized and compared: BiVO over CN, CN over BiVO, and pristine BiVO and CN.

Secular trends in body image dissatisfaction and associated factors among adolescents (2007-2017/2018).

Objective: To assess secular trends in body image dissatisfaction and associated factors among adolescents over a 10-year period (2007-2017/2018).

Methods: The sample included 1,479 (2007, n = 531; 2017/2018, n = 948) high school adolescents of both sexes, aged 14 to 18 years, of schools in a city in southern Brazil, in 2007 and 2017/2018. Data were collected on sex, age, physical activity (IPAQ, short form), anthropometric measurements (body weight, height, and triceps and subscapular skinfolds), and body image dissatisfaction (figure rating scale).

Toward efficient electrocatalytic degradation of iohexol using active anodes: A laser-made versus commercial anodes.

The X-ray iodinated contrast medium iohexol is frequently detected in aquatic environments due to its high persistence and the inefficiency of its degradation by conventional wastewater treatments. Hence, the challenge faced in this study is the development of an alternative electrochemical treatment using active anodes. We investigate the oxidation of iohexol (16.

MET overexpression and intratumor heterogeneity in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is among the ten most frequent and deadly cancers, without effective therapies for most patients. More recently, drugs targeting deregulated growth factor signaling receptors have been developed, such as HGF-MET targeted therapy. We assessed MET and HGF genetic alterations and gene and protein expression profiles in ESCC patients from the Brazilian National Cancer Institute and publicly available datasets, as well as the intratumor heterogeneity of the alterations found.

DNA hypomethylating agents increase activation and cytolytic activity of CD8 T cells.

We demonstrate that DNA hypomethylating agent (HMA) treatment can directly modulate the anti-tumor response and effector function of CD8 T cells. In vivo HMA treatment promotes CD8 T cell tumor infiltration and suppresses tumor growth via CD8 T cell-dependent activity. Ex vivo, HMAs enhance primary human CD8 T cell activation markers, effector cytokine production, and anti-tumor cytolytic activity.

Novel Ti/RuOIrO anode to reduce the dangerousness of antibiotic polluted urines by Fenton-based processes.

The treatment of hospital wastewater is very complex, so treating polluted human urine is a significant challenge. Here, we tested a novel MMO-Ti/RuOIrO electrode to reduce the ecotoxicity risk of hospital urines contaminated with antibiotics. This electrode was used as the anode in electro-Fenton (EF) and photoelectro-Fenton (PhEF) processes.

Influence of the doping level of boron-doped diamond anodes on the removal of penicillin G from urine matrixes.

The objective of this study is to understand the influence of the characteristics of boron-doped diamond anodes on the degradation of Penicillin G contained in urine. Therefore, five commercial BDD anodes with different boron doping levels (100 ppm - 8000 ppm) were studied. These electrodes were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and electrolysis.

Body image dissatisfaction in adolescents: Comparison with physical activity, teasing and social support.

This study aimed to compare the adolescents' body dissatisfaction with physical activity, teasing during physical activity and social support. Participants were 938 Brazilian adolescents aged 15-19 years. Study variables were investigated through questionnaires.

hypermethylation and decreased expression in esophageal squamous cell carcinoma and histologically normal tumor surrounding esophageal cells.

Background: Esophageal squamous cell carcinoma (ESCC) is one of the 10 most incident cancer types in the world, and it is mainly associated with tobacco and alcohol consumption. ESCC mortality rates stand very close to its incidence, which is a direct consequence of a late diagnosis and an inefficient treatment. Although this scenery is quite alarming, the major molecular alterations that drive this carcinogenesis process remain unclear.

Low-intensity LED therapy (λ 640 ± 20 nm) on saphenectomy healing in patients who underwent coronary artery bypass graft: a randomized, double-blind study.

Myocardial revascularization surgery (CABG) is the most appropriate treatment for coronary artery disease. Currently, the great challenge is to reduce postoperative complications, such as wound infections, dehiscence, pain, and patients' quality of life. The saphenectomy is the target of complications in 10% of cases, which can cause greater morbidity, time, and cost of hospitalization.

Effectiveness of Low-Intensity Laser Therapy on Tissue Repair Following Saphenectomy in Patients Who Underwent Coronary Artery Bypass Graft: A Randomized, Double-Blind Study.

Objective: To verify the effectiveness of low-intensity laser therapy (LLLT) on tissue repair following saphenectomy during postoperative period in patients having undergone coronary artery bypass graft (CABG).

