Small is Powerful: Demonstration of the Impact of Nanoformed Piroxicam in a Controlled Clinical Study.

Purpose: New solutions are needed to enable the efficient use of poorly water-soluble drugs. Therefore, we aimed to demonstrate that decreasing particle size with a solution-to-particle method known as nanoforming can improve dissolution and thus bioavailability.

Methods: Piroxicam, a poorly water-soluble non-steroidal anti-inflammatory drug (NSAID), was used as a model compound.

New Insights into Nanoplastics Ecotoxicology: Effects of Long-Term Polystyrene Nanoparticles Exposure on .

Despite the growing concern over nanoplastics' (NPls) environmental impacts, their long-term effects on terrestrial organisms remain poorly understood. The main aim of this study was to assess how NPls exposure impacts both the parental (F1) and subsequent generations (F2 and F3) of the soil-dwelling species . After a standard exposure (28 days), we conducted a multigenerational study along three generations (84 days), applying polystyrene nanoparticles (PS NPs; diameter of 44 nm) as representatives of NPls.

Photoprotective bioactivity present in a unique marine bacteria collection from Portuguese deep sea hydrothermal vents.

Interesting biological activities have been found for numerous marine compounds. In fact, screening of phylogenetically diverse marine microorganisms from extreme environments revealed to be a rational approach for the discovery of novel molecules with relevant bioactivities for industries such as pharmaceutical and cosmeceutical. Nevertheless, marine sources deliverables are still far from the expectations and new extreme sources of microbes should be explored.

A powerful yeast-based screening assay for the identification of inhibitors of indoleamine 2,3-dioxygenase.

Activation of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1) underlies the course of several human pathological conditions and, to date, no efficacious therapeutic IDO inhibitors are available. We proposed to develop a robust screening system based on the use of yeast cells to identify new lead compounds for the pharmacological inhibition of IDO-the BLOCKADE platform. Yeast combines the advantages of a relevant surrogate model for eukaryotic cell processes with the amenity to miniaturization and automation.