Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors.

Background: Gastrointestinal stromal tumors (GISTs) are typical gastrointestinal tract neoplasms. Imatinib is the first-line therapy for GIST patients. Drug resistance limits the long-term effectiveness of imatinib.

Vacuum sealing drainage to treat Fournier's gangrene.

Background: Vacuum sealing drainage (VSD) is widely applied in complex wound repair. We aimed to compare traditional debridement and drainage and VSD in treating Fournier's gangrene (FG).

Methods: Data of patients surgically treated for FG were retrospectively analyzed.

Promotes the Metastasis of Gastric Cancer, Possibly by Inducing EMT.

Aim: To investigate the function of Aurora kinase B (AURKB) in gastric cancer (GC).

Methods: Immunohistochemistry was used to assay the expression of AURKB in 50 pairs of GC and adjacent tissues, and qRT-PCR was conducted to test expression in normal gastric epithelial and GC cell lines. Two segments of small interference RNAs (siRNAs) targeting were synthesized and inserted into GV248 lentivirus vector.