Intrinsic Breakdown Strength: Theoretical Derivation and First-Principles Calculations.

Intrinsic breakdown strength (F_{bd}), as the theoretical upper limit of electric field strength that a material can sustain, plays important roles in determining dielectric and safety performance. The well accepted concept is that a larger band gap (E_{g}) often leads to a larger intrinsic breakdown strength. In this work, we analytically derive a simplified model of F_{bd}, showing a linear relationship between F_{bd} and the maximum electron density of states (DOS_{max}) within the energy range spanning from the conduction band minimum (CBM) to CBM+E_{g}.

Challenges in diagnosing and managing sarcomatoid urothelial carcinoma of the renal pelvis: a case report.

Sarcomatoid urothelial carcinoma of the renal pelvis is an extremely rare malignant tumor with a high risk of recurrence and metastasis and a poor prognosis. This case reports a 61-year-old male patient with renal pelvic sarcomatoid urothelial carcinoma who developed extensive lymph node metastasis 26 days after posterior laparoscopic radical nephrectomy for renal carcinoma, and the patient died on the 45th postoperative day, with the cause of death being advanced malignancy of the tumor. This case highlights the rapid progression of sarcomatoid urothelial carcinoma, and sarcomatoid variants should be identified as early as possible, with active multidisciplinary adjuvant therapy and closer follow-up when feasible.

-a novel zinc finger transcription factor involved in azole resistance.

Elucidating the mechanisms underlying antifungal resistance in , discovering new antifungal targets, and developing drugs to inhibit resistance are the key approaches to treating infections. Here, we investigated the function of (AFUA_1G03800), a gene encoding a C6 transcription factor. Homologous recombination replacement technology was employed to construct knockout and revertant strains.

MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2.

Objective: To investigate the role and underlying mechanism of Methyl-CpG binding domain protein 2 (MBD2) in the pathogenesis of acute respiratory distress syndrome (ARDS)-related pulmonary fibrosis.

Methods: Murine models for ARDS-related pulmonary fibrosis were established in wildtype or MBD2 knockout mice, expressions of MBD2 were determined with immunohistochemistry (IHC), immunofluorescence, and western blot. Epithelial-to-mesenchymal transition (EMT) was detected with determined with decreased expression of E-cadherin and increased expressions of N-cadherin, Vimentin, and α-smooth muscle actin (α-SMA).

Preparation of mitochondrial targeted near-infrared ratio fluorescent probe and its dual response detection for viscosity and ONOO and cell imaging.

The changes in viscosity and the concentration of ONOO in mitochondria can effectively reflect the physiological and pathological status of cells. Therefore, the development of effective fluorescent probes for the sensing of viscosity and the concentration of ONOO in mitochondria has great significance. In this article, a mitochondrial targeted fluorescent probe named Mito-RP was synthesized for the dual responsive sensing of viscosity and ONOO by introducing pyridine ring and phenylboronic acid ester structure into 4-dimethylamino-cinnamaldehyde with long conjugated chain structure as the parent material.

TOUSLED KINASE INTERACTING PROTEIN 1 (TKI1) interacts with SIN3-LIKES (SNLs) to promote flowering in Arabidopsis.

TOUSLED KINASE INTERACTING PROTEIN 1 (TKI1) is a SANT/Myb domain-containing protein, which binds DNA and may function as a transcription factor, and is characterized as an interacting protein with TOUSLED (TSL) in Arabidopsis. However, it remains largely unknown what biological functions of TKI1 for few reports about TKI1 in the literature. Here we first identified that TKI1 interacts with SIN3-LIKEs (SNLs) and the responsible interaction domains are the C-terminal domain of TKI1 and the PAH (Paired Amphipathic Helix) domains of SNLs respectively in yeast.

Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma: The DIPPER Randomized Clinical Trial.

Importance: Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role in locoregionally advanced NPC is unclear.

Objective: To evaluate the efficacy and safety of adjuvant camrelizumab for patients with locoregionally advanced NPC.

Effect of active immunization with recombinant GnRH6-kisspeptin fusion protein on reproductive function in male rats.

