[Influence of combined rehabilitation treatment including novel non-pharmacological technologies on immune system of patients with seronegetive spondylarthritis].

The immune system was studied in 90 patients with seronegative spondylarthritis (SNSA). Of them, 60 patients had ankylosing spondylarthritis (30 patients with central and 30 patients with peripheral forms) and 30 patients with reactive arthritis. SNSA patients were found to have secondary immunodeficiency.

[Immunological response of patient with chronic salphingo-oophoritis to interference currents used in electrical sleep and balneotherapy].

The study included 105 women of a reproductive age with chronic nonspecific salpingooophoritis. The women were transcerebrally exposed to interference currents (IC). The immunological examination revealed that IC have an immunocorrecting effect on both cellular and humoral links of the immune system, correct imbalance of the immunoregulatory subpopulations confirmed by increased immunoregulatory index.

[The use of cryomassage in the rehabilitative treatment of patients with duodenal peptic ulcer at the polyclinic stage].

The proposed technique of cryomassage in outpatient setting promotes a complete healing of duodenal ulcer (DU) in patients with DU exacerbation. Healing of the ulcer is accompanied by improvement of blood flow in the zones of segmental innervation of the gastroduodenal system and by recovery of impaired cellular and humoral immunity in most of the patients.

[The interauricular laser therapy of rheumatoid arthritis].

Investigations have proved the ability of interauricular low-intensity infrared laser therapy (0.89 nm, 7.6 J/cm) to produce anti-inflammatory, immunomodulating action in patients with rheumatoid arthritis.

[The effect of carbon dioxide baths and applications of low-temperature peloids on the immune function of patients with psoriatic arthritis].

A trial of dry air effervescent baths and low-temperature peloid applications was made in 109 patients with psoriatic arthritis (PA). Marked response was achieved in patients who had received combined therapy with the above two modalities. The effect presented with lower articular index, weaker skin involvement, improvement of blood picture.

[The combined treatment of patients with chronic nonspecific salpingo-oophoritis using a low-frequency magnetic field and iodobromine water].

The studies of 116 females with chronic nonspecific salpingo-oophoritis demonstrate that combination of low-frequency magnetic field with iodine-bromine water effectively corrects immunological indices, i.e. improves T- and B-cell immunity, production of IgM and IgA, proportion of immunoregulatory subpopulations of T-lymphocytes.

[The effect of a low-frequency magnetic field on the clinico-immunological indices of patients with chronic inflammatory diseases of the organs of the female genital system].

Low-frequency magnetic field generated by the vaginal inductor used in 120 females with chronic genital inflammation promoted a decrease in leukocytosis, elevation of total population of T-lymphocytes, inhibition of high proliferative activity in PHA test. However, marked immunocorrection was not reached.

[The use of sodium chloride baths in patients with chronic bronchitis].

80 patients with chronic bronchitis took baths with sodium chloride concentration 20, 40, 60 g/l and temperature 37-38 degrees C. The baths produced a positive effect on central and regional hemodynamics, reduced inflammation and sensitization.

[The effect of the administration of different estrogens on the content of estrogen receptors in the cytosol and nuclear subfractions of liver cells and on the level of angiotensinogen in the blood plasma of rats].

The level of estrogen receptors (ER) in the cytosol and nuclear subfractions of female rat hepatocytes was studied 1 h and plasma angiotensinogen (AG) concentration 24 h after single and multiple administration of different doses of estradiol (E2) and synthetic estrogens. Synthetic weakly metabolized estrogens, used at doses corresponding to physiological concentrations of the natural female sex steroid, were shown to be much more effective than E2 in relation to ER redistribution between the cytosol and nuclear fractions of hepatocytes as well as in relation to the stimulation of AG production by the liver. Differences in the ER level in hepatocytic nuclei 1 h after single or multiple administration of the same estrogen were undetectable.

[The dynamics of the immunobiological effects in transcerebral microwave exposures].

The trend in immunobiological responses to transcerebral action of decimeter microwaves was studied in intact rabbits. Transcerebral microwaves (120 mW/cm2) can alter functional activity of certain links of endocrine system due to possible activation of hypothalamus and hypophysis exposed to microwave electromagnetic field. Such exposure given in courses at early stages leads to an increase in the number of antibody-forming cells in the spleen, whereas total number of splenocytes is on the decrease.

[Effect of estradiol and other endocrine factors on the level and dynamics of estrogen receptors in the liver cells of rats].

The authors studied the effects of different doses of estradiol (E2) on the level of estrogen receptors (ER) in female rat hepatocytes and the dynamics of ER distribution between the cytosol and nuclear cell fractions and compared the changes in the ER level in the liver in different endocrine states of the body. It was shown that the ER level in hepatocytes was far lower than in uterine cells and drastically increased during puberation and after ovariectomy. It was also found that the ER level in hepatocytes was dependent on pituitary functions.

[Comparative analysis of estrogen receptor level in the liver and angiotensinogen level in the blood plasma of rats after administration of estradiol in association with other endocrine factors].

A study was made of the level of hepatocyte estrogen receptors (ER) and of angiotensinogen [AG) in the blood plasma of rats after the administration of different doses of estradiol (E2) in combination with the exposure to some other endocrine factors. A single administration of E2 has been shown to cause two types of effects depending of the dose of a hormone administered and the time following injection: an increase in the AG level in the plasma and interrelated changes of the ER content in the cytosol and hepatocyte nuclei. These effects were most noticeable after the administration of 500 micrograms of E2.

[Effect of estradiol and a series of other endocrine factors on the angiotensinogen level in rat blood plasma].

The effects of estradiol (E2) and some other endocrine factors on rat plasma angiotensinogen (AG) have been studied. AG was determined by RIA. Both single and multiple injections of E2 to female rats were shown to cause a dose-dependent increase in AG in the blood.

[Comparative study of the interaction between different forms of estrogen receptors and cell nuclei].

A comparative in vitro study of interaction of estradiol (E2) complexes with different forms of cytosol estrogen receptors (ER) from rat liver, kidney and uterus, and cell nuclei was carried out. It was shown that complexes of E2 with ER of whole liver and kidney cytosol of female rats as well as complexes of E2 with forms I and II of liver ER separated from one another and partially purified can be translocated into cell nuclei, similar to the estrogen-receptor complexes (ERC) of uterine cytosol. ERC, which contain an unusual estrogen-binding protein of male rat liver cytosol, do not bind to the nuclei in vitro.

[Cytoplasm to nucleus translocation patterns of different forms of hepatic estrogen receptors].

Interaction between cell nuclei and the complexes of estradiol (E2) with uterine cytosol estrogen receptors (ER) or with different forms of female and male rat liver cytosol ER was studied and compared. The complexes of E2 with forms I and II of liver ER are capable to translocate to the cell nuclei similarly to E2 receptor complexes of the uterus. The complexes of E2 with an unusual male rat liver estrogen-binding protein do not bind to the nuclei.