Publications by authors named "Gongyao Tang"
Adiponectin attenuates Ang Ⅱ-induced TGFβ1 production in human mesangial cells via an AMPK-dependent pathway.
Biotechnol Appl Biochem
October 2016
Glomerulosclerosis is a key element in end-stage renal failure. Angiotensin II (Ang II) plays an important role in modulating cell growth and extracellular matrix (ECM) synthesis and degradation. Adiponectin, a protein derived from adipocytes, is primarily involved in regulating glucose levels and fatty acid break down.
View Article and Find Full Text PDF[Expression and regulation of adiponectin in human renal glomerular endothelial cells].
Zhonghua Yi Xue Za Zhi
March 2010
Objective: To investigate the expression and regulation of adiponectin in human renal glomerular endothelial cells (HRGEC).
Method: The adiponectin expression in human renal tissue was examined with immunohistochemistry assay, and the adiponectin mRNA and protein expression of HRGEC was confirmed by reverse transcription polymerase chain reaction (RT-PCR) and Western blot, respectively. PCR product was sequenced.
Article Synopsis
- Nitric oxide (NO) is a key molecule in body processes and can improve the healing properties of tendons, but flurbiprofen, a pain reliever, negatively affects healing.
- A study tested the effects of NO delivered through paracetamol on healing rat Achilles tendons by comparing it against paracetamol and a control (vehicle).
- The results showed that NO-paracetamol improved collagen content and organization in the healing tendon, while also decreasing water content and cross-sectional area, aligning with findings in human trials on tendinopathy.
[Expression of alpha 1 anti-trypsin in proximal tubular epithelial cell line].
Zhonghua Yi Xue Za Zhi
June 2006
Objective: To investigate the expression and regulation of alpha 1 anti-trypsin (AAT) in tubular epithelial cells.
Methods: The expression of AAT in tubular epithelial cell line HKC was detected with indirect immunofluorescence assay and confirmed by reverse transcription polymerase chain reaction (PCR) in transcription level respectively, and PCR product was sequenced. In order to observe the response of HCK to LPS, the different concentrations of LPS (0, 0.
Objective: To investigate the effects of nonselective endothelin receptor antagonist bosentan on the progression of renal interstitial fibrosis following unilateral ureteral obstruction (UUO).
Methods: Eighteen female SD rats were randomly divided into 3 groups: intervention group (administered with bosentan for 7 days after left ureter ligation), animal model group (administered with solution of Arabic gum for 7 days left ureter ligation) and sham operation group (administered with Arabic gum for 7 days after sham operation). Seven days after the operation the rats were killed and their left kidneys were harvested.
Objective: (1) To investigate the effects of endothelin-1 (ET-1) on cell proliferation of cultured human renal interstitial fibroblasts (hRIFs), and the mRNA expression of type I Collagen (Col I), transforming growth factor-beta (TGF-beta), matrix metalloproteinase-1 (MMP-1) and tissue inhibitors of metalloproteinase-1, -2 (TIMP-1, TIMP-2) by hRIFs. (2) To investigate the changes of above effects after the hRIFs were pretreated with selective endothelin receptor-type A antagonist (ETaRA).
Methods: (1) The proliferation of hRIFs was determined by MTT method.