Talar Dome Investigation and Talocrural Joint Axis Analysis Based on Three-Dimensional (3D) Models: Implications for Prosthetic Design.

Ankle joint kinematics is mainly stabilized by the morphology of the talar dome and the articular surface of tibiofibular mortise as well as the medial and lateral ligament complexes. Because of this the bicondylar geometry of talus dome is believed to be crucial for ankle implant design. However, little data exist describing the precise anatomy of the talar dome and the talocrural joint axis.

Gender Variation in the Shape of Superior Talar Dome: A Cadaver Measurement Based on Chinese Population.

Understanding the shape of superior talar dome is essential for a better size compatibility between talar component of ankle implant and bone. The purpose of this study was to determine whether there were gender variations in (1) width (TW) and length (TL) of talus, as well as anterior width (DAW), middle width (DMW), posterior width (DPW), and length (DL) of superior talar dome; (2) differences between the DAW, DMW, and DPW; (3) the ratios between these parameters. Fifty-one cadaveric ankle specimens were included.

, a crucial target of miR-410, functions as a potential oncogene in osteosarcoma.

Purpose: Mounting evidence highlights the essential role of in tumor initiation and malignant progression in several cancers; however, the function of in osteosarcoma (OS) remains unknown. In this study, we aim to investigate the role of and reveal its regulation by deregulated miRNAs in OS.

Materials And Methods: The expression profiles of were examined by immunohistochemistry, Western blotting, and qRT-PCR.