Immunological castration can be an alternative to traditional surgical castration. The active immunization against GnRH or kisspeptin has a castrating effect. To date, the fusion protein vaccine of combination with GnRH and kisspeptin have not been studied.

Novel One-Step Total Synthesis of -Dehydroosthol and Citrubuntin.

Efficient and simple syntheses of -dehydroosthol and citrubuntin were achieved in a single step by implementing a protecting-group-free, redox-neutral strategy that utilized readily available starting materials. In this approach, a practical one-pot (domino) Heck/dehydration reaction was carried out utilizing less reactive bromocoumarin, resulting in excellent stereoselectivity and atomic economy. Through the implementation of this new, efficient, and scalable synthesis method, the formal synthesis of a series of novel meroterpenoid natural products was successfully achieved.

Roles of flgJ in biofilm formation of Vibrio alginolyticus.

Aim: This study aimed to investigate the role of two flgJ genes in flagellar assembly and biofilm regulation in Vibrio alginolyticus.

Methods And Results: To investigate the functions of the flgJ, overexpression and gene knockout techniques were employed. Overexpression of flgJ1 enhanced the strain's growth capacity, leading to a rapid bacterial concentration that initiated biofilm formation.

A Novel Coating-Extrusion Method Enabled, High Energy, Power Density, and Scalable Production in Monolithically Integrated Energy Storage Fibers.

The rise of wearable electronics demands flexible energy storage solutions like flexible fiber energy storage devices (FESDs), known for their flexibility and portability. However, it remains difficult for existing fabrication methods (typically, finite-coating, thermal-drawing, and solution-extrusion) to simultaneously achieve desirable electrochemical performances and fast production of FESDs. Here, a new scalable coating-extrusion method is developed, utilizing a novel extruded spinneret with tapered apertures to create dual pressure zones.

Identifying palliative home care needs of patients with advanced cancer: a cross-sectional study.

Background: Home-based palliative care is an ideal model for providing continuous, effective, and timely care at the patient's home. However, the timely recognition of palliative home care needs remains a clinical challenge, and few studies have described the characteristics of palliative care needs and quality of life at home.

Objectives: To identify the palliative home care needs of patients with advanced cancer and explore the influencing factors in addressing these needs.

Targeting TRPV1 channels in desensitized neural afferent pathways may help mitigate pain and lower urinary tract symptoms caused by prostatitis.

Chronic prostatitis/chronic pelvic pain syndrome (CPPS/CP) is a prevalent urinary disorder primarily characterized by pelvic pain and discomfort, bladder dysfunction, and sexual dysfunction. Currently, there is no effective method to alleviate the pain and lower urinary tract symptoms associated with chronic prostatitis. Resiniferatoxin (RTX), a highly potent TRPV1 receptor agonist, functions as a molecular analgesic by desensitizing TRPV1-expressing nerves.

An experimental and theoretical study of the photoionization properties of polysulfanes (HS, = 2-4).

We prepared polysulfanes (HS, = 2 to 4) photon irradiation of hydrogen sulfide (HS) ices and measured their photoionization efficiency spectra. The ionization energies of HS, HS and HS were determined to be 9.08 ± 0.

Adherence to phase I cardiac rehabilitation in post-PCI patients: a latent class analysis.

Background: Coronary heart disease seriously jeopardizes human health and has become a principal public health problem of global concern. While percutaneous coronary intervention (PCI) repairs narrowed arteries and extends patients' lives, cardiac rehabilitation offers additional benefits post-PCI. Numerous previous studies have shown that cardiac rehabilitation can inhibit the progression of atherosclerotic plaques in patients after coronary intervention, effectively controlling patients' clinical symptoms and improving their quality of life.

[The role of microglia activated by the deletion of immune checkpoint receptor CD200R1 gene in a mouse model of Parkinson's disease].

The study aimed to investigate the effect of the CD200R1 gene deletion on microglia activation and nigrostriatal dopamine neuron loss in the Parkinson's disease (PD) process. The CRISPR-Cas9 technology was applied to construct the CD200R1 mice. The primary microglia cells of wild-type and CD200R1 mice were cultured and treated with bacterial lipopolysaccharide (LPS).

