Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL.

The t(1;19) translocation, encoding the oncogenic fusion protein E2A (TCF3)-PBX1, is involved in acute lymphoblastic leukemia (ALL) and associated with a pre-B-cell receptor (preBCR+) phenotype. Relapse in patients with E2A-PBX1+ ALL frequently occurs in the central nervous system (CNS). Therefore, there is a medical need for the identification of CNS active regimens for the treatment of E2A-PBX1+/preBCR+ ALL.

Large-Scale Traveling Atmospheric and Ionospheric Disturbances Observed in GUVI With Multi-Instrument Validations.

This study presents multi-instrument observations of persistent large-scale traveling ionosphere/atmospheric disturbances (LSTIDs/LSTADs) observed during moderately increased auroral electrojet activity and a sudden stratospheric warming in the polar winter hemisphere. The Global Ultraviolet Imager (GUVI), Gravity field and steady-state Ocean Circulation Explorer, Scanning Doppler Imaging Fabry-Perot Interferometers, and the Poker Flat Incoherent Scatter Radar are used to demonstrate the presence of LSTIDs/LSTADs between 19 UT and 5 UT on 18-19 January 2013 over the Alaska region down to lower midlatitudes. This study showcases the first use of GUVI for the study of LSTADs.

Pronounced Suppression and X-Pattern Merging of Equatorial Ionization Anomalies After the 2022 Tonga Volcano Eruption.

Following the 2022 Tonga Volcano eruption, dramatic suppression and deformation of the equatorial ionization anomaly (EIA) crests occurred in the American sector ∼14,000 km away from the epicenter. The EIA crests variations and associated ionosphere-thermosphere disturbances were investigated using Global Navigation Satellite System total electron content data, Global-scale Observations of the Limb and Disk ultraviolet images, Ionospheric Connection Explorer wind data, and ionosonde observations. The main results are as follows: (a) Following the eastward passage of expected eruption-induced atmospheric disturbances, daytime EIA crests, especially the southern one, showed severe suppression of more than 10 TEC Unit and collapsed equatorward over 10° latitudes, forming a single band of enhanced density near the geomagnetic equator around 14-17 UT, (b) Evening EIA crests experienced a drastic deformation around 22 UT, forming a unique X-pattern in a limited longitudinal area between 20 and 40°W.

Night-Time Ionospheric Localized Enhancements (NILE) Observed in North America Following Geomagnetic Disturbances.

The Ionospheric Data Assimilation Four-Dimensional (IDA4D) technique has been coupled to Sami3, which is another model of the ionosphere (SAMI3). In this application, ground-based and space-based GPS total electron content (TEC) data have been assimilated into SAMI3, while in-situ electron densities, autoscaled ionosonde NmF2, and reference GPS stations have been used for validation. IDA4D/SAMI3 shows that night-time ionospheric localized enhancements (NILE) are formed following geomagnetic storms in November 2003 and August 2018.

Impact of September 2019 Antarctic Sudden Stratospheric Warming on Mid-Latitude Ionosphere and Thermosphere Over North America and Europe.

Limited observational evidence indicates that ionospheric changes caused by Arctic sudden stratospheric warmings (SSWs) occur at middle latitudes in the Southern Hemisphere. However, it is not known if a similar interhemispheric linkage is produced by Antarctic SSWs. Here we examine thermospheric and ionospheric anomalies observed in September 2019 at middle latitudes in the Northern Hemisphere.

Rational Design Yields Molecular Insights on Leaf-Binding of Anchor Peptides.

In times of a constantly growing world population and increasing demand for food, sustainable agriculture is crucial. The rainfastness of plant protection agents is of pivotal importance to reduce the amount of applied nutrients, herbicides, and fungicides. As a result of protective agent wash-off, plant protection is lost, and soils and groundwater are severely polluted.

Effect of the type of reducing agents of silver ions in interpolyelectrolyte-metal complexes on the structure, morphology and properties of silver-containing nanocomposites.

