Publications by authors named "Gonca Ozan Kocamuftuoglu"
Article Synopsis
- * Mice were divided into five groups, treated with varying doses of APAP, NAC, and CsA, and various analyses were conducted to assess liver damage, including serum enzyme levels and immune responses in liver tissue.
- * Results showed that APAP caused significant liver damage, evidenced by increased serum enzymes and histological changes, but the combination treatment of NAC and CsA effectively improved liver health indicators and reduced liver
Metabolic alterations and inflammation are regarded as hallmarks of cancer. Glycolytic flux and intermediate accumulation lead to the production of building blocks and NADPH which is important in protecting the cell from oxidative damage. Inflammation causes the release of mediators responsible for regulating molecular mechanism affecting metabolic pathways.
View Article and Find Full Text PDFEarly-stage diabetes can be defined as the stages before absolute insulin deficiency in patients. In this study, the early stage oxidative effect of streptozotocin(STZ) induced diabetes mellitus was evaluated. 28 male adult Sprague-Dawley rats were divided into four groups; control group and 7th, 14th, 21st days diabetic groups.
View Article and Find Full Text PDFTumor microenvironment, genetic, and non-genetic factors are responsible for the atypical metabolic feature of cancer cells. Aberrant activity of PI3K/Akt pathway, increased glycolytic flux, and decreased intracellular pH gradient are the leading causes of this feature. Calcium Fructoborate (CaFB), a sugar-borate ester, has major benefits for human health.
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