Materials And Methods: A randomized clinical trial, controlled and double-blind study was conducted with 40 volunteers, divided into 2 groups: a placebo group (PG, n = 20) and a laser group (LG, n = 20). The patients in the LG group were irradiated with laser during saphenectomy (InGaAlP, λ 660 nm, energy density 6 J/cm) daily from the first to the fourth postoperative day.

Low-intensity laser (660 NM) has analgesic effects on sternotomy of patients who underwent coronary artery bypass grafts.

Background: The aim of this study was to evaluate the efficacy of low-level laser therapy for reducing the acute pain of sternotomy in patients who underwent a coronary artery bypass graft (CABG).

Methods: This study was conducted with ninety volunteers who electively submitted to CABG. The volunteers were randomly allocated into three groups of equal size (n = 30): control, placebo, and laser (λ of 660 nm and spatial average energy fluency of 1.

Low-intensity laser (660 nm) on sternotomy healing in patients who underwent coronary artery bypass graft: a randomized, double-blind study.

The aim of this study was to analyze the healing effects of low-level laser therapy (LLLT) on the longitudinal sternotomy incisions of patients who underwent coronary artery bypass graft (CABG). The volunteers were randomized into three groups of equal size (n = 30): control, placebo, and laser (λ = 660 nm and spatial average energy fluency [SAEF] = 1.06 J/cm).

Photobiomodulation (Laser and LED) on Sternotomy Healing in Hyperglycemic and Normoglycemic Patients Who Underwent Coronary Bypass Surgery with Internal Mammary Artery Grafts: A Randomized, Double-Blind Study with Follow-Up.

Background And Objective: This study aimed at analyzing the healing effects of low-level laser therapy (LLLT) (λ620 nm, 6 J/cm) and light-emitting diode (LED) therapy (λ640 nm, 6 J/cm) on the longitudinal sternotomy incisions of hyperglycemic and normoglycemic patients who underwent coronary artery bypass grafting (CABG).

Materials And Methods: 120 volunteers were electively submitted to CABG and were randomly allocated into four different groups of equal size (n = 30): control, placebo, laser (λ of 640 nm and spatial average energy fluency [SAEF] of 1.06 J/cm), and LED (λ of 660 ± 20 nm and SAEF of 0.

[Prenatal care and risk factors associated with premature birth and low birth weight in the a capital in the Brazilian Northeast].

The main determinants of the risk of mortality in the neonatal period are low birth weight and premature birth. The study sought to analyze the adequacy of prenatal care and risk factors associated with premature birth and low birth weight in a northeastern Brazilian capital. This is a case-control study.

Low-Level Laser and Light-Emitting Diode Therapy for Pain Control in Hyperglycemic and Normoglycemic Patients Who Underwent Coronary Bypass Surgery with Internal Mammary Artery Grafts: A Randomized, Double-Blind Study with Follow-Up.

Objective: This study aimed to evaluate the efficacy of low-level laser therapy (LLLT) and light-emitting diodes (LEDs) for reducing pain in hyperglycemic and normoglycemic patients who underwent coronary artery bypass surgery with internal mammary artery grafts.

Methods: This study was conducted on 120 volunteers who underwent elective coronary artery bypass graft (CABG) surgery. The volunteers were randomly allocated to four different groups of equal size (n = 30): control, placebo, LLLT [λ = 640 nm and spatial average energy fluence (SAEF) = 1.

Recurrent acute thermal lesion induces esophageal hyperproliferative premalignant lesions in mice esophagus.

Hot beverage consumption is a risk factor for esophageal squamous cell carcinoma, but the underlying mechanisms are still unknown. We developed an experimental mouse model to understand the mechanism of thermal lesion to esophageal carcinogenesis. Female BALB/c mice were treated by gavage with water at different temperatures three times a week and nitrosamines in the drinking water.

Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas.

Background: Esophageal squamous cell carcinoma (ESCC) shows a 5-year survival rate below 10%, demonstrating the urgency in improving its treatment. Alterations in epidermal growth factor receptors are closely related to malignancy transformation in a number of tumors and recent successful targeted therapies have been directed to these molecules. Therefore, in this study, we analyzed the expression of EGFR and HER2 and evaluated EGFR mutation profile as well as the presence of mutations in hotspots of KRAS and BRAF in ESCC patients.