PagSND1-B1 Regulates Wood Formation by Influencing Phosphorus Absorption and Distribution in Poplar.

In natural environments, the growth and development of trees are continuously affected by phosphorus (P) starvation stress. However, the mechanisms through which trees balance stem growth and P distribution remain unknown. This study found that in the woody model species poplar, the P loss in stems is more severe than that in roots and leaves under P starvation conditions, thereby inhibiting stem development and reducing the expression of numerous genes related to wood formation, including PagSND1-B1.

Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans.

Clopidogrel, an anti-platelet drug, is used to prevent thrombosis after percutaneous coronary intervention. Clopidogrel resistance results in recurring ischemic events, with African Americans (AA) suffering disproportionately. The aim of this study was to discover novel biomarkers of clopidogrel resistance in African Americans using genome and transcriptome data.

LiF Artifacts in XPS Analysis of the SEI for Lithium Metal Batteries.

The solid electrolyte interphase (SEI) is considered to be the key to the performance of lithium metal batteries (LMBs). The analysis of the SEI and cathode electrolyte interphase (CEI) composition (especially F 1s spectra) by X-ray photoelectron spectroscopy (XPS) has become a consensus among researchers. However, the surface-sensitive XPS characterization is susceptible to LiF artifacts due to several factors, leading to the overexaggerated role of LiF in the analysis of the SEI and CEI.

Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors.

Background: Bone-invasive Pituitary Neuroendocrine Tumors (BI PitNETs) epitomize an aggressive subtype of pituitary tumors characterized by bone invasion, culminating in extensive skull base bone destruction and fragmentation. This infiltration poses a significant surgical risk due to potential damage to vital nerves and arteries. However, the mechanisms underlying bone invasion caused by PitNETs remain elusive, and effective interventions for PitNET-induced bone invasion are lacking in clinical practice.

Comparative study of the toxicity responses of Vallisneria natans and Pistia stratiotes to sulfadiazine under different planting methods.

Sulfonamides are receiving increased attention due to their persistence in the environment and potential ecological risks. However, there are currently relatively few studies on the toxicity response of aquatic plants grown under the single and mixed planting methods to sulfadiazine (SD). This study investigated the response of the Vallisneria natans (Lour.

Analysis of cervical and breast cancer screening behavior and its influencing factors among urban and rural women in Beijing.

Objective: To clarify the screening behavior and influencing factors of females with breast cancer and cervical cancer in suburban areas and to provide a scientific basis for the subsequent implementation of targeted health education, intervention measures and the formulation of relevant policies.

Methods: This study used a multi-stage stratified random sampling method to select 4, 000 women in urban and rural areas of Beijing to analyze their behavior, basic situation, and influencing factors regarding cervical and breast cancer screening.

Results: The sample size of the final included valid analysis was 3861 people, and the screening rate was 27.

Shouhui Tongbian Capsule ameliorates obesity by enhancing energy consumption and promoting lipolysis via cAMP-PKA pathway.

Background: The prevalence of obesity and its associated diseases has sharply increased, becoming a global health issue. White adipose tissue (WAT), responsible for lipid storage via hyperplasia and hypertrophy, and brown adipose tissue (BAT), which facilitates energy dissipation, have increasingly been recognized as critical regulators of weight loss. Shouhui Tongbian Capsule (SHTB) has traditionally been used for detoxification, weight loss, and lipid reduction, and clinical evidence supports its use for relieving constipation.

Pyridine polymer tubular structures connected with polyoxometalates as bifunctional electrocatalysts for water splitting.

In this work, we successfully prepared four POM-based organic-inorganic hybrids, namely, [(CHN)(CHN)][PMoO] (1), [(CHN)(CHN)][PMoO] (2), [(CHN)][PMoO]·4HO (3), and [(CHN)][PMoO] (4) (where CHN = pyridine, CHN = pyrazine, CHN = 2,7-diamino-1,3,4,6,8,9-hexaazaspiro[4.4] nonane, and CHN = 3-amino-1,2,4-triazole), using a hydrothermal method. Compounds 1 and 2 exhibited a lamellar three-dimensional structure.

Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis.

Background: To elucidate the genetic and molecular mechanisms underlying psoriasis by employing an integrative multi-omics approach, using summary-data-based Mendelian randomization (SMR) to infer causal relationships among DNA methylation, gene expression, and protein levels in relation to psoriasis risk.

Methods: We conducted SMR analyses integrating genome-wide association study (GWAS) summary statistics with methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data. Publicly available datasets were utilized, including psoriasis GWAS data from the European Molecular Biology Laboratory-European Bioinformatics Institute and the UK Biobank.

Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases.

Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which have become the focus of research. Stimulus-responsive nanodrug delivery systems (SRDDS) stand out as a sophisticated class of nanocarriers that can release drugs in response to environmental cues.

Thermal- and Rate-Regulated Fast Switchable Adhesion within Glass Transition Zone of an Epoxy Polymer.

Thermoresponsive shape memory polymer (SMP) adhesives have demonstrated a high adhesion strength and large switching ratios on different substrates. However, a long response time to switch adhesion on or off is generally encountered. This study provides a fast adhesion switching method based on the temperature and rate dependence of adhesion within the glass-transition zone of an epoxy polymer.

Aggressive characteristics of tumor deposits in colorectal cancer highlight the need for staging refinement in patients with 0-3 metastatic lymph nodes.

