Publications by authors named "Gong-Li Ma"
The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) is associated with development of type II diabetes mellitus (T2DM). (-)-Epigallocatechin gallate (EGCG) can bind amyloid proteins to inhibit the fibrillation of these proteins. However, the mechanic detail of EGCG inhibiting amyloid formation is still unclear at the molecular level.
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- The study investigates how aluminum (Al(III)) affects the fibrillation of a protein linked to type II diabetes (hIAPP) and how the compound (-)-epigallocatechin gallate (EGCG) interacts with both aluminum and hIAPP.
- EGCG can inhibit normal fibrillation of hIAPP, potentially leading to less toxic aggregates, while Al(III) promotes its fibrillation.
- The combination of Al(III) and EGCG was found to be more effective in inhibiting hIAPP fibrillation than EGCG alone, suggesting a potential pathway for drug development in treating type II diabetes.