FOS B cells: Key mediators of immunotherapy resistance in diverse cancer types.

While immunotherapy has marked significant advances in cancer treatment, resistance remains a challenge. The complexity of the tumor microenvironment, particularly the role of B cell subpopulations, is a critical factor affecting treatment efficacy. In this study, we conducted analyses of single-cell RNA sequencing data from immunotherapy patients ( = 25) to explore the biomarker of immunotherapy resistance.

Neuromedin U receptor 1 deletion leads to impaired immunotherapy response and high malignancy in colorectal cancer.

Colorectal cancer (CRC) exhibits significant heterogeneity, impacting immunotherapy efficacy, particularly in immune desert subtypes. Neuromedin U receptor 1 (NMUR1) has been reported to perform a vital function in immunity and inflammation. Through comprehensive multi-omics analyses, we have systematically characterized NMUR1 across various tumors, assessing expression patterns, genetic alterations, prognostic significance, immune infiltration, and pathway associations at both the bulk sequencing and single-cell scales.

Fluorescent carbon nanodot-based rapid cell nucleus staining and application for diagnosis.

Cell nucleus status decides the activities of corresponding cells, making its rapid and effective staining important for revealing the actual condition of biological environment in life science and related fields. In this study, fast staining of cell nucleus is realized by fluorescent carbon nanodots (CDs). The staining mechanism is due to the positively charged CD surface-induced cell membrane penetration, which facilitates the CD-nucleus binding via electrostatic attraction.

Arid2-IR downregulates miR-132-3p through methylation to promote LPS-induced ALI in pneumonia.

Objective: Arid2-IR is a long non-coding RNA (lncRNA) that promotes renal injury, while its role in lipopolysaccharides (LPS)-induced acute lung injury (ALI) is unknown. Our preliminary sequencing analysis revealed an inverse correlation of Arid2-IR and miR-132-3p, which is known to suppress LPS-induced ALI. Therefore, Arid2-IR and miR-132-3p may interact with each other to participate in LPS-induced ALI in pneumonia.

Extracellular Vesicles Promote the Formation of Pre-Metastasis Niche in Gastric Cancer.

Globally, gastric cancer (GC) ranks fourth in the incidence of malignant tumors. The early clinical manifestations of GC lack specificity. Most patients are already at an advanced stage when they are first diagnosed, and their late progression is mainly due to peritoneal metastasis.

Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity.

Colon cancer (CC) is a prevalent malignancy worldwide. Approaches to specifically induce tumor cell death have historically been a popular research topic. Honokiol (HNK), which exhibits highly efficient and specific anticancer effects, is a biphenolic compound found in .

Modeling paraquat-induced lung fibrosis in reveals KRIT1 as a key regulator of collagen gene transcription.

Paraquat poisoning causes lung fibrosis, which often results in long-term pulmonary dysfunction. Lung fibrosis has been attributed to collagens accumulation, but the underlying regulatory pathway remains unclear. Here we use the genetically tractable as a model to study collagen gene transcription in response to paraquat.

Clinical utility of the mood and anxiety symptom questionnaire in a chinese sample of patients with pancreatic cancer.

A review of the literature indicates a higher prevalence of depression and anxiety in patients with pancreatic carcinoma compared with nonclinical populations. The aims of this study were to evaluate the tripartite model for assessing symptoms of depression and anxiety and develop a Chinese version of the Mood and Anxiety Symptoms Questionnaire-Short Form (MASQ-SF) in patients with pancreatic cancer. The final sample consisted of 1,029 patients with pancreatic cancer.