Accurate staging is essential for the optimal management of patients with colorectal cancer (CRC). The role of tumor deposits (TDs) in CRC staging has been contentious due to a lack of comprehensive understanding of their clinical and biological traits. In this retrospective study, we analyzed large data from 5718 CRC patients diagnosed between 2011 and 2022, ensuring rigorous data collection and long-term follow-up.

Dearomatizing Photocyclization and Oxidative Aromatization: Constructing Polycyclic Arenes from Styrenes.

The direct construction of polycyclic arenes through ring formation using simple building blocks is highly appealing but remains challenging in organic chemistry. In this study, we introduce an efficient cascade reaction that combines dearomatizing photocyclization with oxidative aromatization, driven by organophotocatalysis. Conducted under mild, transition-metal-free conditions, this reaction seamlessly converts styrene derivatives into a diverse array of functionalized polycyclic aromatic compounds with good yields and regioselectivity.

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing.

Aberrant sialylated glycosylation in the tumor microenvironment is a novel immune suppression pathway, which has garnered significant attention as a targetable glycoimmune checkpoint for cancer immunotherapy to address the dilemma of existing therapies. However, rational drug design and in-depth mechanistic studies are urgently required for tumor sialic acid to become valuable glycoimmune targets. In this study, we explored the positive correlation of PD-L1 and sialyltransferase expression in clinical colorectal cancer tissues and identified their mutual regulation effects in macrophages.

Spatial epidemiological analysis based on township scale and analysis of influencing factors of pulmonary tuberculosis cure of Changshu city from 2015 to 2022.

Objective: This study aimed to enhance the prevention and control of pulmonary tuberculosis (PTB) and provide more effective and accurate methods in Changshu City.

Methods: The PTB patients' information came from the China Information System for Disease Control and Prevention (CISDCP). The demographic data for Changshu city and towns came from the Suzhou Statistical Yearbook and the LandScan platform.

Effects of tannic acid on growth performance, intestinal health, and tolerance in broiler chickens.

This study investigated the optimal tannic acid dosage and assessed tolerance levels in broiler chickens. In experiment 1, 525 broilers were randomly divided into 5 treatment groups, the control group (CON group) and groups TA1 to TA4, corresponding to treatments of 0.025, 0.

Ordered Interfacial Water Generated at Poly(ionic liquid) Membrane Surface Imparts Ultrafast Water Transport and Superoleophobicity.

Achieving ultrahigh permeance and superoleophobicity is crucial for membrane application. Here, we demonstrated that a poly(ionic liquid)/PES hydrogel membrane can achieve dual goals. The high polarity of the ionic liquids induces the water molecules on the membrane surface to be arranged more ordered, as verified by molecular dynamics (MD) simulation and advanced femtosecond sum frequency generation (SFG) vibrational spectroscopy.

Aligned membranes regulate wound healing via MMP12 secreted by macrophages.

Aligned electrospinning membranes (Align) have demonstrated the potential to enhance wound healing by establishing a regenerative microenvironment surrounding the wound; However, the precise mechanism underlying its facilitation of healing remains unclear. To elucidate aligned electrospun fiber membrane's role in accelerating wound healing and improving its quality, we conducted a comprehensive analysis. Firstly, in vivo experiments confirmed that Align promotes wound healing.

Does season regulate heterochronous leaf growth? Mechanisms of petiole-lamina trade-offs in broad-leaved woody plants of the Tianshan Mountains.

As the core of leaf functional traits, the trade-off relationship between the petiole and lamina expresses the plant's adaptability to the environment in terms of support structure and photosynthesis. We investigated the proportions of allometric growth in the relationship between the petiole and the lamina of broadleaf woody plants in temperate highland Tianshan Mountains montane forests through three dimensions (length, area, and mass), including the length of the lamina (LL) and the length of the petiole (PL), and the area of the lamina (LA) and petiole cross sectional area (PCA) versus the mass of the lamina (LM) and the mass of the petiole (PM), as well as exploring the characteristics of the variance in response to seasonal changes. We found that the functional traits in all three dimensions showed a clear convergent evolution as the seasons progressed, that is, a "seasonal effect" of increasing and then decreasing.

Multi-effect synergistic induction of unsaturated MnO on sandy sediment for enhanced manganese adsorption and byproduct resource recovery in solar evaporation.

The efficient removal of Mn(II) from wastewater is crucial for safeguarding water quality, yet existing adsorbents face significant challenges, including high costs, poor resistance to ionic interference, and scalability limitations. This study addresses these challenges by utilizing abundant natural sandy sediment (SS) as a substrate to load unsaturated MnO via in-situ oxidation, creating a novel adsorbent (MOSS). MOSS exhibits a remarkable Mn(II) adsorption capacity of 1.

Epigenetics in the modern era of crop improvements.

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades, our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits.

Time-varying 3D optical torque via a single beam.

The spin angular momentum (SAM) plays a significant role in light-matter interactions. It is well known that light carrying SAM can exert optical torques on micro-objects and drive rotations, but 3D rotation around an arbitrary axis remains challenging. Here, we demonstrate full control of the 3D optical torque acting on a trapped microparticle by tailoring the vectorial SAM transfer.

Calcified chondroid mesenchymal neoplasm: a clinicopathological and molecular analysis.

Aims: Calcified chondroid mesenchymal neoplasm (CCMN) is a recently identified category of soft tissue neoplasms defined by cartilage or cartilaginous matrix formation and gene fusions. Its rarity and similarities to other soft tissue tumours pose diagnostic challenges. This study aims to deepen understanding of CCMN, highlighting molecular pathology's role in diagnosis to reduce misdiagnosis, overdiagnosis and overtreatment.