Publications by authors named "Gong-ping Liang"
Article Synopsis
- Psoriasis vulgaris (PV) is a chronic autoimmune skin disease characterized by immune dysfunction, particularly involving T cells.
- The study found that there is increased expression of the microRNA miR-210 in CD4(+) T cells from PV patients, which negatively affects the expression of FOXP3, a key gene for regulatory T cell function.
- Inhibiting miR-210 can enhance FOXP3 expression and potentially restore normal immune function in T cells from PV patients, suggesting miR-210 plays a crucial role in the disease's immunity-related issues.
Objectives: To investigate alterations in histone modifications in B cells and their role in the pathogenesis of systemic sclerosis (SSc).
Methods: Global histone H3/H4 acetylation and H3K4/H3K9 methylation in B cells of SSc were tested by EpiQuik™ assay kits. Related histone modifier enzymes were measured by RT-PCR and Western blot.
Total glucosides of paeony (TGP), an active compound extracted from Paeony root, has been used in therapy for autoimmune diseases. However the molecular mechanism of TGP in the prevention of autoimmune response remains unclear. In this study, we found that TGP treatment significantly increased the percentage and number of Treg cells in lupus CD4(+) T cells.
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