Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells.

Growth differentiation factor 11 (GDF11) is a putative systemic rejuvenation factor. In this study, we characterized the mechanism by which GDF11 reversed aging of mesenchymal stem cells (MSCs). In culture, aged MSCs proliferate slower and are positive for senescence markers senescence-associated β-galactosidase and P16 .

Development of a novel patient-reported outcome measure for orthognathic surgery.

Objectives: This study aimed to develop a new patient-reported outcome measure (PROM) to systematically and scientifically evaluate patients' subjective feelings after orthognathic surgery.

Methods: A literature review and semi-structured interviews were conducted to construct a conceptual framework and an item pool, followed by expert and patient surveys for measure construction. We conducted a clinical investigation to test the feasibility, reliability, and content validity of this measure.

Spatiotemporal analysis of land use pattern and stream water quality in southern Alberta, Canada.

Alberta has over 70% of total irrigated land in Canada and 13 irrigation districts are mainly located along the rivers in southern Alberta. The runoff and irrigation return flow can carry excess nutrients, pesticides, and sediments, which adversely affect the river water quality. In the present study, the comprehensive spatiotemporal analysis of land use pattern and stream water quality in southern Alberta was conducted.

The role of IFT140 in early bone healing of tooth extraction sockets.

Objectives: Primary cilium is a key organelle of regulating bone development and maintenance. The aim of this study is to investigate whether ciliary intraflagellar transporter protein 140 (IFT140) plays a positive role in extraction socket healing by promoting bone formation.

Materials And Methods: A left maxillary first molar extraction model was established using 6-week-old Ift140 (Ctrl group) and Ift140 , Osx-cre (cKO group) mice.

LncRNA Nron regulates osteoclastogenesis during orthodontic bone resorption.

Activation of osteoclasts during orthodontic tooth treatment is a prerequisite for alveolar bone resorption and tooth movement. However, the key regulatory molecules involved in osteoclastogenesis during this process remain unclear. Long noncoding RNAs (lncRNAs) are a newly identified class of functional RNAs that regulate cellular processes, such as gene expression and translation regulation.

High-glucose-induced miR-214-3p inhibits BMSCs osteogenic differentiation in type 1 diabetes mellitus.

Type 1 diabetes mellitus (T1DM) is an autoimmune insulin-dependent disease associated with destructive bone homeostasis. Accumulating evidence has proven that miRNAs are widely involved in the regulation of bone homeostasis. However, whether miRNAs also regulate osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in T1DM mice is under exploration.

The Role of IFT140 in Osteogenesis of Adult Mice Long Bone.

Primary cilia have a pivotal role in bone development and the dysfunctions of primary cilia cause skeletal ciliopathies. Intraflagellar transport (IFT) proteins are conserved mediators of cilium signaling. IFT sub-complex A is known to regulate retrograde IFT in the cilium.

Extracellular matrix protein DMP1 suppresses osteogenic differentiation of Mesenchymal Stem Cells.

Mesenchymal Stem Cells (MSCs) are self-renewing and multipotent stem cells which was investigated for diverse clinical applications. However, complex mechanism of MSCs fate determination is still not fully disclosed. Extracellular matrix (ECM) proteins contribute to maintain MSCs stemness by providing extracellular microenvironment.

Waste management under multiple complexities: inexact piecewise-linearization-based fuzzy flexible programming.

To tackle nonlinear economies-of-scale (EOS) effects in interval-parameter constraints for a representative waste management problem, an inexact piecewise-linearization-based fuzzy flexible programming (IPFP) model is developed. In IPFP, interval parameters for waste amounts and transportation/operation costs can be quantified; aspiration levels for net system costs, as well as tolerance intervals for both capacities of waste treatment facilities and waste generation rates can be reflected; and the nonlinear EOS effects transformed from objective function to constraints can be approximated. An interactive algorithm is proposed for solving the IPFP model, which in nature is an interval-parameter mixed-integer quadratically constrained programming model.

An integrated multi-level watershed-reservoir modeling system for examining hydrological and biogeochemical processes in small prairie watersheds.

Eutrophication of small prairie reservoirs presents a major challenge in water quality management and has led to a need for predictive water quality modeling. Studies are lacking in effectively integrating watershed models and reservoir models to explore nutrient dynamics and eutrophication pattern. A water quality model specific to small prairie water bodies is also desired in order to highlight key biogeochemical processes with an acceptable degree of parameterization.

Effect of short-chain organic acids and pH on the behaviors of pyrene in soil-water system.

The effects of five short-chain organic acids (SCOAs) on the behaviors of pyrene in soil-water system were investigated. The influences of the quantity and species of organic acids, pH, and soil dissolved organic matter were considered. The results showed the presence of SCOAs inhibited the adsorption and promoted the desorption of pyrene in the following order: citric acid>oxalic acid>tartaric acid>lactic acid>acetic acid.

Effects of fulvic acid concentration and origin on photodegradation of polycyclic aromatic hydrocarbons in aqueous solution: importance of active oxygen.

With an Xe arc lamp house as simulated sunlight, the influences of fulvic acid (FA) concentration and origins on photodegradation of acenaphthene, fluorine, phenanthrene, fluoranthene and pyrene in aqueous solution have been studied. Similar effects of FAs, collected from five places around China, on polycyclic aromatic hydrocarbon (PAH) photodegradation have been observed. Active oxygen was of significance in PAH photodegradation with the presence of FAs.

[Pollution of polycyclic aromatic hydrocarbons (PAHS) in middle and lower reaches of the Yellow River].

Samples of water, suspended particulate matter (SPM) and sediment in the Yellow River was analyzed. The total concentration of PAHs in the main river varies from 179 ng/L to 369 ng/L (sigma 15PAHs) in water, from 54 microg/kg to 155 microg/kg (sigma 13PAHs) in SPM dry weight, and from 31 microg/kg to 133 microg/kg (sigma 13PAHs) dry weight in sediment. The levels of PAHs in water of tributaries are higher than those in the corresponding sites in the main river, and concentrations of benzo(a)pyrene in most of the stations sampled are above drinking water standard.

Distribution and sources of polycyclic aromatic hydrocarbons in the middle and lower reaches of the Yellow River, China.

In this study, concentrations, distribution between different phases, transition along the Middle and Lower reaches of the Yellow River and possible sources of PAHs were assessed. Results demonstrated that the relative proportions of 15 PAHs in all stations of the main River were similar, with concentrations of benzo[a]pyrene all above drinking water standards in most of the stations sampled. PAHs concentrations in tributaries were higher than those in the corresponding sites in the main River.