The objective of this work is to study the peculiarities of structural organization, morphology, thermomechanical, electrical and antimicrobial properties of nanocomposites based on pectin-polyethyleneimine interpolyelectrolyte complexes and silver nanoparticles in dependence on the type of reducing agent being applied for chemical reduction of silver ions in the interpolyelectrolyte-metal complexes. The average size of Ag nanoparticles is shown to be increased with decreasing of the activity of reducing agent (E) and equals to 3.8 nm, 4.

[Therapeutic effect of gastrozolum in stomach ulcers].

Gastrozolum is the proprietary name of a drug made in Saint Petersburg. Its international nonproprietary name is Omeprazole. The absorption rate is not related to food.

[The new potentials of magneto-laser therapy and electrostimulation in children with cleft palate and upper lip].

The paper presents rationale for design of new procedures of physiotherapy in children with expanded palate and upper lip; morphofunctional features of prenatal and early postnatal formation of central nervous system; a multilayer technique of magneto-laser radiation to the projection of the anterior central gyrus and the technique of electrostimulation by the system of the wink reflex which can influence central mechanisms of regulation and adaptation before and early after uranoplasty and cheiloplasty.

[The status of the immunity system in diphtheria].

The complex study of cell-mediated and humoral immunity characteristics, as well as nonspecific protective factors, in 30 diphtheria patients, 9 clinically healthy carriers and 54 healthy subjects was carried out. In healthy immunized subjects normal characteristics of all elements of immunity were observed in combination with high titers of antitoxins and sensitization of lymphocytes to diphtheria toxoid. In healthy carriers the presence of cell-mediated and humoral immunity to diphtheria was associated with disturbances of the metabolic activity of phagocytes and a decrease in the proliferation of lymphocytes in response to the mitogen.

[Physical factors in the combined rehabilitation of children with a congenital cleft of the upper lip].

A total of 551 children with cleft lips and 136 children with secondary deformations of the upper lip and nose were followed up after cheiloplasty. Electrostimulation of the upper lip, total UV exposure, humisol and pelloidine electrophoresis, and total massage before cheiloplasty decreased the incidence of general and local postoperative complications. Reconstructive cheiloplasty was preceded by lidase or iodine ultraphonophoresis or electrostimulation of the perioral muscles.

[Immune system in residents of territories contaminated with radionuclides after Chernobyl accident].

Aim: Study of the immunity and nonspecific defense factors in subjects living at a territory contaminated with radionuclides at a density of 1-5 Ci/km2 after the Chernobyl accident.

Materials And Methods: A total of 144 subjects aged 18 to 82 years living in the Sasovo region of the Ryazan district were examined. Three groups were distinguished with different density of contamination: 1) n = 54, 1-5 Ci/km2; 2) n = 36, conditionally pure territory; and 3) n = 54, living at the interface of the two territories.

[Hemodynamic disorders in acute intestinal obstruction in the early postoperative period and their correction].

Eight indices of hemodynamics and microcirculation in 50 patients with acute ileus (AI) at the early postoperative period were studied. The significant deviation of all (except arterial pressure) indices, especially those characterising the disorders in microcirculation were revealed. They were the most pronounced in patients with AI of tumour nature.

[Myelochondroplasty of bone cavities and defects of the jaw bones].

A new transplant is designed which consists of an autologous vital bone marrow and dispersed lyophylized allogenic rib cartilage. With postsurgical cavities filled with this transplant, the regeneration of osteal tissue was clearly accelerated in the defect site. This reduced both the rehabilitation terms and complication incidence and improved the cosmetic effect in patients with extensive residual osteal cavities formed during pathological tissues extirpation.

[Ambiphyra ameiuri--a dangerous parasite of Ictalurus punctatus Rafinesque].

A description of the ectoparasitic ciliate of the channel catfish Ictalurus punctatus, Ambiphrya ameiuri, is given. Various medicinal preparations were tested in order to control A. ameiuri.

[Effect of jogging on lipid peroxidation, blood coagulation and anti-aggregation properties of the vascular wall].

In a group of volunteers of different age, engaged in health-improving running for various time, a level of antioxidants and a capacity of vascular wall to synthesize the antiaggregating substances were increased as well as blood coagulation parameters were decreased. These alterations were especially important for men because of the favourable effect of the running on blood rheology and microcirculation as well as on metabolism of cell and tissues.