[Clinical and laboratory presentation of the influenza A (H1N1pdm 2009) in children and adults during the period of 2009-2013 in St. Petersburg].

Comparative analysis of the clinical laboratory data from 419 children and 468 adults hospitalized during the pandemic of A (H1N1pdm 2009) and pre- and post-pandemic periods (2010-2013) showed that the clinical presentation of the pandemic influenza in patients of all ages is generally typical for influenza, and its character is determined by the degree of involvement of lungs in the process. Besides, the incidence of pneumonia in adults is statistically significantly higher than in children. During all compared periods hyperthermia (≥ 39 degrees C), hemorrhagic and dyspeptic syndrome were observed.

Recognition of stable distribution with Lévy index α close to 2.

We address the problem of recognizing α-stable Lévy distribution with Lévy index close to 2 from experimental data. We are interested in the case when the sample size of available data is not large, thus the power law asymptotics of the distribution is not clearly detectable, and the shape of the empirical probability density function is close to a Gaussian. We propose a testing procedure combining a simple visual test based on empirical fourth moment with the Anderson-Darling and Jarque-Bera statistical tests and we check the efficiency of the method on simulated data.

[Effect of losartan, lisinopril and their combination on hemodynamics and morphofunctional parameters of the heart in patients with chronic cardiac failure].

The aim of the study was to evaluate effects of losartan receptor I antagonist (AT) and/or angiotensin converting enzyme inhibitor (iACE) on clinical manifestations of the disease, hemodynamic characteristics, morphofunctional heart parameters in patients with chronic cardiac insufficiency (CHI) complicating coronary heart disease (CHD). A total of 60 patients aged 48-72 (mean 62 +/- 8.4) years with persistent symptoms of functional class II-IV CHI and left ventricular (LV) fraction = < 45% complicating CHD.

Kramers-like escape driven by fractional Gaussian noise.

We investigate the escape from a potential well of a test particle driven by fractional Gaussian noise with Hurst exponent 0 View Article and Find Full Text PDF

[Clinical trial of safety and immunogenicity of new influenza vaccine Grifor in children].

Aim: Assessment of reactogenicity, safety and immunogenicity after single intramuscular immunization of children with Grifor vaccine.

Materials And Methods: Reactogenicity, safety, and immunogenicity of Grifor vaccine compared with Vaxigrip vaccine was evaluated during phase III clinical trial in the Institute of Influenza. Thirty-six children aged 12 - 17 years, divided on 2 groups, participated in single blind comparative prospective randomized trial.

Generalized fractional diffusion equations for accelerating subdiffusion and truncated Lévy flights.

Fractional diffusion equations are widely used to describe anomalous diffusion processes where the characteristic displacement scales as a power of time. For processes lacking such scaling the corresponding description may be given by diffusion equations with fractional derivatives of distributed order. Such equations were introduced in A.

Fractal properties of anomalous diffusion in intermittent maps.

An intermittent nonlinear map generating subdiffusion is investigated. Computer simulations show that the generalized diffusion coefficient of this map has a fractal, discontinuous dependence on control parameters. An amended continuous time random-walk theory well approximates the coarse behavior of this quantity in terms of a continuous function.

Natural cutoff in Lévy flights caused by dissipative nonlinearity.

Lévy flight models are often used to describe stochastic processes in complex systems. However, due to the occurrence of diverging position and/or velocity fluctuations Lévy flights are physically problematic if describing the dynamics of a particle of finite mass. Here we show that the velocity distribution of a random walker subject to Lévy noise can be regularized by nonlinear friction, leading to a natural cutoff in the velocity distribution and finite velocity variance.

Bifurcation, bimodality, and finite variance in confined Lévy flights.

We investigate the statistical behavior of Lévy flights confined in a symmetric, quartic potential well U(x) proportional, variant x(4). At stationarity, the probability density function features a distinct bimodal shape and decays with power-law tails which are steep enough to give rise to a finite variance, in contrast to free Lévy flights. From a delta-initial condition, a bifurcation of the unimodal state is observed at t(c)>0.

[Cytomegalovirus infection in bone marrow transplantation].

Aim: To evaluate frequency and clinical features of CMV infection in patients with hematological malignancies (HM) after autologous and allogeneic stem cell transplantation, protective and therapeutic methods, efficiency of CMV hyperimmune immunoglobulin cytotest (Biotest Pharma).

Material And Methods: The trial enrolled 22 patients (group 1) with HM and severe aplastic anemia after allogeneic bone marrow transplantation, 58 patients (group 2) with HM after autologous stem cell transplantation. The patients were examined for CMV infection by serologic methods and PCR.

Local and global control of high-period unstable orbits in reversible maps.

We study the nonlinear dynamics of a complex system, described by a two-dimensional reversible map. The phase space of this map exhibits elements typical of Hamiltonian systems (stability islands) as well as of dissipative systems (attractor). Due to the interaction between the stability islands and the attractor, the transition to chaos in this system occurs through the collapse of the stability island and stochastization of the limiting-cycles orbits.

[The in-vitro effect of constant and pulsating magnetic field on immunocompetent blood cells of hematologic patients].

Immunologic characteristics were studied in 103 patients with multiple myeloma, acute leukemia, chronic lymphocytic leukemia and non-Hodgkin's disease following in vitro exposure of blood to a low-intensity static field (SF) and alternating field (AF) or pulsating magnetic field (PF). In a SF-AF study of multiple myeloma, a 30 min exposure had a positive effect on expression of tumor cells and T-cell markers and stimulated the regulatory function of T-lymphocytes. With SF-AF and PF application alternating, the expression of both +CD3 and +CD4 and the +CD3/+CD4 ratio increased suggesting the lowering of immunological deficiency.

[The effect in vitro of permanent and variable magnetic fields on immunocompetent blood cells from patients with hemoblastoses and non-Hodgkin's malignant lymphoma].

Immunologic parameters were studied in 54 patients with myeloma multiplex (MM), acute leukosis (AL), non-Hodgkin's disease (NHD) before and after in vitro exposure of these patients' blood to weak constant magnetic field (CMF) and CMF in combination with variable magnetic field (VMF). Blood irradiation with CMF over 60 min in AL and MM patients brought about in some cases enhancement of the expression of +CD3, +CD4 and CD8 together with augmentation of the immunoregulatory index. At the same time phagocytic activity of leucocytes got increased as did digesting capability and index of completeness of phagocytosis, i.

Inhibition of glutamate-induced intensification of free radical reactions by gangliosides: possible role in their protective effect in rat cerebellar granule cells and brain synaptosomes.

The neurotoxic effect of exposure of rat cerebellar granule cells to glutamate (100 microM) is to a large extent prevented by incubation of neurons not only with micromolar, but even with nanomolar concentrations of gangliosides GM1, GD1b, and GT1b. GM1 was also shown to decrease significantly the per cent of dead neurons in culture after induction of lipid peroxidation. Exposure to glutamate was found to cause a significant decrease of the activity of Na+, K+-ATP-ase in rat brain cortex synaptosomes, but superoxide dismutase, alpha-tocopherol, or 10-100 nM GM1 practically prevented its action.

[Effect of prednisolone, hyperbaric oxygenation and their combination on the glucose content of the blood and glycogen in the organs of white rats].

A single injection of prednisolone in doses of 10, 30, 80 and 100 mg/kg provoked different shifts in blood glucose concentration and glycogen content in the heart, liver, and skeletal muscles. Prednisolone increased liver glycogen content almost in all the doses. Administered in doses of 10 and 30 mg/kg the drug reduced blood glucose level and glycogen content in the myocardium and skeletal muscles.