Computational analysis of super-resolved in situ sequencing data reveals genes modified by immune-tumor contact events.

Cancer cells can manipulate immune cells and escape from the immune system response. Quantifying the molecular changes that occur when an immune cell touches a tumor cell can increase our understanding of the underlying mechanisms. Recently, it became possible to perform such measurements in situ-for example, using expansion sequencing, which enabled in situ sequencing of genes with super-resolution.

A flexible employee recruitment and compensation model: A bi-level optimization approach.

The growing practice of flexible work following the COVID-19 pandemic is likely to have a significant impact on management and human resource (HR) practices. In this paper, we propose a novel bi-level mathematical programming model that can serve as a decision support tool for firms in real-life settings to improve recruitment and compensation decisions associated with hybrid and flexible work plans. The proposed model is composed of two levels: the first level reflects the company's goal of maximizing profitability by offering competitive salaries to candidates.

Ordinal Decision-Tree-Based Ensemble Approaches: The Case of Controlling the Daily Local Growth Rate of the COVID-19 Epidemic.

In this research, we develop ordinal decision-tree-based ensemble approaches in which an objective-based information gain measure is used to select the classifying attributes. We demonstrate the applicability of the approaches using AdaBoost and random forest algorithms for the task of classifying the regional daily growth factor of the spread of an epidemic based on a variety of explanatory factors. In such an application, some of the potential classification errors could have critical consequences.

An Objective-Based Entropy Approach for Interpretable Decision Tree Models in Support of Human Resource Management: The Case of Absenteeism at Work.

The negative impact of absenteeism on organizations' productivity and profitability is well established. To decrease absenteeism, it is imperative to understand its underlying causes and to identify susceptible employee subgroups. Most research studies apply hypotheses testing and regression models to identify features that are correlated with absenteeism-typically, these models are limited to finding simple correlations.

Employees recruitment: A prescriptive analytics approach via machine learning and mathematical programming.

In this paper, we propose a comprehensive analytics framework that can serve as a decision support tool for HR recruiters in real-world settings in order to improve hiring and placement decisions. The proposed framework follows two main phases: a local prediction scheme for recruitments' success at the level of a single job placement, and a mathematical model that provides a global recruitment optimization scheme for the organization, taking into account multilevel considerations. In the first phase, a key property of the proposed prediction approach is the interpretability of the machine learning (ML) model, which in this case is obtained by applying the Variable-Order Bayesian Network (VOBN) model to the recruitment data.