Genetic Susceptibility, Mendelian Randomization, and Nomogram Model Construction of Gestational Diabetes Mellitus.

Context: Gestational diabetes mellitus (GDM) is a pregnancy-complicated disease that poses a risk to maternal and infant health. However, the etiology of the disease has been not yet elucidated.

Objective: To detect the genetic susceptibility and construct a nomogram model with significantly associated polymorphisms and key clinical indicators for early prediction of GDM.

Genetic variants of gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study.

Introduction: Gestational diabetes (GDM) is one of the common complications of female pregnancy, which seriously affects the health of mothers and their offspring. So far, the etiology has not been fully clarified.

Methods: A case-control study was conducted to clarify the relationship between Erb-b2 receptor tyrosine kinase 4 (ERBB4) functional tag genetic variants (rs1595064, rs1595065, rs1595066 and rs6719645) and the risk of GDM.

Systematically Evaluate The Effect Of Problem-Based Learning Method In The Teaching Of Epidemiology And Health Statistics In China.

Objective: To systematically evaluate the application of problem-based learning teaching in medical institutions.

Methods: The systematic review was conducted in China following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and comprised search for relevant studies on July 31, 2020, of the China National Knowledge Infrastructure, Wanfang, China Biology Medicine disc, Web of Science, National Center for Biotechnology Information, Excerpta Medica Database and PubMed databases. Quality of the included studies was assessed as adequate, uncertain or inadequate based on the Cochrane Handbook for Systematic Reviews of Interventions.

Systematic evaluation of the association between a missense variant in XRCC3 gene splicing site and the pathogenesis of ovarian cancer.

The effects and underlying mechanism of XRCC3 rs861539 on the risk of ovarian cancer (OC) are still unclear. Therefore, a meta-analysis of 10 studies containing 6,375 OC cases and 10,204 controls was performed for this topic. Compared with GG genotype, GA + AA genotypes could significantly decrease the OC risk, odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were 0.

Association of gene functional variants with gestational diabetes mellitus risk in a southern Chinese population.

Objective: To explore the relationship between angiotensin-converting enzyme 2 (ACE2) genetic variants and gestational diabetes mellitus (GDM) in a southern Chinese population.

Methods: Potential functional variants (rs2106809, rs6632677, and rs2074192) of were selected and genotyped in 566 GDM patients and 710 normal pregnaõncies in Guilin, China. The odds ratio (OR) and its corresponding 95% confidence interval (CI) were used to evaluate the association between genetic variant and GDM risk, and then the false positive report probability, multifactor dimensional reduction (MDR), and bioinformatics tools were used to confirm the significant association in the study.

Association and functional analysis of angiotensin-converting enzyme 2 genetic variants with the pathogenesis of pre-eclampsia.

Objective: The aim of this study was to investigate the relationship between potential functional single-nucleotide polymorphisms (SNPs) of the angiotensin-converting enzyme 2 () gene and the pathogenesis of pre-eclampsia (PE) in Guangxi, China.

Materials And Methods: A case-control study was conducted involving 327 PE cases and 591 age-matched, normal, singleton pregnant women. Potential functional gene variants (rs2106809 A>G, rs6632677 G>C, and rs2074192 C>T) were selected and genotyped using kompetitive allele-specific PCR.