Publications by authors named "Gongqing Zhang"
Article Synopsis
- A disturbance in energy metabolism during severe hemorrhage can impair heart function, but improving energy supply may enhance survival.
- The study explores the effectiveness of histone deacetylase inhibitors (HDACIs), like valproic acid (VPA), in preserving cardiac energy metabolism while treating lethally hemorrhaged rats and hypoxic heart cells.
- VPA helps maintain ATP production and normal heart contractions by reducing lactate build-up and protecting mitochondrial function, primarily through the modulation of the MCL-1 gene, suggesting that HDACIs could be beneficial in preventing heart damage during severe blood loss.