Enhancement of Impact Resistance and Shock Wave Protection in Strain Rate-Reinforced Leather Composite.

This work develops the Leather/SSG composite with a laminated structure that consists of flexible leather and rate-dependent shear stiffening gel (SSG), which exhibits superior impact resistance and shock wave protection performance. The SSG is tightly bound to the leather fiber network through hydrogen bonding interactions between the interfaces. Owing to the phase change energy absorption effect of SSG and the synergizing impact force dispersion along the disordered fibers, the Leather/SSG can effectively alleviate the impact force (52%) and shows high energy absorption (0.

TopoQA: a topological deep learning-based approach for protein complex structure interface quality assessment.

Even with the significant advances of AlphaFold-Multimer (AF-Multimer) and AlphaFold3 (AF3) in protein complex structure prediction, their accuracy is still not comparable with monomer structure prediction. Efficient and effective quality assessment (QA) or estimation of model accuracy models that can evaluate the quality of the predicted protein-complexes without knowing their native structures are of key importance for protein structure generation and model selection. In this paper, we leverage persistent homology (PH) to capture the atomic-level topological information around residues and design a topological deep learning-based QA method, TopoQA, to assess the accuracy of protein complex interfaces.

Facile minocycline deployment in gingiva using a dissolvable microneedle patch for the adjunctive treatment of periodontal disease.

Minocycline is a commonly used drug for adjunctive therapy in periodontal disease. However, the current mainstream local medications primarily rely on intra-pocket administration, which, while avoiding the side effects of traditional systemic drugs, presents challenges such as inconvenience, discomfort, and the need for professional assistance, thus affecting patient compliance. Herein, we introduce a minocycline-loaded dissolvable microneedle (Mino-DMN) patch that allows for local and efficient delivery of minocycline to gingiva for the treatment of periodontitis.

Mobile Oxygen Capture Enhances Photothermal Stability of Perovskite Solar Cells Under ISOS Protocols.

Stability testing protocols from the International Summit on Organic and Hybrid Solar Cell Stability (ISOS) are essential for standardizing studies on the photothermally operational stability of perovskite solar cells (PSCs). Under photothermal conditions, the migration of oxygen from SnO layer induces cationic dehydrogenation at the A-site of the perovskite, accelerating degradation to PbI. This leads to the formation of photoinduced I and Pb defects, significantly compromising long-term stability.

Microplastics in groundwater: environmental fate and possible interactions with coexisting contaminants.

Microplastics (MPs) are emerging environmental pollutants which represent a serious threat to ecosystems and human health and have received significant attention from the global community. Currently, a growing number of studies have found the presence of MPs in groundwater. This study exhaustively reviewed varying degrees of recent publications in Web of Science database and investigated the characteristics of MPs (concentration, types, sizes and shapes) in groundwater ecosystems, their migration characteristics, and interactions with co-occurring contaminants.

Skin lesion segmentation with a multiscale input fusion U-Net incorporating Res2-SE and pyramid dilated convolution.

Skin lesion segmentation is crucial for identifying and diagnosing skin diseases. Accurate segmentation aids in identifying and localizing diseases, monitoring morphological changes, and extracting features for further diagnosis, especially in the early detection of skin cancer. This task is challenging due to the irregularity of skin lesions in dermatoscopic images, significant color variations, boundary blurring, and other complexities.

Effects of PAHs on nitrogen uptake by phytoplankton species: Implications for environmental risk assessment of micropollutants and algal bloom formation.

Polycyclic aromatic hydrocarbons (PAHs) are of great concern because they threaten primary productivity, but their specific effects on ecosystem functioning are scarce, hindering a comprehensive understanding of their ecological risks, especially in eutrophic waters. The present study was conducted by adding PAHs to four marine phytoplankton species and showed that naphthalene (Nap) and phenanthrene (Phe) induced both stimulatory and inhibitory effects (>50 %) on urea and NO uptake by phytoplankton species. In addition, the apparent stimulative effects (>50 %) for NH were also observed.